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Methanolic extract from the root of Bupleuri falcatum L. attenuates cocaine-induced c-Fos expression in rat brain.  

Choi, Seong-Hun (Dept. of Anatomy and Histology, College of Oriental Medicine, Daeggu Haany Univ.)
Ku, Sae-Kwang (Dept. of Anatomy and Histology, College of Oriental Medicine, Daeggu Haany Univ.)
Han, Chang-Hyun (TKM Information Research Division, Korea Institute of Oriental Medicine)
Yang, Chae-Ha (Dept. of Physiology, College of Oriental Medicine, Daegu Haany Univ.)
Publication Information
Korean Journal of Oriental Medicine / v.16, no.1, 2010 , pp. 141-147 More about this Journal
Abstract
Objectives : The aim of present study is to examine the effect of methanolic extract from the root of Bupleurum falcatum L. (BF) on acute cocaine-induced c-Fos expression in the rat caudate putamen (CPu), a major dopaminergic terminal. Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 mg/kg) or saline 30 min after an administration of either extract of BF (100 mg/kg, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy. Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu. Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.
Keywords
Bupleurum falcatum; Cocaine; C-Fos; The caudate putamen;
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1 Chen SM, Sato N, Yoshida M, Satoh N, and Ueda S. Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice. J Ethnopharmacol. 2008;116(3):397-402.   DOI   ScienceOn
2 Heidbreder CA, Schenk S, Partridge B, Shippenberg TS. Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective kappa-opioid receptor agonist. Synapse. 1998;30(3):255-62.   DOI   ScienceOn
3 Wu WS, Hsu HY. Involvement of p-15 and p-16 gene expression in saikosaponin a- and TPA-induced growth inhibition of hepG2 cells. Biochem. Biophys. Res. Commun. 2001;285:183-187.   DOI   ScienceOn
4 Leung CY, Liu L, Wong RN, Zeng YY, Li M, Zhou H. Saikosaponin-d inhibits T cell activation through the modulation of PKCtheta, JNK, and NF-kappaB transcription factor. Biochem Biophys Res Commun. 2005;338(4):1920-7.   DOI   ScienceOn
5 Liu Y, Wu H, Ge F. Chemical constituents analysis on anticonvulsive effect of three extracts from radix bupleuri. Zhong Yao Cai. 2002;25(9):635-7.
6 Drago J, Gerfen CR, Westphal H, Steiner H. D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum. Neuroscience. 1996;74(3):813-823.   DOI   ScienceOn
7 Chinese Pharmacopoeia Commission. Pharmacopoeiaof People's Republic of China vol. 1. Beijing:Chemical Industry Press. 2005:196.
8 Kimata H, Kasai R, Tanaka O. Saponins of Juk-Siho and Roots of Bupleurum longeradiatum TURCZ. Chemical & pharmaceutical bulletin. 1982:4373-7.
9 Takagi T, Shibata M. Pharmacological studies on Bupleurum falcatum L. II. Antiinflammatory and other pharmacological actions of crude saikosides. Yakugaku Zasshi. 1969;89:1367-78.
10 Abe H, Sakaguchi M, Odashima S, Arichi S. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1982;320(3):266-71.   DOI   ScienceOn
11 Chang HM, But PPH, eds. Pharmacology and applications of Chinese materia medica, Vol. 2. Singapore:WorldScientificPublishing. 1987.
12 Liao JF, Jan YM, Huang SY, Wang HH, Yu LL, Chen CF. Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. Proc Natl Sci Counc Repub China B. 1995;19(3):151-8.
13 Kuczenski R, Segal DS, Aizenstein ML. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics J Neurosci. 1991:2703-2712.
14 Torres G, Rivier C. Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study. Brain Res. 1994;647(1):1-9.   DOI   ScienceOn
15 Ann M. Graybiel, Rosario Moratalla, Harold A. Robertson Amphetamine and Cocaine Induce Drug-Specific Activation of the c-Fos Gene in Striosome- Matrix Compartments and Limbic Subdivisions of the Striatum. PNAS. 1990;6912-6916.
16 Koob GF, Nestler EJ. The neurobiology of drug addiction. J Neuropsychiatry Clin Neurosci. 1997;9:482-497.
17 Herrera DG, Robertson HA. Activation of c-fos in the brain. Prog Neurobiol. 1996;50:83-107.   DOI   ScienceOn
18 Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 6th edition. New York:Elsevier/Academic Press. 2009.
19 Young ST, Porrino LJ, Iadarola MJ. Cocaine induces striatal c-Fos-immunoreactive proteins via dopaminergic D1 receptors. PNAS. 1991;88:1291-1295.
20 Lee B, Yang CH, Hahm DH, Choe ES, Lee HJ, Pyun KH, Shim I. Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine-induced Sensitization. Evid Based Complement Alternat Med. 2009;6(1):85-90.   DOI   ScienceOn
21 Jang EY, Choe ES, Hwang M, Kim SC, Lee JR, Kim SG, Jeon JP, Buono RJ, Yang CH. Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. Eur J Pharmacol. 2008;587(1-3):124-8.   DOI   ScienceOn
22 Sun XB, Matsumoto T, Yamada H. Effects of a polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol. 1991;43(10):699-704.   DOI