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Differentiation of Parkinson's Disease and Essential Tremor on I-123 IPT(I-123-N-(3-iodopropen-2-yl)-$2{\beta}$-carbomethoxy- $3{\beta}$-(4-cholorophenyl) tropane) Brain SPECT  

Pai, Moon-Sun (Department of Nuclear Medicine, Kwandong University College of Medicine)
Choi, Tae-Hyun (Department of Nuclear medicine, Korea Institute of Radiological and Medical Science)
Ahn, Sung-Min (Department of Diagnostic Radiology, Gachon University of Medicine and Science)
Choi, Jai-Yong (Department of Nuclear Medicine, Yonsei University College of Medicine)
Ryu, Won-Gee (Department of Nuclear Medicine, Yonsei University College of Medicine)
Lee, Jae-Hoon (Department of Nuclear Medicine, Yonsei University College of Medicine)
Ryu, Young-Hoon (Department of Nuclear Medicine, Yonsei University College of Medicine)
Publication Information
Nuclear Medicine and Molecular Imaging / v.43, no.2, 2009 , pp. 100-106 More about this Journal
Abstract
Purpose: The study was to assess I-123-N-(3-iodopropen-2-yl)-2[beta]-carbomethoxy-3[beta]-(4-cholorophenyl) tropane(IPT) SPECT in differential diagnosis among early stage of Parkinson's disease(PD) and essential tremor(ET) and normal control(NL) groups quantitatively. Materials and Methods: I-123 IPT brain SPECT of 50 NL, 20 early PD, 30 advanced PD, and 20 ET were performed at 20 minutes and 2 hours. Specific/nonspecific binding of striatum was calculated by using right and left striatal specific to occipital non-specific uptake ratio(striatum-OCC/OCC). Results: Mean value of specific/nonspecific binding ratio was significantly different between advanced PD group and NL group. However, significant overlap of striatal specific/nonspecific binding ratio was observed between PD group and ET group. Bilateral striatal specific/nonspecific binding ratios were decreased in advanced PD. Lateralized differences in the striatal uptake of I-123 IPT correlated with asymmetry in clinical findings in PD group. Conclusion: I-123 IPT SPECT may be a useful method for the diagnosis of PD and objective evaluation of progress of clinical stages. Care should be made in the differential diagnosis of early stage of PD and other motor disturbances mimicking PD such as ET in view of significant overlap in striatal I-123 specific/nonspecific binding ratio.
Keywords
Dopamine transporter; I-123 IPT SPECT; essential tremor; Parkinson' disease;
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