Browse > Article

Ipsilateral Cerebral and Contralateral Cerebellar Hyperperfusion in Patients with Unilateral Cerebral Infarction; SPM Analysis  

Hong, Sun-Pyo (Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine)
Yoon, Joon-Kee (Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine)
Choi, Bong-Hoi (Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine)
Joo, In-Soo (Department of Neurology, Ajou University School of Medicine)
Yoon, Seok-Nam (Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine)
Publication Information
Nuclear Medicine and Molecular Imaging / v.42, no.5, 2008 , pp. 347-353 More about this Journal
Abstract
Purpose: Cortical reorganization has an important role in the recovery of stroke. We analyzed the compensatory cerebral and cerebellar perfusion change in patients with unilateral cerebral infarction using statistical parametric mapping (SPM). Materials and Methods: Fifty seven $^{99m}TC-Ethylene$ Cystein Diethylester (ECD) cerebral perfusion SPECT images of 57 patients (male/female=38/19, mean age=$56{\pm}17\;years$) with unilateral cerebral infarction were evaluated retrospectively. Patients were divided into subgroups according to the location (left, right) and the onset (acute, chronic) of infarction. Each subgroup was compared with normal controls (male/female=11/1, mean age=$36{\pm}10\;years$) in a voxel-by-voxel manner (two sample t-test, p<0.001) using SPM. Results: All 4 subgroups showed hyperperfusion in the ipsilateral cerebral cortex, but not in the contralateral cerebral cortex. Chronic left and right infarction groups revealed hyperperfusion in the ipsilateral primary sensorimotor cortex, meanwhile, acute subgroups did not. Contralateral cerebellar hyperperfusion was also demonstrated in the chronic left infarction group. Conclusion: Using $^{99m}Tc-ECD$ SPECT, we observed ipsilateral cerebral and contralateral cerebeller hyperperfusion in patients with cerebral infarction. However, whether these findings are related to the recovery of cerebral functions should be further evaluated.
Keywords
$^{99m}Tc-ECD$ perfusion SPECT; cerebral infarction; statistical parametric mapping; functional recovery;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Witte OW. Lesion induced plasticity as a potential mechanism for recovery and rehabilitative training. Curr Opin Neurol 1998; 11:655-62   DOI   ScienceOn
2 Lee RG, van Donkelaar P. Mechanism underlying functional recovery following stroke. Can J Neurol Sci 1995;22:257-63   DOI
3 Jodzio K, Drumm DA, Nyka WM, Lass P, Gasecki D. The contribution of the left and right hemispheres to early recovery from aphasia: a SPECT prospective study. Neuropsychol Rehabil 2005;15:588-604   DOI   ScienceOn
4 Small SL, Hlustik P, Noll DC, Genovese C, Solodkin A. Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain 2002;125: 1544-7   DOI   ScienceOn
5 Sparks R, Helm N, Albert M. Aphasia rehabilitation resulting from melodic intonation therapy. Cortex 1974;10:303-16   DOI
6 Yan T, Hui-Chan CW, Li LS. Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke: a randomized placebo-controlled trial. Stroke 2005;36:80-5   DOI   ScienceOn
7 Nelles G, Jentzen W, Jeuptner M, Muller S, Diener HC. Arm training induced brain plasticity in stroke studies with serial positron emission tomography. Neuroimage 2001;13:1146-54
8 Li Y, Jiang N, Powers C, Chopp M. Neuronal damage and plasticity identified by microtubule-associated protein 2, growthassociated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats. Stroke 1998;29:1972-80   DOI   ScienceOn
9 Nelles G, Spiekramann G, Jueptner M, Leonhardt G, Muller S, Gerhard H, et al. Evolution of functional reorganization in hemiplegic stroke: a serial positron emission tomographic activation study. Ann Neurol 1999;46:901-09   DOI   ScienceOn
10 Palmer E, Ashby P, Hajek VE. Ipsilateral fast corticospinal pathways do not account for recovery in stroke. Ann Neurol 1992;32:519-25   DOI   ScienceOn
11 Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Stroke. Neurologic and functional recovery the Copenhagen Stroke Study. Phys Med Rehabil Clin N Am 1999;10:887-906   DOI
12 Jorgensen HS, Reith J, Nakayama H, Kammersgaard LP, Raaschou HO, Olsen TS. What determines good recovery in patients with the most severe strokes? The Copenhagen Stroke Study. Stroke 1999;30:2008-12   DOI   ScienceOn
13 Baron JC, Bousser MG, Cornar D, Castaigne P. 'Crossed cerebellar diaschisis' in human supratentorial brain infarction. Trans Am Neurol Assoc 1980;105:459-61
14 Chollet F, DiPiero V, Wise RJ, Brooks DJ, Dolan RJ, Frackowiak RS. The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography. Ann Neurol 1991;29:63-71   DOI   ScienceOn
15 Feydy A, Carlier R, Roby-Brami A, Bussel B, Cazalis F, Pierot L, Burnod Y, Maier MA. Longitudinal study of motor recovery after stroke: recruitment and focusing of brain activation. Stroke 2002;33:1610-7   DOI   ScienceOn
16 Cao Y, Vikingstad EM, Huttenlocher PR, Towle VL, Levin DN. Functional magnetic resonance studies of the reorganization of the human hand sensorimotor area after unilateral brain injury in the perinatal period. Proc Natl Acad Sci USA 1994;91:9612-6   DOI
17 Cramer SC, Bastings EP. Mapping clinically relevant plasticity after stroke. Neuropharmacology 2000;39:842-51   DOI   ScienceOn
18 Choi JW, Park JH, Yu SJ. Plasma Neuron-specific enolase and glutamic acid level in acute ischemic stroke. J Korean Soc Emerg Med 2006;17:254-8
19 Feeney DM, Gonzalez A, Law WA. Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 1982;217:855-7   DOI
20 Pantano P, Formisano R, Ricci M, Di Piero V, Sabatini U, Di Pofi B, Rossi R, et al. Motor recovery after stroke. Morphological and functional brain alteration. Brain 1996;119:1849-57   DOI   ScienceOn
21 Kelly HM, Wolf PA, Kase CS, Gresham GE, Kannel WB, D'Agostino RB. Time course of functional recovery after stroke : the Framingham study. J Neurol Rehabil 1989;3:65-70
22 Middleton FA, Strik PL: Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 1994;266:458-61   DOI
23 Chu WJ, San Pedro EC, Hetherington HP, Liu HG, Mountz JM. Post-stroke cerebral reorganization in human identified by 31P MR Spectroscopic imaging and F-18 FDG PET. Proc Int Soc Magn Reson Med 2002;10:1030
24 Hendricks HT, van Limbeek J, Geurts AC, Zwarts MJ. Motor recovery after stroke: a systematic review of the literature. Arch Phys Med Rehabil 2002;83:1629-37   DOI   ScienceOn
25 Mohr JP, Foulkes MA, Polis AT, Hier DB, Kase CS, Price TR, et al. Infarct topography and hemiparesis profiles with cerebral onvexity infarction: the stroke data bank. J Neurol Neurosurg Psychiatry 1993;56:344-51   DOI
26 Schaechter JD, Kraft E, Hillard TS, Dijkhuizen RM, Benner T, Finklestein SP, et al. Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study. Neurorehabil Neural Repair 2002;16:326-38   DOI
27 Taub E, Miller NE, Novack TA, Cook EW 3rd, Fleming WC, Nepomuceno CS, et al. Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 1993;74:347-54