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Quality Control of Residual Solvents in $[^{18}F]$FDG Preparations by Gas Chromatography  

Lee, Hak-Jeong (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Jeong, Jae-Min (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Lee, Yun-Sang (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Kim, Hyung-Woo (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Chang, Young-Soo (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Lee, Dong-Soo (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Chung, June-Key (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Lee, Myung-Chul (Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University)
Publication Information
Nuclear Medicine and Molecular Imaging / v.41, no.6, 2007 , pp. 566-569 More about this Journal
Abstract
Purpose: Analysis of volatile organic solvents in 2-deoxy-2-$[^{18}F]$ fluoro-D-glucose ($[^{18}F]$FDG) preparations was performed by gas chromatography (GC), in accordance with USP. Materials and Methods: Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID. Results: We determined the amounts of ethanol and acetonitrile on every batch of our routine $[^{18}F]$FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of $[^{18}F]$FDG, the amount of acetonitrile and ethanol in the final product were well below the maximum allowable limit described in the USP. Conclusion: Our $[^{18}F]$FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds.
Keywords
residual solvents$[^{18}F]$; FDG; gas chromatography; quality control;
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