Browse > Article

Nuclear Imaging in Epilepsy  

Chun, Kyung-Ah (Department of Nuclear Medicine, Yeungnam University Hospital)
Publication Information
Nuclear Medicine and Molecular Imaging / v.41, no.2, 2007 , pp. 97-101 More about this Journal
Abstract
Correct localization of epileptogenic zone is important for the successful epilepsy surgery. Both ictal perfusion single photon emission computed tomography (SPECT) and interictal F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) can provide useful information in the presurgical localization of intractable partial epilepsy. These imaging modalities have excellent diagnostic sensitivity in medial temporal lobe epilepsy and provide good presurgical information in neocortical epilepsy. Also provide functional information about cellular functions to better understand the neurobiology of epilepsy and to better define the ictal onset zone, symptomatogenic zone, propagation pathways, functional deficit zone and surround inhibition zones. Multimodality imaging and developments in analysis methods of ictal perfusion SPECT and new PET ligand other than FDG help to better define the localization.
Keywords
Epilepsy; SPECT; PET;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Lee DS, Lee SK. Functional Neuroimaging in Epilepsy: FDG-PET and SPECT
2 Ollenberger GP, Byrne AJ, Berlangieri SU, Rowe CC, Pathmaraj K, Reutens DC, et al. Assessment of the role of FDG PET in the diagnosis and management of children with refractory epilepsy. Eur J Nucl Med Mol Imaging 2005; 32:1311-6   DOI   ScienceOn
3 Zubal IG, Spanaki MV, MacMullan J, Corsi M, Seibyl JP, Spncer SS. Influence of technetium-99m-hexamethylpropylene amine oxime injection time on single-photon emission tomography perfusion changes in epilepsy. Eur J Nucl Med 1999;26:12-7   DOI
4 Lee SK, Lee S-H, Kim S-K, Lee DS, Kim H. The clinical usefulness of ictal SPECT in temporal lobe epilepsy: the lateralization of seizure focus and correlation with EEG. Epilepsia 2000;41:955-62   DOI   ScienceOn
5 Park SA, Lee DS, Lee SG, Kim SK, Jang MJ, Sohn MH, et al. Crossed Cerebellar Hyperperfusion on Ictal Tc-99m HMPAO Brain SPECT: Clinical Significance for Differentiation of Mesial or Lateral Temporal Lobe Epilepsy and Related Factors for Development. Korean J Nucl Med 2000;34:312-21   과학기술학회마을
6 Van Borgaert P, Massager N, Tugendharft P, Wikler D, Damhaut P, Levivier M, et al. Statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy. Neuroimage 2000;12:129-38   DOI   ScienceOn
7 Lee BI, Lee JD, Kim JY, Ryu YH, Kim WJ, Lee JH, et al. Single photon emission tomography-EEG relations in temporal lobe epilepsy. Neurology 1997;49:981-91   DOI   ScienceOn
8 Lee SK, Lee SY, Yun CH, Lee HY, Lee JS, Lee DS. Ictal SPECT in neocortical epilepsies: clinical usefulness and factors affecting the pattern of hyperperfusion. Neuroradiology 2006;48:678-84   DOI
9 Kagawa K, Chugani DC, Asano E, Juhasz C, Muzik O, Shah A, et al. Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol 2005;20:429-38   DOI
10 Lee SK, Lee SY, Kim KK, Hong KS, Lee DS, Chung CK. Surgical outcome and prognostic factors of cryptogenic neocortical epilepsy. Ann Neurol 2005;58:525-32   DOI   ScienceOn
11 McDonald CR, Swartz BE, Halgren E, Patell A, Daimes R, Mandelkern M. The relationship of regional frontal hypometabolism to executive function: a resting fluorodeoxyglucose PET study of patients with epilepsy and healthy controls. Epilepsy Behav 2006;9:58-67   DOI   ScienceOn
12 Kim S-K, Lee DS, Lee SK, Kim YK, Kang KW, Chung CK, et al. Diagnostic performance of 18-F-FDG-PET and ictal 99m-Tc- HMPAO SPECT in occipital lobe epilepsy. Epolepsia 2001;42: 1531-40   DOI   ScienceOn
13 Lee DS, Lee JS, Kang KW, Jang MJ, Lee SK, Chung J-K, et al. Disparity of perfusion and glucose metabolism of epileptogenic zones in temporal lobe epilepsy demonstrated by SPM/SPAM analysis on 15-O water PET, 18-F-FDG-PET, and 99mTc-HMPAO SPECT. Epilepsia 2001;42:1515-22   DOI   ScienceOn
14 Lee DS, Lee SK, Kim SK, Kang KW, Kang E, Lee KH, et al. Late postictal residual perfusion abnormality in epileptogenic zone found on 6-hour postictal SPECT. Neurology 2000;55:835-41   DOI   ScienceOn
15 Rosenow F, Lüders H. Presurgical evaluation of epilepsy. Brain 2001;124:1683-700   DOI   ScienceOn
16 Hammers A, Koepp MJ, Brooks DJ, Duncan JS. Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis. Epilepsia 2005;46:944-48   DOI   ScienceOn
17 Tsuru N, Kawasaki H, Genda S, Hara K, Hashiguchi H, Ueda Y. Effect of unilateral dentate nucleus lesions on amygdaloid kindling in rats. Epilepsia 1992;33:213-21   DOI   ScienceOn
18 Won JH, Lee JD, Chung TS, Kim HS, Park CY. Increased contralateral cerebellar uptake of 99mTc-HMPAO on ictal brain SPECT. Korean J Nucl Med 1995;29:9-14   과학기술학회마을
19 Fedi M, Berkovic SF, Marini C, Mulligan R, Tochon-Danguy H, Reutens DC. A GABAA receptor mutation causing generalized epilepsy reduces benzodiazepine receptor binding. Neuroimage 2006;32:995-1000   DOI   ScienceOn
20 Cherry SR. Multimodality in vivo imaging systems: twice the power or double the trouble? Annu Rev Biomed Eng 2006;8:35-62   DOI   ScienceOn
21 Picard F, Bruel D, Servent D, Saba W, Fruchart-Gaillard C, Schollhorn-Peyronneau MA, et al. Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study. Brain 2006;129:2047-60   DOI   ScienceOn
22 Paesschen WV, Dupont P, Sunaert S, Goffin K, Laere KV. The use of SPECT and PET in routine clinical practice in epilepsy. Current Opinion in Neurology 2007;20:194-202   DOI   ScienceOn
23 Wetjen NM, Cascino GD, Fessler AJ, So EL, Buchhalter JR, Mullan BP, et al. Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg 2006;105:71-6   DOI   ScienceOn
24 Rosenberg DS, Demarquay G, Jouvet A, Le Bars D, Streichenberger N, Sindou M, et al. [11C]-Methionine PET: dysembryoplastic neuroepithelial tumours compared with other epileptogenic brain neoplasms. J Neurol Neurosurg Psychiatry 2005;76:1686-92   DOI   ScienceOn
25 Nelissen N, Van Paesschen W, Baete K, Van Laere K, Palmini A, Van Billioen H, et al. Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. Neuroimage 2006; 32:684-95   DOI   ScienceOn
26 Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, et al. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative 18-F FDG PET: a clinical validation of statistical parametric mapping. Neuroimage 1999;9:63-80   DOI   ScienceOn
27 Lee DS, Lee SK, Kim YK, Kang E, Lee JS, Chung J-K. The usefulness of repeated ictal SPECT for the localization of epileptogenic zones in intractable epilepsy. Eur J Nucl Med 2002;29:607-14   DOI   ScienceOn
28 Kim YK, Lee DS, Lee SK, Chung CK, Chung J-K, Lee MC. 18F-FDG-PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med 2002;43:1167-74