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Imaging of Dopaminergic System in Movement Disorders  

Kim, Yu-Kyeong (Department of Nuclear Medicine, Seoul National University College of Medicine)
Kim, Sang-Eun (Department of Nuclear Medicine, Seoul National University College of Medicine)
Publication Information
Nuclear Medicine and Molecular Imaging / v.41, no.2, 2007 , pp. 132-140 More about this Journal
Abstract
Parkinson's disease is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several radiopharmaceutics have been developed to evaluate the integrity of dopaminergic neuronal system. In vivo PET and SPECT imaging of presynaptic dopamine imaing are already applied to Parkinson's disease and other parkinsonism, and can demonstrate the dopaminergic dysfunction. This review summarized the use of the presynaptic dopaminergic imaging in PD as biomarkers in evaluation of disease progression as well as in diagnosis of PD.
Keywords
Parkinson's disease; dopaminergic system; biomarker;
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