Browse > Article

Effects of Attenuation and Scatter Corrections in Cat Brain PET Images Using microPET R4 Scanner  

Kim, Jin-Su (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Jae-Sung (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Jong-Jin (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Byeong-Il (Department of Nuclear Medicine, Seoul National University College of Medicine)
Park, Min-Hyun (Department of Otolaryngology Head and Neck Surgery, Seoul National University College of Medicine)
Lee, Hyo-Jeong (Department of Otolaryngology Head and Neck Surgery, Seoul National University College of Medicine)
Oh, Seung-Ha (Department of Otolaryngology Head and Neck Surgery, Seoul National University College of Medicine)
Kim, Kyeong-Min (Research Institute of Nuclear Medicine, Korea Institute of Radiology & Medical Sciences)
Cheon, Gi-Jeong (Department of Nuclear Medicine, Korea Institute of Radiology & Medical Sciences)
Lim, Sang-Moo (Department of Nuclear Medicine, Korea Institute of Radiology & Medical Sciences)
Chung, June-Key (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Myung-Chul (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine)
Publication Information
Nuclear Medicine and Molecular Imaging / v.40, no.1, 2006 , pp. 40-47 More about this Journal
Abstract
Purpose: The aim of this study was to examine the effects of attenuation correction (AC) and scatter correction (SC) on the quantification of PET count rates. Materials and Methods: To assess the effects of AC and SC $^{18}F$-FDG PET images of phantom and cat brain were acquired using microPET R4 scanner. Thirty-minute transmission images using $^{68}Ge$ source and emission images after injection of FDG were acquired. PET images were reconstructed using 2D OSEM. AC and SC were applied. Regional count rates were measured using ROIs drawn on cerebral cortex including frontal, parietal, and latral temporal lobes and deep gray matter including head of caudate nucleus, putamen and thalamus for pre- and post-AC and SC images. The count rates were then normalized with the injected dose per body weight. To assess the effects of AC, count ratio of "deep gray matter/cerebral cortex" was calculated. To assess the effects of SC, ROIs were also drawn on the gray matter (GM) and white matter (WM), and contrast between them ((GM-WM)/GM was measured. Results: After the AC, count ratio of "deep gray matter/cerebral cortex" was increased by $17{\pm}7%$. After the SC, contrast was also increased by $12{\pm}3%$. Conclusion: Relative count of deep gray matter and contrast between gray and white matters were increased after AC and SC, suggesting that the AC would be critical for the quantitative analysis of cat brain PET data.
Keywords
Attenuation correction; Scatter correction; animal PET;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Cherry SR, Shao Y, Silverman RW, Meadors K, Siegel S, Chatziioannou A, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci 1997;44: 1161-6   DOI   ScienceOn
2 Tai C, Chatziioannou A, Siegel S, Young J, Newport D, Goble RN, et al. Performance evaluation of the microPET P4: a PET system dedicated to animal imaging. Phys Med Biol 2001;46: 1845-62   DOI   ScienceOn
3 Goertzen AL, Jones DW, Seidel J, Li K, Green MV. First results from the high-resolution mouseSPECT annular scintillation camera. IEEE Trans Med Imaging 2005;24: 863-7   DOI   ScienceOn
4 Cherry SR, Sorenson JA, Phelps ME. Physics in nuclear medicine. 3rd ed.: Elsevier Science (U.S.A.); 2003. p. 366-7
5 Concorde Microsystems Inc. microPET $Manager^{TM}$ user guide. Rev. 2. 2002
6 Watson CC. New, faster image-based scatter correction for 3D PET. IEEE Trans Nucl Sci 2000;47:1587-94   DOI   ScienceOn
7 Meikle SR, Bailey DL, Hooper PK, Eberl S, Hutton BF, Jones WF, et al. Simultaneous Emission and Transmission Measurements for Attenuation Correction in Whole-body PET. J Nucl Med 1995;36:1680-8
8 Matsumura A, Mizokawa S, Tanaka M, Wada Y, Nozaki S, Nakamura F, et al. Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: comparison between quantitative data obtained with microPET and ex vivo autoradiography. NeuroImage 2003;20:2040-50   DOI   ScienceOn
9 Knoess C, Siegel S, Smith A, Newport D, Richerzhagen N, Winkeler A, et al. Performance evaluation of the microPET R4 PET scanner for rodents. Eur J Nucl Med Mol Imaging 2003;30: 737-47   DOI
10 Metzler SD, Jaszczak RJ, Patil NH, Vemulapalli S, Akabani G, Chin BB. Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation. IEEE Trans Med Imaging 2005;24:853-62   DOI   ScienceOn
11 Cao Z, Bal G, Accorsi R, Acton PD. Optimal number of pinholes in multi-pinhole SPECT for mouse brain imaging-a simulation study. Phys Med Biol 2005;50:4609-24   DOI   ScienceOn
12 Turkington TG, Coleman RD. An Evaluation of Post- Injection Transmission Measurement in PET. IEEE Trans Nucl Sci 1994;41:1538-44   DOI   ScienceOn
13 Erdi YE, Nehmeh SA, Mulnix T, Humm JL, Watson CC. PET performance measurements for an LSO-based combined PET/CT scanner using the National Electrical Manufacturers Association NU 2-2001 standard. J Nucl Med 2004;45:813-21
14 Defrise M, Kinahan PE, Townsend DW, Michel C, Sibomana M, Newport DF. Exact and approximate rebinning algorithms for 3-D PET data. IEEE Trans Med Imaging 1997;16:145-58   DOI   ScienceOn
15 Concorde Microsystems Inc. $ASIpro^{TM}$ Version 4.0, Acquistion, Sinogram and Image Processing. 2002
16 Constantinesco A, Choquet P, Monassier L, Israel-Jost V, Mertz L. Assessment of left ventricular perfusion, volumes, and motion in mice using pinhole gated SPECT. J Nucl Med 2005;46:1005-11
17 Kim JS, Lee JS, Lee DS, Lee JJ, Lee HJ, Park MH, et al. Measurement of Glucose Metabolism of Auditory Cortex of Deaf Cat Using Animal PET. Korean J Nucl Med 2004;38:437 [abstract]
18 Watson CC, Casey ME, Eriksson L, Mulnix T, Adams D, Bendriem B. NEMA NU 2 performance tests for scanners with intrinsic radioactivity. J Nucl Med 2004;45:822-6
19 Missimer J, Maldi Z, Honer M, Keller C, Schubiger A, Ametamey S-M. Performance evaluation of the 16-module quad-HIDAC small animal PET camera. Phys Med Biol 2004;49: 2069-81   DOI   ScienceOn
20 Chow PL, Rannou FR, Chatziioannou AF. Attenuation correction for small animal PET tomographs. Phys Med Biol 2005;50: 1837-50   DOI   ScienceOn
21 Chow PL, Bai B, Siegel S, Leahy RM, Chatziioannou AF. Transmission imaging and attenuation correction for the microPET P4 tomograph. IEEE NSS/MIC 2003;1298-1302 [proceedings]
22 Pomper MG, Lee JS. Small Animal Imaging in Drug Development. Curr Pharm Des 2005;11:3247-72   DOI   ScienceOn
23 Andringa G, Drukarch B, Bol JG, de Bruin K, Sorman K, Habraken JB, et al. Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease. NeuroImage 2005;26:1150-8   DOI   ScienceOn