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Determination of Appropriate Sampling Frequency and Time of Multiple Blood Sampling Dual Exponential Method with $^{99m}Tc$-DTPA for Calculating GFR  

Kim, Chung-Ho (Departments of Radiology, College of Medicine, Catholic University of Korea)
O, Joo-Hyun (Departments of Radiology, College of Medicine, Catholic University of Korea)
Chung, Yong-An (Departments of Radiology, College of Medicine, Catholic University of Korea)
Yoo, Ie-Ryung (Departments of Radiology, College of Medicine, Catholic University of Korea)
Sohn, Hyung-Sun (Departments of Radiology, College of Medicine, Catholic University of Korea)
Kim, Sung-Hoon (Departments of Radiology, College of Medicine, Catholic University of Korea)
Chung, Soo-Kyo (Departments of Radiology, College of Medicine, Catholic University of Korea)
Lee, Hyoung-Koo (Departments of Biomedial Engineering, College of Medicine, Catholic University of Korea)
Publication Information
Nuclear Medicine and Molecular Imaging / v.40, no.1, 2006 , pp. 33-39 More about this Journal
Abstract
Purpose: To determine appropriate sampling frequency and time of multiple blood sampling dual exponential method with $^{99m}Tc$-DTPA for calculating glomerular filtration rate (GFR). Materials & Methods: Thirty four patients were included in this study. Three mCi of $^{99m}Tc$-DTPA was intravenously injected and blood sampling at 9 different times, 5ml each, were done. Using the radioactivity of serum, measured by gamma counter, the GFR was calculated using dual exponential method and corrected with the body surface area. Using spontaneously chosen 2 data points of serum radioactivity, 15 collections of 2-sample GFR were calculated. And 10 collections of 3-sample GFR and 12 collections of 4-sample GFR were also calculated. Using the 9-sample GFR as a reference value, degree of agreement was analyzed with Kendall's $\tau$ correlation coefficients, mean difference and standard deviation. Results: Although some of the 2-sample GFR showed high correlation coefficient, over or underestimation had evolved as the renal function change. The 10-120-240 min 3-sample GFR showed a high correlation coefficient (${\tau}=0.93$), minimal difference ($Mean{\pm}SD=-1.784{\pm}3.972$), and no over or underestimation as the renal function changed. The 4-sample GFR showed no better accuracy than the 3-sample GFR. Conclusions: In the wide spectrum of renal function, the 10-120-240 min 3-sample GFC could be the best choice for estimating the patients' renal function.
Keywords
$^{99m}Tc$-DTPA; Glomerular filtration rate; Multiple blood sampling technique; Two-compartment model;
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1 Sapirstein LA, Vidt DG, Mandel MJ, Hanusek G. Volumes of distribution and clearances of intravenously injected creatine in the dog [retracted in Bubeck BR. Quantitative evaluation of clearance. In: Ell PJ, Gambhir SS. Nuclear medicine in clinical diagnosis and treatment. 3rd ed. Edinburgh: Churchil Livingstone: 2004. p1538]. Am J Physiol 1955;181:330-6
2 Haycock GB, Schwarz GJ. Geometric method for measuring body surface area. A height-weight fomula validated in infants. J paediat 1978;93:62-6   DOI
3 Sigman EM, Elwood CM, Readan ME, Morris AM, Catanzaro A. The renal clearance of I-131 labelled sodium iothalamate in man. Invest Urol 1965;2:432-8
4 Gates GF. Glomerular filtration rate: estimation from fractional renal accumulation of $^{99m}Tc$-DTPA (stannous). AJR 1982;565-70
5 Russell CD, Bischoff PG, Rowell KL, Kontzen F, Lloyd LK, Tauxe WN, et al. Quality control of Tc-99m DPTA for measurement of glomerular filtration: concise communication. J Nucl Med. 1983;24:722-7
6 Mulligan JS, Blue PW, Hasbargen JA. Methods for measuring GFR with technetium-99m-DTPA: An analysis of several common methods. J Nucl Med 1990;31:1211-9
7 Cohen ML, Smith FG, Mindell RS, Vernier RL. A simple reliable method of measuring glomerular filtration rate using single low dose sodium iothalamate $^{131}I$. Pediatrics 1969;43:407-15
8 Bubeck BR. Quantitative evaluation of clearance. In: Ell PJ, Gambhir SS. Nuclear medicine in clinical diagnosis and treatment. 3rd ed. Edinburgh: Churchil Livingstone: 2004. p1537-45
9 Jackson J, Blue PW, Ghaed N. Glomerular filtration rate determined in conjunction with routine renal scanning. Radiology 1985;154: 203-5   DOI
10 Russell CD, Bischoff PG, Rowell KL, Kontzen F, Rowell KL, Keith YL et al. Measurement of glomerular filtration rate: single injection plasma clearance method without urine collection. J Nucl Med. 1985;26:1243-7
11 Fleming JH, Zivanovic MA, Blake GM, Burnston M, Cosgriff PS. Guideline for the measurement of glomerular filtration rate using plasma sampling. Nucl Med Commun 2004; 25:759-69   DOI   ScienceOn
12 Balachandran S, Toguri AG, Petresick TU, Abbott LC. Comparative evaluation of quantitative glomerular filtration rate measured by isotopic and non-isotopic methods. Clin Nucl Med 1981;4:150-3
13 Brochner-Mortensen J. Current status and measurement of glomerular filtration rate. Clin Physiol 1985;5:1-17   DOI   ScienceOn
14 Dubovsky EV, Russell CD. Quantitation of renal function with glomerular and tubular agents. Semin Nucl Med 1982;12:308-29   DOI   ScienceOn
15 Price M. Comparison of creatinine clearance to inulin clearance in the determination of glomerular filtration rate. J Urol 1972;107: 339-40   DOI
16 Jones J, Burnett PC. Creatinine metabolism in humans with decreased renal function: creatinine deficit. Clin Chem 1974;20: 1204-12