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Preparation and Animal Imaging of $^{153}Sm$-EDTMP as a Bone Seeking Radiopharmaceutical  

Choi, Tae-Hyun (Laboratory of Nuclear Medicine, Korean Institute of Radiological & Medical Science)
Kim, Se-Jung (Hanaro Application Research, Korea Atomic Energy Research Institute)
Shin, Byung-Chul (Hanaro Application Research, Korea Atomic Energy Research Institute)
Woo, Kwang-Sun (Laboratory of Nuclear Medicine, Korean Institute of Radiological & Medical Science)
Chung, Wee-Sup (Laboratory of Nuclear Medicine, Korean Institute of Radiological & Medical Science)
Choi, Chang-Woon (Laboratory of Nuclear Medicine, Korean Institute of Radiological & Medical Science)
Lim, Sang-Moo (Laboratory of Nuclear Medicine, Korean Institute of Radiological & Medical Science)
Publication Information
The Korean Journal of Nuclear Medicine / v.39, no.1, 2005 , pp. 44-48 More about this Journal
Abstract
Purpose: Ethylenediamine-tetramethylenephosphonic acid (EDTMP) has widely used chelator for the labeling of bone seeking radiopharmaceuticals complexed with radiometals. $^{153}Sm$ can be produced by the HANARO reactor at the Korea Atomic Energy Research Institute, Taejon, Korea. $^{153}Sm$ has favourable radiation characteristics $T1/2=46.7\;h,\;{\beta}_{max}=0.81\;MeV\;(20%),\;0.71\;MeV\;(49%),\;0.64\;MeV\;(30%)\;and\;{\gamma}=103\;keV\;(30%)$ emission which is suitable for imaging purposes during therapy. We investigated the labeling condition of $^{153}Sm$-EDTMP and imaging of $^{153}Sm$-EDTMP in normal rats. Materials and methods: EDTMP 20 mg was solved in 0.1 mL 2 M NaOH. $^{153}SmCl^3$ was added to EDTMP solution and pH of the reaction mixtures was adjusted to 3 and 12, respectively. Radiochemical purity was determined with paper chromatography. After 30 min. reaction, reaction mixtures were neutralized to pH 7.4, and the stability was estimated upto 120 hrs. Imaging studies of each reaction were perfomed in normal rats (37 MBq/0.1 mL). Results: The labeling yield of $^{153}Sm$-EDTMP was 99%. The stability of pH 8 reaction at 60, 96 and 120 hr was 99%, 95%, 89% and that of pH 12 at 36, 60, 96 and 120 hr was 99%, 95%, 88%, 66%, respectively. The $^{153}Sm$-EDTMP showed constantly higher bone uptake from 2 to 48 hr after injection. Conclusion: $^{153}Sm$-EDTMP, labeled at pH 8 reaction condition, has been stably maintained. Image of $^{153}Sm$-EDTMP at 2, 24, 48 hr after injection, demonstrate that $^{153}Sm$-EDTMP is a good bone seeking radiopharmaceuticals.
Keywords
$^{153}Sm$; EDTMP; radiopharmaceuticals;
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