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Comparison of the Diagnostic Performance of $^{14}C$-urea Breath Test According to Counting Method for the Diagnosis of Helicobacter pylori Infection  

Kim, Min-Woo (Department of Nuclear Medicine, Chonbuk National University Medical School)
Lim, Seok-Tae (Department of Nuclear Medicine, Chonbuk National University Medical School)
Lee, Seung-Ok (Department of internal Medicine, Chonbuk National University Medical School)
Sohn, Myung-Hee (Department of Nuclear Medicine, Chonbuk National University Medical School)
Publication Information
The Korean Journal of Nuclear Medicine / v.39, no.1, 2005 , pp. 21-25 More about this Journal
Abstract
Purpose: $^{14}C$-urea breath test (UBT) is a non-invasive and reliable method for the diagnosis of Helicobacter pylori (HP) infection. In this study, we evaluated the diagnostic performance of a new and rapid $^{14}C$-UBT (Heliprobe method), which was equipped with $Geiger-M\ddot{u}ller$ counter and compared the results with those obtained by using the conventional method. Materials and Methods: Forty-nine patients with dyspepsia underwent gastroduodenoscopy and $^{14}C$-UBT. A 37 KBq $^{14}C$-urea capsule was administered to patients and breath samples were collected. In Heliprobe method, patients exhaled into a Hellprobe BreathCard for 10 min. And then the activities of the BreathCard were countered using Heliprobe analyzer. In the conventional method, results were countered using liquid scintillation counter. During gastroduodenoscopy, 18 of 49 patients were underwent biopsies. According to these histologic results, we evaluated the diagnostic performance of two different methods and compared them. Also we evaluated the concordant and disconcordant rates between them. Results: In all 49 patients, concordant rate of both conventional and Heliprobe methods was 98% (48/49) and the discordant rate was 2% (1/49). Thirteen of 18 patients to whom biopsies were applied, were found to be HP positive on histologic results. And both Heliprobe method and conventional method classified 13 of 13 HP-positive patients and 5 of 5 HP-negative patients correctly (sensitivity 100%, specificity 100%, accuracy 100%). Conclusion: The Heliprobe method demonstrated the same diagnostic performance compared with the conventional method and was a simpler and more rapid technique.
Keywords
Helicobacter pylori; $^{14}C$ urea breath test; Peptic ulcer disease;
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1 Kao CH, Huang CK, Wang SJ, Hsu CY, Lin WY, Chen GH. Accuracy of a rapid 10-minute carbon-14 urea breath test for the diagnosis of Helicobacter pylori-associated peptic ulcer disease. Eur J Nucl Med 1993;20:708-11   PUBMED
2 MacOni G, Vago L, Galletta G, Imbesi V, Sangaletti O, Parente F, et al. Is routine histological evaluation an accurate test for Helicobacter pylori inection? Aliment Pharmacol Ther 1999;13: 327-31   DOI   ScienceOn
3 Weijnen CF, de Wit NJ, Numan ME, Kuipers EJ, Hoes AW, Verheij TJ. Helicobacter pylori testing in the primary care setting: which diagnostic test should be used? Aliment Pharmacol Ther 2001;15:1205-10   DOI   ScienceOn
4 Ozturk E, Yesilova Z, Ilgan S, Arslan N, Erdil A, Celasun B, et al. A new, practical, low-dose 14C-urea breath test for the diagnosis of Helicobacter pylori infection: clinical validation and comparison with the standard method. Eur J Nucl Med Mol Imaging 2003;30:1457-62   DOI   PUBMED
5 Gomollon F, Ducons JA, Santolaria S, Lera Omiste I, Guirao R, Ferrero M, et al. Breath test is very reliable for diagnosis of Helicobacter pylori infection in real clinical practice. Dig Liver Dis 2003;35:612-8   DOI   ScienceOn
6 Cutler AF, Havstad S, Ma CK, Blaser MJ, Perez-Perez GI, Schubert TT. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 1995;109:136-41   DOI   ScienceOn
7 Reilly TG, Poxon V, Sanders DSA, Elliott TSJ, Walt RP. Comparison of serum, salivary and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests. Gut 1997;40:454-8   DOI   PUBMED
8 Hegedus O, Ryden J, Rehnberg AS, Nilsson S, Hellstrom PM. Validated accuracy of a novel urea breath test for rapid Helicobacter pylori detection and in-office analysis. Eur J Gastroenterol Hepatol 2002;14:513-520   DOI   ScienceOn
9 Newell DG, Hawtin PR, Stacey AR, MacDougall MH, Ruddle AC. Estimation of prevalence of Helicobacter pylori infection in an asymptomatic elderly population comparing [$^_{14}C$] urea breath test and serology. J Clin Pathol 1991;44:385-7   DOI   PUBMED
10 Raju GS, Smith MJ, Morton D, Bardhan KD. Mini-dose (1-microCi) $^{14}C$-urea breath test for the detection of Helicobacter pylori. Am J Gastroenterol 1994;89:1027-31   PUBMED
11 Marshal BJ, Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983;1:1273-5   PUBMED
12 Monteiro L, de Mascarel A, Sarrasqueta AM, Bergey B, Barberis C, Talby P, et al. Diagnosis of Helicobacter pylori infection: noninvasive methods compared to invasive methods and evaluation of two new tests. Am J Gastroenterol 2001;96:353-8   DOI   ScienceOn
13 Peura DA, Pambianco DJ, Dye KR, Lind C, Frierson HF, Hoffman SR, et al. Microdose $^{14}C$-urea breath test offers diagnosis of Helicobacter pylori in 10 minutes. Am J Gastroenterol 1996;91:233-8   PUBMED
14 Thijs JC, Van Zwet AA, Thijs WJ, Oey HB, Karrenbeld A, Stellaard F, et al. Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy, without selecting a single test as the gold standard. Am J Gastroenterol 1996;91:2125-9   PUBMED
15 Gasbarrini A, Franceschi F, Gasbarrini G, Pola P. Extraintestinal pathology associated with Helicobacter infection. Eur J Gastroenterol Hepatol 1997;9:231-3   DOI   PUBMED   ScienceOn
16 Leide-Svegborn S, Stenstrom K, Olofsson M, Mattsson S, Nilsson LE, Nosslin B, et al. Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test. Eur J Nucl Med 1999;26:573-80   DOI   ScienceOn
17 Desroches JJ, Lahaie RG, Picard M, Morais J, Dumont A, Gaudreau C, et al. Methodological validation and clinical usefulness of carbon-14-urea breath test for documentation of presence and eradication of Helicobacter pylori infection. J Nucl Med 1997;38:1141-5