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Chorea in Systemic Lupus Erythematosus: Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET  

Seo, Wook-Jang (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Chung, Son-Mi (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Koh, Su-Jin (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Lee, Chang-Keun (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Kim, Jae-Seung (Department of Nuclear Medicine University of Ulsan College of Medicine, Asan Medical Center)
Im, Joo-Hyuk (Department of Neurology University of Ulsan College of Medicine, Asan Medical Center)
Yoo, Bin (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Moon, Hee-Bom (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Publication Information
The Korean Journal of Nuclear Medicine / v.37, no.5, 2003 , pp. 325-330 More about this Journal
Abstract
Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.
Keywords
Systemic lupus erythematosus; Chorea; F-18 FDG; PET;
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