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The Clinical Usefulness of Tc-99m ECD Brain SPECT in Acute Measles Encephalitis  

Lim, Seok-Tae (Departments of Nuclear Medicine, Chonbuk National University Medical School)
Sohn, Myung-Hee (Departments of Nuclear Medicine, Chonbuk National University Medical School)
Publication Information
The Korean Journal of Nuclear Medicine / v.37, no.4, 2003 , pp. 229-234 More about this Journal
Abstract
Purpose: Since the prognosis of measles encephalitis is poor, early diagnosis and proper management are very important to improve clinical outcomes. We compared Tc-99m ECD brain SPECT (SPECT) with MR imaging (MRI) for the detection of acute measles encephalitis. Materials and Methods: Eleven patients(M : F=4 : 7, age range 18 months-14 yrs) with acute measles encephalitis were enrolled in this studies. All of them underwent both MRI and SPECT. The results of SPECT were scored from 0 (normal) to 3 (most severe defect) according to perfusion state. We compared two image modalities for the detection of brain abnormality in acute measles encephalitis. Results: Seven of 11 patients (63.6%) revealed high signal intensity in the white matter on T2WI of MRI, on the other hand all patients (100%) showed hypoperfusion on SPECT. Severe perfusion deficits above score 2 were located with decreasing frequencies in the frontal lobe (81.8%), temporal lobe (72.7%), occipital lobe (27.3%), basal ganglia (27.3%), and parietal lobe (9.1%). Conclusion: We conclude that SPECT is more useful than MRI for the detection of brain involvement in patients with acute measles encephalitis.
Keywords
Acute measles encephalitis; brain SPECT; Tc-99m ECD;
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