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Development of Gated Myocardial SPECT Analysis Software and Evaluation of Left Ventricular Contraction Function  

Lee, Byeong-Il (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Jae-Sung (Department of Nuclear Medicine, Seoul National University College of Medicine)
Chung, June-Key (Department of Nuclear Medicine, Seoul National University College of Medicine)
Lee, Myung-Chul (Department of Nuclear Medicine, Seoul National University College of Medicine)
Choi, Heung-Kook (Department of Information & Computer Engineering, Inje University)
Publication Information
The Korean Journal of Nuclear Medicine / v.37, no.2, 2003 , pp. 73-82 More about this Journal
Abstract
Objectives: A new software (Cardiac SPECT Analyzer: CSA) was developed for quantification of volumes and election fraction on gated myocardial SPECT. Volumes and ejection fraction by CSA were validated by comparing with those quantified by Quantitative Gated SPECT (QGS) software. Materials and Methods: Gated myocardial SPECT was peformed in 40 patients with ejection fraction from 15% to 85%. In 26 patients, gated myocardial SPECT was acquired again with the patients in situ. A cylinder model was used to eliminate noise semi-automatically and profile data was extracted using Gaussian fitting after smoothing. The boundary points of endo- and epicardium were found using an iterative learning algorithm. Enddiastolic (EDV) and endsystolic volumes (ESV) and election fraction (EF) were calculated. These values were compared with those calculated by QGS and the same gated SPECT data was repeatedly quantified by CSA and variation of the values on sequential measurements of the same patients on the repeated acquisition. Results: From the 40 patient data, EF, EDV and ESV by CSA were correlated with those by QGS with the correlation coefficients of 0.97, 0.92, 0.96. Two standard deviation (SD) of EF on Bland Altman plot was 10.1%. Repeated measurements of EF, EDV, and ESV by CSA were correlated with each other with the coefficients of 0.96, 0.99, and 0.99 for EF, EDV and ESV respectively. On repeated acquisition, reproducibility was also excellent with correlation coefficients of 0.89, 0.97, 0.98, and coefficient of variation of 8.2%, 5.4mL, 8.5mL and 2SD of 10.6%, 21.2mL, and 16.4mL on Bland Altman plot for EF, EDV and ESV. Conclusion: We developed the software of CSA for quantification of volumes and ejection fraction on gated myocardial SPECT. Volumes and ejection fraction quantified using this software was found valid for its correctness and precision.
Keywords
gated myocardial SPECT; quantification; ejection fraction;
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  • Reference
1 Germano G. Technical aspects of myocardial SPECT imaging. J Nucl Med 2001;42:1499-507
2 Germano G, Kavanagh PB, Waechter P, Areeda J, Kriekinge SV, Sharir T, et al. A new algorithm for the quantitation of myocardial perfusion SPECT.I: Technical principles and reproducibility. J Nucl Med 2000;41:712-19
3 Lee DS, Cheon OJ, Ahn JY, Chung JK, Lee Me. Reproducibility of assessment of myocardial function using gated Tc-99m MlBI SPECT and quantitative software. Nucl Med Commun. 2000;21:1127-34
4 Ammeraal L. Computer graphics for java programmers. John Wiley & Sons Ltd 1998
5 http://www.ats.ucla.edu/stat/spss/faqfalpha.htrnl
6 Kim KM, Lee DS, Kim YK, Cheon GJ, Kim SK, Chung JK, et al. Reproducibility of non-invasive measurement for left ventricular contractility using gated myocardial SPECT. Korean J Nucl Med 2001;35:152-60
7 Iskandrian AE, Germano G, VanDecker W, Ogilby JD, Wolf N, Mintz R et aL Validation of left ventricular volume measurements by gated SPEer Tc-99m labeled sestamibi imaging. J Nucl Cardiol 1998;5:574-8
8 Jain R, Kasturi R, Schunck BG. Machine vision. McGraw-Hill Inc International edition. 1995
9 Jaime B. Digital image processing. Springer-Verlag Berlin Heidelberg 1995
10 Lee BI, Lee JS, Lee DS. Regional contractility measurement of the left ventricle using gated myocardial SPECT. Proceedings of IEEE MIC 2002; M10-229
11 Frangi AF. Three-dimensional modeling for functional analysis of cardiac images: A review. IEEE Trans Med Img, 2001;20:2-25
12 Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su H-T, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 1995;36:2138-47
13 Faber TL, Cooke CD, Folks RR, Vansant JP, Nichols KJ, DePuey EG, et al. Left ventricular function and perfusion from gated SPECT perfusion images: An integrated method. J Nucl Med 1999;40:650-59
14 Lichtenbelt B, Crane R, Vaqvi S. Introduction to volume rendering. Prentice Hall Hewlett-Packard Company 1998
15 Nichols K, Santana C, Folks R, Krawczynska E, Cooke D. Comparison between ECTb and QGS for assessment of left ventricu1ar function from gated myocardial perfusion SPEer. J Nucl Med 2002;9:285-93