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Functional Neuroimaging in Epilepsy: FDG-PET and SPECT  

Lee, Sang-Kun (Department of Neurology Seoul National University College of Medicine)
Lee, Dong-Soo (Department of Nuclear Medicine Seoul National University College of Medicine)
Publication Information
The Korean Journal of Nuclear Medicine / v.37, no.1, 2003 , pp. 24-33 More about this Journal
Abstract
Finding epileptogenic zone is the most important step for the successful epilepsy surgery. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and single photon emission computed tomography (SPECT) can be used in the localization of epileptogenic foci. In medial temporal lobe epilepsy, the diagnostic sensitivity of FDG-PET and ictal SPECT is excellent. However, detection of hippocampal sclerosis by MRI is so certain that use of FDG-PET and ictal SPECT in medial temporal lobe epilepsy is limited for some occasions. In neocortical epilepsy, the sensitivities of FDG-PET or ictal SPECT are fair. However, FDG-PET and ictal SPECT can have a crucial role in the localization of epileptogenic foci for non-lesional neocortical epilepsy. Interpretation of FDG-PET has been recently advanced by voxel-based analysis and automatic volume of interest analysis based on a population template. Both analytical methods can aid the objective diagnosis of epileptogenic foci. Ictal SPECT was analyzed using subtraction methods and voxel-based analysis. Rapidity of injection of tracers, ictal EEG findings during injection of tracer, and repeated ictal SPECT were important technical issues of ictal SPECT. SPECT can also be used in the evaluation of validity of Wada test.
Keywords
FDG-PET; SPECT; Epilepsy;
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1 Kutsy RL. Focal extratempora1 epilepsy: clinical features, EEG patterns, and surgical approach. J Neurol Sci 1999;166:1-15
2 Zentner J, Hufnagel A, Ostertun B, Wolf HK, Behrens E, Campos MG, et al. Surgical treatment of extratemporal epilepsy: clinical, radiologic, and histopathologic findings in 60 patients. Epilepsia 1996;37: 1072-80
3 Lee DS, Kim SK, Lee SK, Chung J-K, Lee MC, Koh C-S. Frequencies and implications of discordant fmdings of interictal SPECT and ictal SPECT in patients with intractable epilepsy. Eur J Nucl Med 1997;24:983
4 Lee DS, Lee JS, Kang KW, Jang MI, Lee SK, Chung J-K, et al. Disparity of perfusion and glucose metabolism of epileptogenic zones in temporal lobe epilepsy demonstrated by SPM/SPAM analysis on 15-0 water PET, 18-F-FDG-PET, and 99mTc-HMPAO SPECT. Epilepsia 2001;42:1515-22
5 Van Bogaert P, Massager N, Tugendharft P, Wilder D, Damhaut P, Levivier M, et al. Statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy. Neuroimage 2000;12:129-38
6 Kang KW, Lee DS, Cho JH, Lee JS, Yeo JS, Lee SK, et al. Quantification of F-18 FDG PET images in temporal lobe epilepsy patients using probabilistic brain atlas. Neuroimage 2001;14:1-6
7 Zubal IG, Spanaki MY, MacMullan J, Corsi M, Seibyl JP, Spencer SS. Influence of technetium-99mhexamethylpropylene amine oxime injection time on single-photon emission tomography perfusion changes in epilepsy. Eur J Nucl Med 1999;26:12-7
8 O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Jack CR, et al. Subtraction SPECT co-registered to MRI improves postictal SPECT localization of seizure foci. Neurology 1999;52: 17-46
9 Lee JD, Kim HJ, Lee BI, Kim OJ, Jeon TJ, Kim MJ. Evaluation of ictal brain SPET using statistical parametric mapping in temporal lobe epilepsy. Eur J Nucl Med 2000;27:1658-65
10 Kim BK, Lee SK, Nam H, Song HC, Lee DS. Evaluation of fimctional changes in the medial temporal region during intracarotid amobarbital procedure by use of SPECT. Epilepsia 1999;40:424-429
11 Kim S-K, Lee DS, Lee SK, Kim YK, Kang KW, Chung CK, et al. Diagnostic performance of 18-F-FDG-PET and ictal 99m-Tc-HMPAO SPEer in occipital lobe epilepsy. Epilepsia 2001;42:1531-40
12 Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, et al. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative 18-F FDG PET: a clinical validation of statistical parametric mapping. Neuroimage 1999;9:63-80
13 Lee SK, Lee DS, Yeo JS, Lee JS, Kim YK, Jang MI, et al. FDG-PET images quantified by probabilistic atlas of brain and surgical prognosis of temporal lobe epilepsy. Epilepsia 2002;43:1032-8
14 Nam H, Lee SK, Chung CK, Hong KS, Chang KH, Lee DS. Incidence and clinical profile of extra-medial-temporal epilepsy with hippocampal atrophy. J Korean Med Sci 2001;16:95-102
15 Lee DS, Seo J-M, Lee JS, Lee SK, Kim HJ, Chung J-K, et al. Diagnosis of ictal hyperperfusion using subtraction image of ictal and interictal brain perfusion SPECT. Korean J Nucl Med 1998;32:20-31
16 Lewis PJ, Siegel A, Siegel AM, Studhohne C, Sojkova J, Roberts DW, et al. Does performing inage registration and subtraction in ictal brain SPECT help localize neocortical seizures? J Nucl Med 2000;41:1619-26
17 Spanaki MV, Spencer SS, Corsi M, MacMullan J, Seibyl J, Zubal IG. Sensitivity and specificity of quantitative difference SPECT analysis in seizure localization. J Nucl Med 1999;40:730-6
18 Luders HO, Awad I. Conceptual considerations. In: Luders HO (ed), Epilepsy Surgery. New York, Raven Press, 1992:51-62
19 Lee SK, Lee S-H, Kim S-K, Lee DS, Kim H. The clinical usefulness of ictal SPECT in temporal lobe epilepsy: the lateralization of seizure focus and correlation with EEG. Epilepsia 2000;41:955-62
20 Lee DS, Lee SK, Chung J-K, Kim HJ, Lee MC, Koh C-S. Predictive values of F-18-FDG PET and ictal SPECT to find epileptogenic zones in cryptogenic neocortical epilepsies (Abstrct) J Nucl Med 1997;38:272
21 Kim YK, Lee DS, Lee SK, Chung CK, Chung J-K, Lee MC. 18F-FDG-PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med 2002;43:1167-74
22 Kim BG, Lee SK, Kim JY, Kanf DW, Lee W, Song H, Lee DS. Interpretation of Wada memory test for lateralization of seizure focus by use of 99mTctechnetium- HMPAO SPECT. Epilepsia 2000:41:65-70
23 Lee HW, Hong SB, Tae WS. Opposite ictal perfusion patterns of subtracted SPECT. Hyperperfusion and hypoperfusion. Brain 2000;123:215Q-9
24 Noachtar S, Arnold S, 'Yousry TA, Bartenstein P, Werahn KJ, Tatsch K. Ictal technetium-99m ethylcysteinate diller single-photon emission tomographic findings and propagation of epileptic seizure activity in patients with extratemporal epilepsies. Eur J Nucl Med 1998;25:166-72
25 Lee SK, Choe G, Hong KS, Nam HW, Kim J-Y, Chung C-K, et al. Neuroimaging fmdings of cortical dyslamination with cytomegaly. Epilepsia 2001;42:850-6
26 Lee BI, Lee JD, Kim JY, Ryu YH, Kim WJ, Lee JH, et al. Singlephotonemission computed tomographyEEG relations in temporal lobe epilepsy. Neurology 1997;49:981-91
27 Lee DS, Lee SK, Kim SK, Kang KW, Kang E, Lee KH, et al. Late postictal residual perfusion abnormality in epileptogenic zone found on 6-hour postictal SPECT. Neurology 2000;55:835-41
28 Won HJ, Chang KH, Cheon JE, Kim HD, Lee DS, Han MH, et al. Comparison of MR imaging with PET and ictal SPECT in 118 patients with intractable epilepsy. AJNR 1999;20:593-9
29 Lee DS, Lee SK, Kim YK, Kang E, Lee JS, Chung J-K. The usefulness of repeated ictal SPECT for the localization of epileptogenic zones in intractable epilepsy. Eur J Nucl Med 2002;29:607-14
30 Son YJ, Chung CK, Lee SK, Chang KH, Lee DS, Yi YN et al. Comparison of localizing values of various diagnostic tests in non-lesional medial temporal lobe epilepsy. Seizure 1999;8:465-70