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Evaluation of Striatal Dopamine Transporter Density using $[^{123}I]-{\beta}-CIT$ SPECT in Schizophrenic Patients Treated with Olanzapine: Pilot study  

Kim, Chul-Eung (Departments of Psychiatry, Inha University)
Moon, Hey-Won (Departments of Psychiatry, Inha University)
Choe, Won-Siek (Departments of Nuclear Medicine, Inha University)
Kim, Chang-Ho (Departments of Nuclear Medicine, Inha University)
Chi, Dae-Yoon (Departments of Chemistry, Inha University)
Publication Information
The Korean Journal of Nuclear Medicine / v.36, no.4, 2002 , pp. 224-231 More about this Journal
Abstract
Purpose: This pilot study was performed to understand the pharmacological effect of olanzapine, an atypical antipsychotic agent, on dopamine transporter in schizophrenic patients. Materials and Methods: Six patients (3 male, 3 female) with schizophrenia, who had not taken any psychotropic drugs for at least four weeks, were studied. Nuclear imaging using $[^{123}I]-{\beta}-CIT$ SPECT was obtained before and after 4-week treatment with olanzapine. Analysis of ROI on the striatum, caudate nucleus, and putamen was performed. Results: Post-treatment uptake was significantly increased in all the ROIs compared with pre-treatment uptake. Conclusion: This preliminary study with the small number of schizophrenic patients suggested an increase in uptake of dopamine transporter in the striatum, caudate nucleus, and putamen after 4-week treatment with olanzapine, which warrants a large-scaled controlled study to confirm the current findings.
Keywords
$[^{123}I]-{\beta}-CIT$ SPECT; dopamine transporter; schizophrenia; olanzapine;
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