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http://dx.doi.org/10.14578/jkfs.2011.100.1.3

Enhancement of Anticancer Activity of Acer mono Aqueous Extracts by Nano-Encapsulation Process  

Kim, Ji-Seon (Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Jeong, Myoung-Hoon (Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Choi, Woon-Yong (Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Seo, Yong-Chang (Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Cho, Jeong Sub (DooSan EcoBizNet)
Lee, Hyeon Yong (Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Journal of Korean Society of Forest Science / v.100, no.1, 2011 , pp. 14-24 More about this Journal
Abstract
Anticancer activity of Acer mono aqueous extracts was enhanced by nano-encapsulation process of gelatin. The cytotoxicity on human normal lung cell (HEL299) of the extracts from WE (water extract at 100) showed 23.51%, lower than that from NE (nano-encapsulatioin of water extract of Acer mono) in adding the maximum concentration of 1.0 mg/mL. NE showed more potent scavenging effect as 73.15% than the WE. On SOD-like test, the NE showed highest activity as 32.33% at 1.0 mg/mL concentration. Human stomach adenocarcinoma, liver adenocarcinoma, breast adenocarcinoma and lung adenocarcinoma cell growth were inhibited up to about 59-73%, in adding 1.0 mg/mL of NE. NE was 15% higher than conventional water extraction. Among several cancer cell lines (stomach adenocarcinoma, liver adenocarcinoma), the growth of digestive related cancer cells were most effectively inhibited as about 71-73%. The size of nano particles was in the ranges of 100-200 nm, which can effectively the penetrate into the cells, it was observed by real time confocal microscope. It tells that the aqueous extracts of Acer mono bark could be definitely enhanced by nano-encapsulation process.
Keywords
Acer mono; Anticancer activity; Nano-encapsulation process;
Citations & Related Records
Times Cited By KSCI : 13  (Citation Analysis)
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