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http://dx.doi.org/10.6109/jkiice.2008.12.2.315

The Implement of System on Microarry Classification Using Combination of Signigicant Gene Selection Method  

Park, Su-Young (조선대학교 컴퓨터통계학과)
Jung, Chai-Yeoung (조선대학교 컴퓨터통계학과)
Publication Information
Journal of the Korea Institute of Information and Communication Engineering / v.12, no.2, 2008 , pp. 315-320 More about this Journal
Abstract
Nowadays, a lot of related data obtained from these research could be given a new present meaning to accomplish the original purpose of the whole research as a human genome project. In such a thread, construction of gene expression analysis system and a basis rank analysis system is being watched newly. Recently, being identified fact that particular sub-class of tumor be related with particular chromosome, microarray started to be used in diagnosis field by doing cancer classification and predication based on gene expression information. In this thesis, we used cDNA microarrays of 3840 genes obtained from neuronal differentiation experiment of cortical stem cells on white mouse with cancer, created system that can extract informative gene list through normalization separately and proposed combination method for selecting more significant genes. And possibility of proposed system and method is verified through experiment. That result is that PC-ED combination represent 98.74% accurate and 0.04% MSE, which show that it improve classification performance than case to experiment after generating gene list using single similarity scale.
Keywords
microarray; PC-ED combination method; MLP(Multi-Perceptron);
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