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http://dx.doi.org/10.13048/jkm.22027

The Retrospective Study of Advanced Cancer Patients Receiving Integrative Cancer Treatments in single Comprehensive and Integrative Medicine Hospital  

Jeonghyun Joo (Integrative Cancer Center, CHA University Ilsan Medical Center )
Songha Chon (Integrative Cancer Center, CHA University Ilsan Medical Center )
Kicheul Sohn (Department of Preventive Medicine, Daegu Catholic University Medical Center)
Sanghun Lee (Department of Bioconvergence & Engineering, Graduate school, Dankook University)
Publication Information
The Journal of Korean Medicine / v.43, no.3, 2022 , pp. 16-26 More about this Journal
Abstract
Objectives: Traditional Korean medicine (TKM) has been supplied as part of a national health care system in South Korea under a dual medical system, however it has been difficult to mix western medicine and TKM medical practices in existing hospitals. For the objective of innovative integration between them, Comprehensive and Integrative Medicine Hospital were founded in Daegu, South Korea. Here, we discussed the clinical outcomes of cancer patients who received integrative cancer treatment (ICT). Methods: A total of 678 patients previously diagnosed with cancer were retrospectively checked in our institution for 2 years. After applying inclusion/exclusion criteria, 573 patients were eligible for the final analysis. The overall survival (OS) of these patients in the aftercare period were determined. We looked at how clinical factors and treatments including chemotherapy, complementary and alternative medicine (CAM), and TKM affected the OS. Results: At the first visit, 212 subjects had no evidence of disease after tumor resection and 355 ones with advanced cancer, who receiving ICT including chemotherapy, CAM, and TKM showed better OS compared to the CAM including TKM or the best supportive care (median OS = 216, 78, and 46 days, respectively). The median OS was not reached in TKM only, even though the sample size was small (N=12). Even after adjusting for clinical factors associated to liver, renal, and hematologic manifestation, ICT still remained significant. Conclusions: We demonstrated that ICT might be beneficial for advanced cancer regardless of the performance status, liver and renal function, since it positively affected the OS.
Keywords
Advanced cancer; Traditional Korean medicine; Integrative cancer treatment; Complementary and alternative medicine; Overall Survival;
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Times Cited By KSCI : 6  (Citation Analysis)
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1 Zhang, Q.Sharan, A.Espinosa, S. A.Gallego-Perez, D. & Weeks, J. (2019). The path toward integration of traditional and complementary medicine into health systems globally: The world health organization report on the implementation of the 2014-2023 strategy. J Altern Complement Med. 25(9). 869-871. 10.1089/acm.2019.29077.jjw   DOI
2 Brinkhaus, B. (2010). New perspectives in medicine are required - from cam to integrative medicine. Forsch Komplementmed. 17(4). 216. 10.1159/000295165   DOI
3 Yun, H.Sun, L. & Mao, J. J. (2017). Growth of integrative medicine at leading cancer centers between 2009 and 2016: A systematic analysis of nci-designated comprehensive cancer center websites. J Natl Cancer Inst Monogr. 2017(52). 10.1093/jncimonographs/lgx004   DOI
4 Desai, K.Liou, K.Liang, K.Seluzicki, C. & Mao, J. J. (2021). Availability of integrative medicine therapies at national cancer institute-designated comprehensive cancer centers and community hospitals. J Altern Complement Med. 27(11). 1011-1013. 10.1089/acm.2021.0102   DOI
5 Deng, G. E., Rausch, S. M., Jones, L. W., Gulati, A., Kumar, N. B., Greenlee, H., et al. (2013). Complementary therapies and integrative medicine in lung cancer: Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 143(5 Suppl). e420S-e436S. 10.1378/chest.12-2364   DOI
6 Greenlee, H., DuPont-Reyes, M. J., Balneaves, L. G., Carlson, L. E., Cohen, M. R., Deng, G., et al. (2017). Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 67(3). 194-232. 10.3322/caac.21397   DOI
7 Park, J.Yi, E. & Yi, J. (2021). The provision and utilization of traditional korean medicine in south korea: Implications on integration of traditional medicine in a developed country. Healthcare (Basel). 9(10). 10.3390/healthcare9101379   DOI
8 Lee, S.Joo, J. & Chon, S. (2018). Successful outcome of an elderly patient with small cell lung cancer with only alternative treatments: A case report. The Journal of Korean Medicine. 39(4). 171-176. http://dx.doi.org/10.13048/jkm.18043   DOI
9 Lee, S.Sohn, K. & Chon, S. (2018). Successful outcome of breast cancer patient refusing conventional treatments: A case report. The Journal of Korean Medicine. 39(4). 177-182. http://dx.doi.org/10.13048/ jkm.18044   DOI
10 Garaci, E., Pica, F., Serafino, A., Balestrieri, E., Matteucci, C., Moroni, G., et al. (2012). Thymosin alpha1 and cancer: Action on immune effector and tumor target cells. Ann N Y Acad Sci. 1269(26-33). 10.1111/j.1749-6632.2012.06697.x   DOI
11 Bottger, F.Valles-Marti, A.Cahn, L. & Jimenez, C. R. (2021). High-dose intravenous vitamin c, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res. 40(1). 343. 10.1186/s13046 -021-02134-y   DOI
12 Evans, M.Bryant, S.Huntley, A. L. & Feder, G. (2016). Cancer patients' experiences of using mistletoe (viscum album): A qualitative systematic review and synthesis. J Altern Complement Med. 22(2). 134-144. 10.1089/acm.2015.0194   DOI
13 Barchielli, G.Capperucci, A. & Tanini, D. (2022). The role of selenium in pathologies: An updated review. Antioxidants (Basel). 11(2). 10.3390/antiox 11020251   DOI
14 Kennedy, L.Sandhu, J. K.Harper, M. E. & Cuperlovic-Culf, M. (2020). Role of glutathione in cancer: From mechanisms to therapies. Biomolecules. 10(10). 10.3390/biom10101429   DOI
15 Cheng, Y., Weng, S., Yu, L., Zhu, N., Yang, M. & Yuan, Y. (2019). The role of hyperthermia in the multidisciplinary treatment of malignant tumors. Integr Cancer Ther. 18(1534735419876345. 10.1177/1534735419876345   DOI
16 Survey report on utilization of traditional korean medicine 2020. National Institute of Korean Medicine Development, Korean Ministry of Health and Welfare. https://www.koms.or.kr/board/researchReport/view.do?post_no=161&menu_no=21.
17 Jung, K. W.Won, Y. J.Kong, H. J. & Lee, E. S. (2019). Cancer statistics in korea: Incidence, mortality, survival, and prevalence in 2016. Cancer Res Treat. 51(2). 417-430. 10.4143/crt.2019.138   DOI
18 Bae, K.Kim, E.Choi, J. J.Kim, M. K. & Yoo, H. S. (2018). The effectiveness of anticancer traditional korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer: A prospective cohort study protocol. Medicine (Baltimore). 97(41). e12444. 10.1097/MD.0000000000012444   DOI
19 Kim, Y. (2014). Towards universal coverage: An evaluation of the benefit enhancement plan for four major conditions in korean national health insurance. J Korean Med Assoc. 57(3). 198-203. 10.5124/jkma.2014.57.3.198   DOI
20 Choi, W., Jung, H., Kim, K., Lee, S., Yoon, S., Park, J., et al. (2012). Rhus verniciflua stokes against advanced cancer: A perspective from the korean integrative cancer center. J Biomed Biotechnol. 2012(874276. 10.1155/2012/874276   DOI
21 Hung, K. F., Hsu, C. P., Chiang, J. H., Lin, H. J., Kuo, Y. T., Sun, M. F., et al. (2017). Complementary chinese herbal medicine therapy improves survival of patients with gastric cancer in taiwan: A nationwide retrospective matched-cohort study. J Ethnopharmacol. 199 (168-174). 10.1016/j.jep.2017.02.004   DOI
22 Wang, C. Y., Huang, H. S., Su, Y. C., Tu, C. Y., Hsia, T. C. & Huang, S. T. (2018). Conventional treatment integrated with chinese herbal medicine improves the survival rate of patients with advanced non-small cell lung cancer. Complement Ther Med. 40(29-36. 10.1016/j.ctim.2018.07.003   DOI
23 Ling, C. Q., Fan, J., Lin, H. S., Shen, F., Xu, Z. Y., Lin, L. Z., et al. (2018). Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional chinese and western medicine. J Integr Med. 16(4). 236-248. 10.1016/j.joim.2018.05.002   DOI
24 Yeh, M. H., Chiu, H. P., Wu, M. C., Koo, M., Lin, N. W., Liao, K. K., et al. (2020). Integrated chinese herbal medicine and western medicine on the survival in patients with colorectal cancer: A retrospective study of medical records. Evid Based Complement Alternat Med. 2020(456-1040). 10.1155/2020/4561040   DOI
25 Lee, Y. C.Chen, Y. H.Huang, Y. C.Lee, Y. F. & Tsai, M. Y. (2020). Effectiveness of combined treatment with traditional chinese medicine and western medicine on the prognosis of patients with breast cancer. J Altern Complement Med. 26(9). 833-840. 10.1089/acm.2019.0200   DOI
26 Euser, A. M.Zoccali, C.Jager, K. J. & Dekker, F. W. (2009). Cohort studies: Prospective versus retrospective. Nephron Clin Pract. 113(3). c214-217. 10.1159/000235241    DOI
27 Bae, K., Kim, E., Kong, J. S., Kim, J., Park, S. J., Jun, H. J., et al. (2019). Integrative cancer treatment may have a survival benefit in patients with lung cancer: A retrospective cohort study from an integrative cancer center in korea. Medicine (Baltimore). 98(26). e16048. 10.1097/MD.0000000000016048   DOI
28 Wang, Y., Liu, P., Fang, Y., Tian, J., Li, S., Xu, J., et al. (2020). The effect of long-term traditional chinese medicine treatment on survival time of colorectal cancer based on propensity score matching: A retrospective cohort study. Evid Based Complement Alternat Med. 2020(702-3420. 10.1155/2020/7023420   DOI
29 Yeh, M. H., Wu, H. C., Lin, N. W., Hsieh, J. J., Yeh, J. W., Chiu, H. P., et al. (2020). Long-term use of combined conventional medicine and chinese herbal medicine decreases the mortality risk of patients with lung cancer. Complement Ther Med. 52(102-427). 10.1016/j.ctim.2020.102427   DOI