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http://dx.doi.org/10.13048/jkm.19041

Effects of Yuhyangjeongtong-san on Fracture Healing in Rats  

Kim, Ki-Tae (Dept. of Internal Medicine, Je-Cheon Hospital of Traditional Korean Medicine, Semyung University)
Jo, Na-Young (Dept. of Acupuncture & Moxibustion Medicine, Je-Cheon Hospital of Traditional Korean Medicine, Semyung University)
Publication Information
The Journal of Korean Medicine / v.40, no.4, 2019 , pp. 61-71 More about this Journal
Abstract
Objectives: The purpose of this study is to determine the effect of Yuhyangjeongtong-san on the recovery of tibial fractures in rats. Methods: In this study, osteocalcin and Calcitonin, CTX-2, TGF-β and BMP-2, which are used as indicators of bone formation, were analyzed after hematologic fractures using experimental rats. In addition, the fracture union process was confirmed using X-rays. Results: Osteocalcin, Calcitonin and BMP-2 showed a significant increase compared with the control at 4 weeks. CTX-2 and TGF-β showed a significant increase compared with the control at 3 weeks. On X-ray, YJS treated group, as the experiment progressed, the boundary line became blurred, the bone outline was clearly visible, and the fracture recover was progressing. Conclusion: The findings suggest that YJS can play a significant role in the repair of fractures. Therefore YJS is likely to be used to treat fractures.
Keywords
Yuhyangjeongtong-san; Fracture; Rat; Tibia; Korean medicine;
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Times Cited By KSCI : 4  (Citation Analysis)
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