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http://dx.doi.org/10.13048/jkm.18031

Hypothesis Proposal about Predictive Factors and Optimal Age for Response to Herbal Medicine Treatment for Height Gain in Children: a Retrospective Review  

Leem, Jungtae (Department of Internal Medicine of Korean Medicine, Dongshin Korean Medicine Hospital)
Kim, Jeeyeun (Aijoafamily Korean Medical Clinic Network)
Suh, Kyeungsuk (Aijoafamily Korean Medical Clinic Network)
Lim, Youngkwern (Aijoafamily Korean Medical Clinic Network)
Lee, Junhee (Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital)
Publication Information
The Journal of Korean Medicine / v.39, no.4, 2018 , pp. 16-29 More about this Journal
Abstract
Introduction: We aimed to investigate the predictive factors and optimal age for response to herbal medicine treatment for height gain in children. Methods: This retrospective chart review included 61 children (age range, 5-16 years) treated for height gain between 2011 and 2015. A predictive model was established by multiple linear regression analysis. Dependent variables were defined by the differences in percentile before and after herbal medicine treatment. The optimal cutoff value of patient age was determined by receiver operating curve analysis. Results : The age of initiation of herbal medicine therapy (p = 0.012) and administration of Forsythiae fructus (p = 0.002) were significant variables for treatment response. The adjusted R2 value was 0.231. The mean ages of the responder and non-responder groups were significantly different (p = 0.023). The optimal cutoff value of age for predicting treatment response was 9.75 years. Treatment response was better among children below 9.75 years of age. Conclusions: Patient age and administration of Forsythiae fructus were identified as determinants of response to herbal medicine treatment. Treatment of rhinitis and initiation of height gain treatment at an early age are critical for better response. These findings will provide fundamental data for further research.
Keywords
Herbal medicine; Retrospective studies; Height gain; Height percentile; Children; Phytotherapy;
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