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http://dx.doi.org/10.13048/jkm.16009

The Effect of Jeokbaekhaogwanjung-tang Herbal Acupuncture Solution on the Immune Activity of Spleen Cells of Aged Rats  

Lee, Hyun-Suk (Department of Meridians & Acupoints, College of korean Medicine, Daejeon University)
Choi, Kang-Min (Department of Meridians & Acupoints, College of korean Medicine, Daejeon University)
Yim, Yun-Kyoung (Department of Meridians & Acupoints, College of korean Medicine, Daejeon University)
Publication Information
The Journal of Korean Medicine / v.37, no.1, 2016 , pp. 90-100 More about this Journal
Abstract
Objectives: The purpose of this study was to investigate the effect of Jeokbaekhaogwanjung-tang (JGT) distillate on the immune activity of spleen cells of aged rats. Methods: Spleen cells of 10w, 52w 72w old SD rats were cultured and treated with JGT distillate and the levels of IL-2, IL-4, IL-10 and IFN-${\gamma}$ were measured. Results: 1. The levels of IL-2 and IFN-${\gamma}$ in the spleen cells of 52w old rats were significantly decreased by JGT treatment. 2. The level of IFN-${\gamma}$ in the spleen cells of 72w old rats were significantly decreased by JGT treatment. Conclusion: These results suggest that Jeokbaekhaogwanjung-tang distillate has an immune regulative effect by way of suppressing the change of immune activity caused by aging in rats.
Keywords
Jeokbaekhaogwanjung-tang; immune activity; spleen cells; cytokine; aged rats;
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