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http://dx.doi.org/10.13048/jkm.15021

Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats  

Lee, Jeong-Yun (Department of Meridian & Acupoint, College of korean Medicine, Daejeon University)
Jang, Seung-Hoon (Department of Meridian & Acupoint, College of korean Medicine, Daejeon University)
Jeon, Jong-Ik (Department of Meridian & Acupoint, College of korean Medicine, Daejeon University)
Yim, Yun-Kyoung (Department of Meridian & Acupoint, College of korean Medicine, Daejeon University)
Publication Information
The Journal of Korean Medicine / v.36, no.3, 2015 , pp. 73-83 More about this Journal
Abstract
Objectives: The purpose of this study was to evaluate the effects of Polyporus Herbal-acupuncture(PO-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats. Methods: Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with Saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, tumor necrosis factor-alpha (TNF-${\alpha}$), cytokine-induced neutrophil chemoattractant 1(CINC-1) in serum, urinary volume, creatinine, total protein in urine, myeloperoxidase(MPO) in kidney were measured. Results: PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-${\alpha}$, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats. Conclusions: According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
Keywords
LPS-induced nephritis; Polyporus Herbal-acupuncture; KI10;
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