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Review of Pharmacological Effects of Coptidis Rhizoma and its Bioactive Compounds  

Kim, Ki Bae (Department of Internal Medicine, School of Korean Medicine, Pusan National University)
Lee, Hyung Tak (Department of Internal Medicine, School of Korean Medicine, Pusan National University)
Ku, Kyung Howi (Department of Internal Medicine, School of Korean Medicine, Pusan National University)
Hong, Jin Woo (Department of Internal Medicine, School of Korean Medicine, Pusan National University)
Cho, Su In (Division of Pharmacology, School of Korean Medicine, Pusan National University)
Publication Information
The Journal of Korean Medicine / v.33, no.3, 2012 , pp. 160-183 More about this Journal
Abstract
Objectives: Coptidis Rhizoma is one of the most popular and multi-purpose herbs in traditional medicine. The purpose of this study was to contribute to research and applications of Coptidis Rhizoma in clinic, by analyzing and reviewing international studies on its chemical compositions and pharmacological effects. Methods: This study analyzed 344 articles published from 2000 to 2010 in PubMed, Refworks, Riss, and KTKP. The search keywords were "Coptis chinensis", "Coptis japonica", "Coptidis Rhizoma", "huanglian" and "huanglian in Chinese". From them, we selected 114 articles which met our inclusion criteria. Results: This study reviewed 114 articles on Coptidis Rhizoma and its active components in terms of 'Active components', 'Experimental studies', 'Clinical studies', 'Industrial use' and 'Side Effects/Toxicity'. Conclusions: The active components of Coptidis Rhizoma are berberine, coptisine, epiberberine, palmatine, jateorrhizine, magnoflorine, worenine, etc. It is reported that Coptidis Rhizoma and its active components have anti-inflammatory, antibacterial, antitumor, and antioxidant activity, and cardiovascular, hepatoprotective, antidiabetic, neuroprotective, gastrointestinal, pain relieving, discharge phlegm and metrocyte proliferation effects. Moreover, we found that Coptidis Rhizoma can be used for bath preparation, cosmetic products and as a natural antimicrobial substance.
Keywords
Coptis chinensis; Coptis japonica; Coptidis Rhizoma; huanglian; berberine; coptisine;
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