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Anti-Myelosuppression Effects of Korean Red Ginseng in SD Rat Injected with 5-fluorouracil  

Park, Hye-Jung (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Han, Jong-Min (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Kim, Hyeong-Geug (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Choi, Min-Kyung (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Lee, Jin-Seok (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Son, Chang-Gue (Liver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Publication Information
The Journal of Korean Medicine / v.33, no.2, 2012 , pp. 47-55 More about this Journal
Abstract
Objectives: This study aimed to investigate the preventive effect of red ginseng (RG) on 5-fluorouracil (5-FU)-induced side effects focusing on myelosuppression. Methods: Rats (n = 50) were divided into five groups, nave, control (ip, 5-FU injection of 150 mg/kg), and RG pre-treatment (po, 25, 50 and 100 mg/kg for 5 days before 5-FU injection). On the $7^{th}$ day after 5-FU injection, we evaluated the effects using peripheral hematological parameters, colony-forming assay, cytokine levels and histopathological finding. Results: The peripheral white blood cell and the differential count were dramatically suppressed by 5-FU, while RG (50 and 100 mg/kg) treatment significantly improved total white blood cell, neutrophil, lymphocyte and platelet counts. Also, RG (100 mg/kg) pre-treatment significantly increased the number of CFU-GM colony compared with the control group. RG pre-treatment also ameliorated the histopathological damage in bone marrow, spleen, stomach and small intestine tissue. Conclusions: These results demonstrate that Korean RG has preventive effects against 5-FU-induced myelotoxicity and gastrointestinal damage.
Keywords
Red ginseng; 5-fluorouracil; Myelosuppression; Side effect; Chemotherapy;
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