Browse > Article

Experimental Studies on the Antidiarrheal Effects of Anjang-san  

Oh, Seung-Whan (Kyung Hee University Graduate School of Oriental Medicine)
Ryu, Bong-Ha (3rd Department of Internal Medicine, Kyung Hee University Oriental Medicine Hospital)
Publication Information
The Journal of Korean Medicine / v.32, no.6, 2011 , pp. 54-66 More about this Journal
Abstract
Objectives: The purpose of the present study was to investigate the antidiarrheal effects of Anjang-san in mice and rats. Methods: We measured the content of condensed tannin in Anjang-san extract, and observed the effects of Anjang-san on the small intestinal and colonic transport of mice, as well as on mice models of diarrhea induced by castor oil and $MgSO_4$, and on rat models of castor oil-induced enteropooling. Results: Anjang-san showed significant inhibitory effects on abnormally increased small intestinal transit induced by pyridostigmine and neostigmine, and inhibitory effects on large intestinal transit. Anjang-san also exhibited antidiarrheal effects on diarrhea induced by $MgSO_4$, and inhibitory effects on castor oil-induced enteropooling. Anjang-san also improved castor oil-induced diarrhea based on simple numbers without statistical significance. Conclusion: These results demonstrate that Anjang-san has significant antidiarrheal properties and attests to its possible utility in functional diarrheas, irritable bowel syndrome and other gastrointestinal disorders based upon further studies.
Keywords
Anjang-san; antidiarrheal; diarrhea;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Woo WS. Research method of Chemistry of Natural Products. Seoul: Mineumsa. 1984:117
2 Hong ND, Kim NJ. Development and usage of medical products from natural products. Yakup Daily. 2009;192
3 Association of Chemistry of natural products. Chemistry of natural products. Seoul: Younglimsa. 1995:289-291
4 Okuda T, Ito H. Tannins of constant structure in medicinal and food plants-Hydrolyzable and polyphenols related to tannins. Molecules. 2011; 16;2191-2217   DOI
5 Han DS. Pharmacology. Seoul: Pharmacist Research. 1976:139
6 Goodman JL, Gilman A. Goodman and Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill. 2005:1261
7 Yamamoto K, Takase H, Abe K, Saito Y, Suzuki A. Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba. Folia pharmacol. japon. 1993; 101:169- 175   DOI   ScienceOn
8 Stewart JJ, Gaginella TS, Olsen WA, Bass P. Inhibitory actions of laxatives on motility and water and electrolyte transport in the gastrointestinaltract. J. Pharmacol. Exp. Ther. 1975; 192:458-467
9 Ataka K, Ito M, Shibata T. New views on antidiarrheal effect of wood creosote: Is wood creosote really a gastrointestinal antispetic? Yakugaku Zasshi. 2005; 125:937-950   DOI   ScienceOn
10 Ammon HV, Thomas PJ, Phillips S. Effect of oleic and ricinoleic acid on net jejunal water and electrolyte movement. J. Clin. Invest. 1974; 53:374-379   DOI
11 Robert A, Nezamis JE, Lancaser C, Hanchar AJ, Klepper MS. Enteropooling assay; a test for diarrhea produced by prostaglandins. Prostaglandins. 1976; 11(5):809-828   DOI   ScienceOn
12 Mascolo N, Izzo AA, Avtore G, Barboto F, Capasso F. Nitric oxide and castor oil induced diarrhea. J. Pharmacol. Exper. Thera. 1994; 268: 291-293
13 Ofuji K, Hara H, Sukamoto T, Yamashita S. Effects of an antidiarrhoeica containing an extract from geranium herb on astringent action and short-circuit current across jejunal mucosa. Nihon Yakurigaku Zasshi. 1998; 111(4):265-75.   DOI   ScienceOn
14 Wang LM, Lu CF, Lu YZ, Fu ZZ, Liu Z. Antidiarrhea effect of Herba Geranium tannins. Heilongjiang Medicine and Pharmacy. 2003; 26(5):28-29
15 Song H. Research progress of pharmacological effects of Geranium wilfordii. Chinese Traditional and Herbal Drugs. 1997; 28:132-133
16 Li ZX, Wang XH, Yue YS, Zhao BZ, Chen JB, Li JH. Anti-bacterial effect of Terminalia chebula on 355 clinical strains in vitro. Chinese Journal of Traditional Medical Science and Technology. 2000; 7(6):393-394
17 Na DQ, Wei QD, Zhao H, Na ZY, Li HL. Experimental study of bacteriostasis of Geranium wilfordii soft extract in vivo and in vitro and acute toxicity test. Chinese Journal of Ethnomedicine and Ethnopharmacy. 1998;34: 32-35
18 Korean association of college of oriental medicine, Herbology. Herbology. Seoul: Younglimsa. 1994: 297, 539, 540, 542, 611, 612
19 Seo BI, Choi HY. Clinical oriental medical herbology. Seoul: Younglimsa. 2004:389, 785, 787, 792, 915
20 Sato Y, Oketan Hi, Singyouchi K, Ohtsubo T, Kihara M, Shibata H et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillinresistant Staphylococcus aureus. Biological & Pharmaceutical Bulletin. 1997; 20(4):401-404   DOI   ScienceOn
21 Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans-antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002; 24(10):675-80.   DOI   ScienceOn
22 Weissinger J. Effect of nutmeg, aspirin, chlorpromazine and lithium on normal intestinal transport. Proceedings of the Western Pharmacology Society. 1985; 28:287-293
23 Association of oriental pharmacology. Oriental pharmacology. Seoul: Shinil Books. 2006:115, 135, 529, 568, 602, 621, 635
24 Kim NJ, Hong ND. Quality control of herbal medicine. Seoul: Shinil Books. 2007:370, 408, 417
25 Association of Pharmacognosy. Contemporary pharmacognosy. Seoul: Hakchangsa. 1992:236
26 Ryu IS, Ryu BH, Kim JS. Experimental Studies on the Anti-diarrhea Effects of Jisa-tang. Korean J. Orient. Int. Med. 2008; 29(2):348-58
27 Kim JR. Gastrointestinal diseases. Seoul: Iljogak. 2000:52-62
28 Korean association of college of oriental medicine, Department of internal medicine (spleen system). Internal medicine (spleen system). Seoul: Koonja.2008:177-88
29 Ryu BH, Jang IK. Experimental studies on the effects of Yukgunja-tang. Bulletin of Kyung Hee University. 1984; 7:53-71
30 No WS, Ryu BH, Kim JS, Yoon SH. Experimental Studies on the Anti-cathartic Effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang. Korean J. Orient. Int. Med. 2006; 27(2):356-70
31 Broadhurst R, Jones W. Analysis of condensed tannins using acidified vanillin. J. Sci. Fd. Agric. 1978; 29:788-794   DOI
32 Sagar L, Sehgal R, Ojha S. Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC Com. Alter. Med. 2005; 5(18):1-6
33 Ishi Y, Tanizawa H, Ikemoto C, Takino Y. Studies of Aloe. I. Cathartic Effects. Yakugaku Zasshi. 1981; 101(3):254-258
34 Ishi Y, Tanizawa H, Takino Y. Studies of Aloe. II. Mechanism of Cathritic Effect. Yakugaku Zasshi. 1988; 108(9):904-910
35 Saitoh K, Kase Y, Ishige A, Komatsu A, Sasaki H, Shibata N. Effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Yao-Tang) on diarrhea and small intestinal movement. Bio. Pharm. Bull. 1999; 22:87-89   DOI   ScienceOn
36 Miyawaki Y, Chin M, Yagi T, Yamaguchi K, Kuwano S. Purgative activity of Daio-kanzo-to (Da-Huang-Gan-Cao-Tang) in rats-potentiating effect of glycyrrhiza on the purgative action of rhubarb. J. Med. and Pharm. Soci. for WAKAYAKU. 1993; 10:97
37 Havagiray RC, Ramesh C, Dadhna K. Studies on anti-diarrheal activity of Calotropis gigantea R.BR in experimental animals. J. Pharmaceut Sci. 2004;7:70-75
38 Perianayagam JB, Narayanan S, Gnanasekar G, Pandurangan A, Raja S, Rajagopal K, et al. Evaluation of antidiarrheal potential of Emblica officinalis. Pharmaceutical Biology. 2005; 43:373-377   DOI   ScienceOn
39 Choi HJ. Diarrhea -Focusing on the mechanism-. Korean J Gastroenterol. 1973; Spring symposium: 33-37
40 Song IS. Chronic diarrhea. Korean J Gastroenterol. 2002; 14th seminar:46
41 Heo J. Donguibogam. Seoul: Namsandang. 1991: 150
42 Lee SH, Lee BY. Consideration of Literatures on diarrhea's etiological cause and pathological alternation, and the treatment of diarrhea with Acupuncture ＆ Moxibustion therapy. Bulletin of Research Institute of Korean Medicine, Daejon. 1998; 6(2):627-648
43 Cao X. Sheng Ji Zong Lu. Beijing: People's Medical Publishing House. 1962:1318-1331
44 Korean association of oriental medical physiology. Oriental medical physiology. Seoul: Kyung Hee University Publishing House. 1993:139-141
45 Song DS. Experimental studies on the efficacy of Samryungbaekchulsan. J Korean Oriental Med. 1993; 14(1):179-195
46 Jang TS, Jung HC, Ryu BH. A comparative study on the symptoms and complications between diabetes-mellitus and so-gal. Korean J. Orient. Int. Med. 1985; 2(1):61-69
47 Han KE, Jang IK. Experimental studies on the efficacy of Pyungjin-tang. J Korean Oriental Med. 1991; 12(1):276-298.
48 Jeon WH. Effects of Jeongjangbobi-tang on gastrointestinal function and inhibition of gastric cancer cell proliferation. Bulletin of Kyung Hee University. 2000; 23(1):17-34
49 Ahn JR. Experimental Studies on the Effects of Kamikwakjeongtang. J Korean Oriental Med.1994; 15(2):184-197
50 Kang JC. An experimental research of the efficacy of Youryungtang. J Korean Oriental Med. 1993; 14(1):157-168
51 Chun JH. Experimental studies on the effects of Bojanggunbitang. J Korean Oriental Med. 1994; 15(1):83-99
52 Kong HS. Experimental studies on the efficacy of Siljangsan. Korean J. Orient. Int. Med. 1995; 15(2):197-208
53 Jung WY. The efficiency of Jungritang on gastrointestinal organs of rats. Bulletin of Kyung Hee University. 1998; 21(1):213-223
54 Kim YG. A Study on the Effects of Pyungwee-san in the Movement of Gastrointestinal Smooth Muscles, Anticatharsis, and Central Nervous System. Bulletin of Kyung Hee University. 1999; 22(1): 185-202
55 Shin MK. Colored clinical herbology. Seoul: Younglimsa. 1992:337
56 Lee KM. Anticathartic Effect of Myristicae semen, Granati pericarpium and Alpiniae katsumadai semen. Korean J. Orient. Int. Med. 2006; 27(2):459-470
57 Society of Pharmaceutical Botany. Experimental Pharmaceutical Botany. Seoul: Korean Learning Material Publishing House. 1980:219