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Anti-Glycemic and Anti-Lipid Effect of Ethanol Extract of Supungsunkihwan-gagambang in High Fat Diet-induced Obese Mice  

Song, Sang-Yel (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
Ahn, Se-Young (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
Ahn, Young-Min (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
Um, Jae-Young (Dept. of Pharmacology, College of Oriental Medicine, Kyung Hee University)
Jang, Hyeung-Jin (Dept. of Biochemistry, College of Oriental Medicine, Kyung Hee University)
Lee, Byung-Cheol (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
Publication Information
The Journal of Korean Medicine / v.32, no.5, 2011 , pp. 1-11 More about this Journal
Abstract
Objectives: This study was undertaken to evaluate anti-glycemic and anti-lipid effects of Supungsunkihwan-gagambang, which is composed of Cornus officinalis, Dioscorea Batatas Decaisne, Auantii fructus and Platicodon grandiflorum. Methods: Diabetes was induced in ICR male mice ($24{\pm}1g$) with Surwit's high fat and high sucrose diet. Mice were divided into 3 groups (n=10) of normal, control and Supungsunkihwan-gagambang. The Supungsunkihwan-gagambang group was given 5% herbal medicine in their diet. The animals were fed on each experimental diet for 8 weeks. Body weight was assessed every week. At the 7th week, the fasting blood sugar (FBS) and oral glucose tolerance test (OGTT) were conducted in all experimental groups. After 8 weeks, fructosamine, lipid profile, epididymal fat weight, liver weight and white adipose tissue (WAT) size were measured. Results: Supungsunkihwan-gagambang significantly reduced FBS, OGTT and fructosamine. It also increased high density lipoprotein (HDL) cholesterol and significantly reduced triglyceride/HDL cholesterol ratio, total cholesterol/HDL cholesterol ratio and WAT size. Conclusions: These results show that Supungsunkihwan-gagambang improves anti-glycemic and anti-lipid effect in high fat diet-induced obese mice. Therefore we suggest that Supungsunkihwan-gagambang could be an effective treatment for patients with type 2 diabetes.
Keywords
Supungsunkihwan-gagambang; Cornus officinalis; Dioscorea Batatas Decaisne; Auantii fructus; Platicodon grandiflorum; type 2 diabetes;
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