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Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury  

Lee, Ju-Guan (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
Yang, Su-Young (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
Kim, Min-Hee (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
NamGung, Uk (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
Park, Yang-Chun (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
Publication Information
The Journal of Korean Medicine / v.32, no.4, 2011 , pp. 83-99 More about this Journal
Abstract
Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
Keywords
Socheongryong-tang; chronic obstructive pulmonary disease; A549 cell; elastase;
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Times Cited By KSCI : 11  (Citation Analysis)
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