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Effects of Choweseuncheng-tang on Obesity and Hyperlipidemia in High-fat-diet-induced Obese Mice  

Lee, Mi-Jung (Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University)
Yang, Ga-Eun (Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University)
Lee, Jee-Sook (Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University)
Noh, Hyun-In (Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University)
Yoon, Da-Rae (Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University)
An, Soo-Min (East-west medicine department, Graduate school of east-west medical science, Kyung-hee University)
Lew, Jae-Hwan (East-west medicine department, Graduate school of east-west medical science, Kyung-hee University)
Publication Information
The Journal of Korean Medicine / v.32, no.4, 2011 , pp. 37-47 More about this Journal
Abstract
Objectives: This study investigated the effects of Choweseuncheung-tang (CWSCT, Tiaoweishengqing-tang) on body weight, serum lipid level, serum insulin level and serum leptin level in high-fat-diet-induced obese mice. Methods: Four-week-old male C57BL/6 mice were randomly divided into three groups (7 mice in each group), including a normal group, control group, and CWSCT group. The normal group was fed a general diet, but the other groups were fed a high fat diet. The CWSCT group was administered CWSCT for 4 weeks. Animals were weighted weekly and blood lipids, insulin and leptin levels were measured after 4 weeks. Results: The results were as follows. 1. In the CWSCT group, compared with the control, body weight gain was significantly inhibited. 2. In the CWSCT group, compared with the control, the level of HDL cholesterol in serum increased significantly. 3. In the CWSCT group, compared with the control, the ratio of total cholesterol to HDL cholesterol decreased significantly. 4. In the CWSCT group, compared with the control, the elevation of serum leptin level was significantly inhibited. Conclusions: Choweseuncheung-tang treatment has inhibitory effects on obesity and hyperlipidemia in high-fat-dietinduced obese mice.
Keywords
Choweseuncheung-tang; obesity; hyperlipidemia;
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