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http://dx.doi.org/10.4217/OPR.2011.33.2.185

Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum  

Lee, Jung-Im (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
Kong, Chang-Suk (Department of Food and Nutrition, College of Medical and Life Sciences Silla University)
Jung, Myoung-Eun (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
Hong, Joo-Wan (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
Noh, Il (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
Seo, Young-Wan (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
Publication Information
Ocean and Polar Research / v.33, no.2, 2011 , pp. 185-191 More about this Journal
Abstract
Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic $ONOO^-$, and $ONOO^-$ derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic $ONOO^-$ were 56, 37, 56, and 54%, respectively, at a concentration of 1 ${\mu}M$. On the other hand, the inbihition ratios of compounds 1-4 against $ONOO^-$ generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.
Keywords
Limonium tetragonum; scavenging effect; reactive nitrogen species (RNS);
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