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http://dx.doi.org/10.22246/jikm.2022.43.1.22

A Study on the Blood Sugar Improvement Effect and Safety of Galgunhwangryunhwanggum-tang for Type 2 Diabetes without Complications: A Systemic Review and Meta-Analysis  

Shin, Jae-ik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
Baek, Ji-soo (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
Cho, Chung-sik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
Publication Information
The Journal of Internal Korean Medicine / v.43, no.1, 2022 , pp. 22-40 More about this Journal
Abstract
Objectives: The purpose of this study is to assess the antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications by analyzing related research. Methods: For a systematic review and meta-analysis, we searched for the antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications in 10 databases up to September 2021. Only randomized controlled trials were chosen. Results: In the treatment effectiveness analysis and meta-analysis, Galgunhwangryunhwanggum-tang had significant improvement effects on fasting plasma glucose level, 2-hour postprandial glucose level, glycated hemoglobin, fasting insulin, and homeostasis model assessment for insulin resistance compared to the control group when treated in parallel with oral glycemic drugs. Conclusion: Galgunhwangryunhwanggum-tang is effective in improving blood sugar and insulin resistance in type 2 diabetes patients without complications and can especially be considered in parallel treatment with oral hypoglycemic drugs. A large-scale randomized controlled clinical trial is required to complement the limitations presented in this study in the future.
Keywords
Galgunhwangryunhwanggum-tang; antidiabetic effect and safety; type 2 diabetes without complications; systematic review; meta-analysis;
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