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http://dx.doi.org/10.22246/jikm.2021.42.5.820

A Case Report on ROS1-positive Recurrent Non-small-cell Lung Cancer Treated with Crizotinib and Korean Medicine  

Jang, Kwon-jun (Jangdeuk Korean Medicine Hospital)
Yang, Jung-min (Jangdeuk Korean Medicine Hospital)
Lee, Ji-yoon (Jangdeuk Korean Medicine Hospital)
Ko, Eun-bi (Jangdeuk Korean Medicine Hospital)
Moon, Hyang-ran (Jangdeuk Korean Medicine Hospital)
Yoon, Min-ji (Jangdeuk Korean Medicine Hospital)
Jo, On-you (Jangdeuk Korean Medicine Hospital)
Jeong, Seong-heon (Jangdeuk Korean Medicine Hospital)
Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Shin, Kwang-soon (Jangdeuk Korean Medicine Hospital)
Hwang, Woo-seok (Jangdeuk Korean Medicine Hospital)
Publication Information
The Journal of Internal Korean Medicine / v.42, no.5, 2021 , pp. 820-832 More about this Journal
Abstract
Objectives: This study examined the case of a patient with ROS1-positive recurrent non-small-cell lung cancer treated with crizotinib and traditional Korean medicine. Methods: The patient was treated with crizotinib from January 20 2021 to May 22 2021, together with Haedogyangpye-tang and Haengso-tang. The tumor size was measured using computed tomography (CT), and adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. Results: After four months of combined treatment, the sizes of the lymph nodes in the porta hepatis, hepatoduodenal, retrocrural, aortocaval, and para-aortic areas had decreased, and no lymph nodes larger than 1 cm in diameter were observed. The side effects of chemotherapy also improved. Conclusions: This case study suggests that traditional Korean medicine may alleviate the side effects of chemotherapy, improve quality of life, and complement chemotherapy itself.
Keywords
ROS1; non-small cell lung cancer; crizotinib; traditional Korean medicine;
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