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http://dx.doi.org/10.22246/jikm.2021.42.4.455

Herbal Medicine for the Treatment of Viral Hepatitis B and C: A Systematic Review of Randomized Controlled Trials  

Kim, Seung-mo (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Lee, Yu-ri (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Cho, Na-kyung (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Choi, Hong-sik (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Kim, Kyung-soon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Publication Information
The Journal of Internal Korean Medicine / v.42, no.4, 2021 , pp. 455-474 More about this Journal
Abstract
The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that applied herbal medicine to treat viral hepatitis B and C in order to determine the therapeutic efficacy of herbal medicine. EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, and Oasis databases were searched to identify RCTs. The selected studies were assessed by the Cochrane group's risk of bias tool. A total of 15 RCTs were selected, and the hepatitis B virus (HBV) DNA reduction was significantly higher in patients treated with herbal medicine combined with Western medicine than in patients treated with herbal medicine. Herbal medicine combined with Western medicine was also superior to Western medicine alone in achieving hepatitis B e-antigen (HBeAg) and alanine aminotransferase [ALT] reduction. Only herbal medicine alone was not superior to Western medicine treatments in achieving HBV DNA, HBeAg, and ALT reduction.
Keywords
herbal medicine; viral hepatitis; systematic review; meta-analysis;
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