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http://dx.doi.org/10.22246/jikm.2020.41.6.1066

The Effect of Herbal Medicine on Blood Glucose in Type 2 Diabetes Patients: A Retrospective Study  

Yu, Chang-hwan (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Kang, Sung-woo (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Hong, Sung-eun (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Kwan-il (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Jung, Hee-jae (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Lee, Beom-joon (Division of Allergy, Immune and Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.41, no.6, 2020 , pp. 1066-1077 More about this Journal
Abstract
Objective: This study was conducted to evaluate the effect of herbal medicine on blood glucose in diabetic patients. Methods: The subjects were patients with diabetes mellitus (DM) who had been admitted to Kyung Hee University Korean Medicine Hospital for more than 8 weeks for a primary diagnosis other than DM and who had taken herbal medicine for more than 8 weeks from January 2010 to February 2020. The medical records were analyzed retrospectively to confirm the characteristics of the subjects, and examination results included hemoglobin A1c (HbA1c), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine. Changes in HbA1c before and after taking herbal medicine and changes according to subgroups were analyzed. Results: A total of 149 subjects with type 2 DM were selected as participants. After taking the herbal medicine, the HbA1c value was significantly decreased, and the statistical significance was maintained even when the effect of controlling antidiabetic agents was excluded. The decrease in HbA1c was higher in the poor glycemic control group. Liver and kidney functions did not show any significant changes after taking the herbal medicine. Conclusions: Administration of herbal medicine for a long period of 8 weeks or longer did not increase HbA1c in patients with DM complicated by other various diseases.
Keywords
diabetes mellitus (DM); herbal medicine; blood glucose; Hemoglobin A1c (HbA1c);
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1 Saxena A, Anderson CS, Wang X, Sato S, Arima H, Chan E, et al. Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study. Stroke 2016;47(3):682-8.   DOI
2 Mellitus AGSEP on C of OA with D, Moreno G, Mangione CM, Kimbro L, Vaisberg E. Guidelines abstracted from the American Geriatrics Society Guidelines for Improving the Care of Older Adults with Diabetes Mellitus: 2013 update. J Am Geriatr Soc 2013;61(11):2020-6.   DOI
3 Noh J. The Diabetes Epidemic in Korea. Endocrinol Metab (Seoul, Korea) 2016;31(3):349-53.   DOI
4 Ministry of Health and Welfare Korea Centers for Disease Control and Prevention. Korea Health Statistics 2018: Korea National Health and Nutrition Examination Survey (KNHANES VII-3). Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention; 2019. https://knhanes.cdc.go.kr/knhanes/sub04/sub04_03.do
5 Shin H, Moon B, Kim D, Shin S, Han M, Choi J, et al. The Effect of General Herb Medications on The Blood Glucose Level of 26 Diabetes Mellitus Patients. J Soc Stroke Korean Med 2002;3(1):27-33.
6 National Institute for Korean Medicine Development. Basic Report on the Survey of Korean Medicine in 2017. National Institute for Korean Medicine Development. Published 2018. Accessed September 25, 2020. http://www.koms.or.kr/board/researchReport/view.do?post_no=45&menu_no=21
7 Tian J, Lian F, Yu X, Cui Y, Zhao T, Cao Y, et al. The Efficacy and Safety of Chinese Herbal Decoction in Type 2 Diabetes: A 5-Year Retrospective Study. Evidence-Based Complement Altern Med 2016;2016:5473015.
8 Jin D, Tian J, Bao Q, Zhang H, Ding Q, Lian F, et al. Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complement Altern Med 2019;2019:1825750.
9 Cha J, Kim W. Clinical Effect of Korean Medical Treatments on Stroke in a Public Health Center. J Int Korean Med 2020;41(2):111-21.   DOI
10 Chung EJ, Kim MJ, Seo YT, Ha BW, Yim CM, Ham YH. Limb hematoma and acute compartment syndrome following acupuncture in a type 2 diabetic. Korean J Med 2008;75(3):862-5.
11 Kim MK, Ko SH, Kim BY, Kang ES, Noh J, Kim SK, et al. 2019 Clinical Practice Guidelines for Type 2 Diabetes Mellitus in Korea. Diabetes Metab J 2019;43(4):398-406.   DOI
12 Ahn CW. Prescribing Guidelines for type 2 diabetes mellitus in the elderly. Korean J Clin Geriatr 2005;6(3):347-51.
13 Peel R, Hure A, Wiggers J, McEvoy M, Holliday E, Searles A, et al. Zinc in Preventing the Progression of pre-Diabetes (ZIPPeD Study) - study protocol for a randomised placebo-controlled trial in Australia. Trials 2019;20(1):219.   DOI
14 Kang BK, An SH, Kim JY, Gwak HS. Comparisons of Efficacy between Dapagliflozin and Sitagliptin in Combination with Metformin in Type 2 Diabetes Mellitus Patients. Korean J Clin Pharm 2017;27(2):99-104.   DOI
15 Benoit SR, Fleming R, Philis-Tsimikas A, Ji M. Predictors of glycemic control among patients with Type 2 diabetes: A longitudinal study. BMC Public Health 2005;5(1):36.   DOI
16 Khattab M, Khader YS, Al-Khawaldeh A, Ajlouni K. Factors associated with poor glycemic control among patients with Type 2 diabetes. J Diabetes Complications 2010;24(2):84-9.   DOI
17 Seo MH, Lee WY, Kim SS, Kang JH, Kang JH, Kim KK, et al. 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea. J Obes Metab Syndr 2019;28(1):40-5.   DOI
18 Committee for the Korean Guidelines for the Management of Dyslipidemia. 2015 Korean Guidelines for the Management of Dyslipidemia: Executive Summary (English Translation). Korean Circ J 2016;46(3):275-306.   DOI
19 Duarte CG, Preuss HG. Assessment of renal function-glomerular and tubular. Clin Lab Med 1993;13(1):33-52.   DOI
20 Yun YJ, Shin BC, Shin WJ, Jang IS. Suggestion of Herbal Medicine-Induced Liver Injury Investigation Forms for Improving the Research Quality of Herbal Safety. J Int Korean Med 2009;30(1):181-90.
21 Franz MJ, Powers MA, Leontos C, Holzmeister LA, Kulkarni K, Monk A, et al. The Evidence for Medical Nutrition Therapy for Type 1 and Type 2 Diabetes in Adults. J Am Diet Assoc 2010;110(12):1852-89.   DOI
22 Yi D, Kang YH. Drug-Induced Diabetes Mellitus. J Korean Diabetes 2017;18(3):160-8.   DOI
23 European Medicines Agency. Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. European Medicines Agency 2018. Published 2018. Accessed September 24, 2020. https://www.ema.europa.eu/en/clinical-investigation-medicinal-products-treatment-prevention-diabetesmellitus
24 Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes Metab Syndr Obes 2014;7:587-91.
25 Hirst JA, Stevens RJ, Farmer AJ. Changes in HbA1c level over a 12-week follow-up in patients with type 2 diabetes following a medication change. PLoS One 2014;9(3):e92458-e92458.   DOI
26 Vijayaraghavan K. Treatment of dyslipidemia in patients with type 2 diabetes. Lipids Health Dis 2010;9(1):144.   DOI
27 El-Kebbi IM, Cook CB, Ziemer DC, Miller CD, Gallina DL, Phillips LS. Association of younger age with poor glycemic control and obesity in urban african americans with type 2 diabetes. Arch Intern Med 2003;163(1):69-75.   DOI
28 Iwasaki T, Hirose A, Azuma T, Ohashi T, Watanabe K, Obora A, et al. Association between eating behavior and poor glycemic control in Japanese adults. Sci Rep 2019;9(1):3418.   DOI
29 Wysham C, Shubrook J. Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications. Postgrad Med 2020;132(8):676-86.   DOI
30 Parker AR, Byham-Gray L, Denmark R, Winkle PJ. The Effect of Medical Nutrition Therapy by a Registered Dietitian Nutritionist in Patients with Prediabetes Participating in a Randomized Controlled Clinical Research Trial. J Acad Nutr Diet 2014;114(11):1739-48.   DOI
31 Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke. Stroke 2019;50(12):e344-e418.
32 Wu TY, Putaala J, Sharma G, Strbian D, Tatlisumak T, Davis SM, et al. Persistent Hyperglycemia Is Associated With Increased Mortality After Intracerebral Hemorrhage. J Am Heart Assoc 2017;6(8):e005760.   DOI