Browse > Article
http://dx.doi.org/10.22246/jikm.2020.41.3.362

A Study Trend for the Effects of Banxia-xiexin-tang Decoction (Banhasasim-tang) on Gastroesophageal Reflux Disease (GERD) in Chinese and Korean Databases over the Last Ten Years  

Jung, Yu-jin (Dept. of Korean Internal Medicine, Dong-Eui University Hospital at Busan)
Kim, Yoon-jung (Dept. of Korean Internal Medicine, Dong-Eui University Hospital at Busan)
Hong, Sang-hoon (Dept. of Korean Internal Medicine, Dong-Eui University Hospital at Busan)
Publication Information
The Journal of Internal Korean Medicine / v.41, no.3, 2020 , pp. 362-413 More about this Journal
Abstract
Objectives: The purpose of this research is to examine the recent clinical research trends on the efficiency of traditional herb medicine (THM) on gastroesophageal reflux disease (GERD), and to provide clinical evidence of herbal medicine, Banhasasin-tang or Banxiexin decoction by using a systemic review and meta-analysis of randomized trials (RCTs). Methods: In this study, randomized controlled trials (RCTs) were included that verified effects of traditional herbal medicine (THM), including a Banxia-xiexin-tang decoction, as a treatment for GERD. A study of the literature in Chinese and Korean databases was performed for papers published from January 1, 2010, to January 1, 2020. The selected literature was assessed by Cochrane's risk of bias (RoB). Results: A total of 90 RCTs met the inclusion criteria. Except for four RCT studies, all studies identified the effect of a Banxia-xiexin-tang decoction in the treatment of GERD. The effectiveness of treatment was significantly higher in the intervention group than in the control group, as shown through various evaluation indicators, including the reflux disease diagnostic questionnaire (RDQ). Adverse effects were reported in 22 articles (24.44%). Conclusions: Treatment with Banhasasin-tang, or a Banxia-xiexin-tang decoction, was found to be effective in treating GERD. However, due to the low quality of available studies, the significance of this conclusion is somewhat limited. This study could serve as a foundation for further clinical studies on the development of diagnosis and treatment methods for GERD based on Korean medicine.
Keywords
gastroesophageal reflux disease; GERD; Banxiexin decoction; Banhasasin-tang; traditional herb medicine; THM;
Citations & Related Records
Times Cited By KSCI : 20  (Citation Analysis)
연도 인용수 순위
1 Chen X. Clinical curative effec of the BanxiXiexin decoction on treating 58 cases of GERD. Clinical Journal of Chinese Medicine 2013;5(15):32-3.
2 Cao WY. 32 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. Chin J Interg Trad West Med Dig 2013;21(3):155-6.
3 Wang YP, Yang H. Therapeutic effect of traditional Chinese medicine on gastroesophageal reflux disease. Chinese Journal of Trauma and Disability Medicine 2013;13(21):9-10.
4 Yang Q, Li JX, Li XH. Influences of modified BanxiaXiexin Tang on symptoms and quality of life in patients with non-erosive reflux disease. Journal of Beijing University of Traditional Chinese Medicine 2013;36(4):280-4.   DOI
5 Hou JX. 48 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. Henan Tradit Chin Med 2012;32(8):971-2.
6 Shen YL. BanxiaXiexin Tang in Treating Reflux Esophagitis Curative Effect Observation. Journal of Liaoning University of TCM 2012;14(8):180-1.
7 Chen XJ. Observation of BanxiaXiexin Decoction on gastroesophageal reflux disease. Strait Pharm J 2012;24(11):133-4.
8 Yang Q, Li JX, Li XG. Therapeutic effect of BanxiaXiexin Decoction on non-erosive reflux disease. Jilin Journal of Traditional Chinese Medicine 2012;32(9):907-10.
9 Shi YP. Clinical Observation of Banxiaxiexin Decoction in Treatment of Bile Reflux Esophagitis. Chinese Journal of Medicinal Guide 2012;15(5):823-4.
10 Jin HB. 36 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. Chinese community doctors (Medical Major) 2012;14(333):182-3.
11 Ye F. 56 cases of gastroesophageal reflux disease treated with BanxiaXiexin Decoction. Chinese Medicine Modern Distance Education of China 2011;9(3):92-3.
12 Wang Y, Wei W. Clinical Observation of Reflux Esophagitis Treated with Modified BanxiaXiexin Decoction and Rabeprazole. World Journal of Integrated Traditional and Western Medicine 2013;8(2):200-2.
13 Huai XX, Gao CL. BanxiaXiexin Decoction Combined with rabeprazole in the treatment of reflux esophagitis. Guangming Tradit Chin Med (CJGMCM) 2013;28(6):1217-8.
14 Tan ZX. Clinical Efficacy Observation of BanxiaXiexin Decoction for Treating Gastroesophageal Reflux Disease on 43 Cases. China Pharm 2013;22(24):90-2.
15 Bai SC. Treatment of reflux esophagitis with combination of traditional Chinese and Western Medicine. Chinese community doctors (Medical Major) 2012;14(311):211.
16 Han XL. Clinical observation on the treatment of reflux esophagitis with the combination of traditional Chinese and Western Medicine. The Medical Forum 2011;15(8):758.
17 Cheng ZH. Therapeutic effect and safety analysis of BanxiaXiexin Decoction in the treatment of reflux esophagitis. China Modern Doctor 2011;19(14):65-6.
18 Gong SQ. Clinical observation on 60 cases of Reflux Esophagitis Treated with the combination of traditional Chinese and Western Medicine. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine 2010;10(5):51-2.   DOI
19 Cao CN, Zhang BP, Zhao XY. Clinical Efficacy of BanxiaXiexin Decoction and Its Effects on Anxiety and Sleep Quality of Patients with Reflux Esophagitis. Journal of Guangzhou University of Traditional Chinese Medicine 2018;35(5):780-4.
20 Sun XL. The curative effect observation of BanxiaXiexin Decoction Combined with the method of reducing the pain, opening the pain and reducing the pain in the treatment of gastroesophageal reflux disease. Guide of China Medicine 2019;17(25):167.
21 Tong SM. Clinical study on the treatment of reflux esophagitis with xinkaikujiang method. Asia-Pacific Traditonal Medicine 2017;13(14):113-4.
22 Wang SQ. Literature and clinical application of Hefa in the treatment of reflux esophagitis. Dept. of Clinical Chinese Medicine Graduate School, Beijing University of Chinese medicine 2015.
23 Sun XH, Niu R, Yang JQ, Shi HX, Zhang Y, Liu T, et al. Clinical observation on 60 cases of gastroesophageal reflux disease treated by xinkaikujiang method. Global Chinese Medicine 2013;6(S1):76-7.
24 Kim SY, Park JE, Seo HJ, Lee YJ, Jang HB, Son HJ, et al. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. Seoul: National Evidence-based Healthcare Collaborating Agency; 2011, p. 64.
25 Wiggins JPT, Altman DG, Sterne JAC, Chapter S: assising risk of bias in included studies. In: Higgines JPT, Green S. Chochrane handbook for systematic rivies of interventions version 5.1.0 [updated March 2011]. The cochrane collaboration. 2011. Availabe from: http://handbook.cochrane.org/
26 Lee JY. Meta-analysis. Korean Journal of Endocrinology 2008;23(6):361-78.   DOI
27 Li YF. 44 cases of gastroesophageal reflux disease treated with BanxiaXiexin Decoction. J Pract Tradit Chin Med 2011;27(11):747.
28 Cao CN. Clinical effect of cold and heat regulating therapy on reflux esophagitis and intervention on patients' psychological state. Dept. of Clinical Chinese Medicine Graduate School, Guanzhou University of Chinese Medicine 2016.
29 Sun P, Tian XD, Li YL. Study on the Effects of BanxiaXiexin Tang on Esophageal Dynamics in Gastroesophageal Reflux Disease Patients. Western Journal of Traditional Chinese Medicine 2019;11(32):98-101.
30 Huang DH, Wu YN, Chen YB, Cao J. Clinical observation on the treatment of 41 cases of gastroesophageal reflux disease of cold and heat type by Decoction of Pinellia and Xiexin. Traditional Chinese Medicine Journal 2018;17(3):57-9.
31 Tang YQ. Clinical effective observation on treating 65 cases of gastroesophageal reflux disease with BanxiaXiexin decoction. Clinical Journal of Chinese Medicine (CJCM) 2011;3(13):17-8.
32 Duan XF. Therapeutic effect of BanxiaXiexin Decoction on 72 cases of gastroesophageal reflux disease. Chin J of Clinical Rational Drug Use 2011;4(12B):69-70.
33 Xu YJ. Clinical observation on 35 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. Inner Mongolia J Tradit Chin Med 2010;5:13.
34 Mo X. Clinical observation on the treatment of reflux esophagitis with BanxiaXiexin Decoction. Chinese Community Doctors (Medical Major) 2010;12(26):133.
35 Liu HY, Zhao ZL, Yang LG. Clinical observation of BanxiaXiexin Decoction in the treatment of reflux esophagitis. Chin F Diffic and Compl Cas 2010;9(10):764-5.
36 Liu LQ. 60 cases of gastroesophageal reflux disease treated with Xintang. Inner Mongolia J Tradit Chin Med 2010;4:9.
37 Lu Wei, Liu XW, Li Y. BanxiaXiexin Decoction in the treatment of reflux esophagitis. Chinese Medicine Modern Distance Education of China 2010;3(13):96-7.
38 Choi YJ, Jung TY, Lim SC. Inhibitory Effecs of Naegwan-acupuncture (PC6) on acute reflux esophagitis Rat. Journal of Korean Acupunbture & Moxibustion Medicine Society 2013;30(2):31-41.
39 손여원. 위식도역류질환 치료제 임상시험 가이드라인. 식품 의약품 안전평가원. 의약품심사부 소화계약품과 2015.
40 Kang SY. A review on clinical studies of acupuncture and moxibustion therapy for gastroesophageal reflux disease in China by searching CAJ. Korean J of Acupucture 2015;12(1):1-12.
41 전국 한의과대학 비계내과학교실. 비계내과학. 서울: 군자출판사; 2008.
42 Jung HK, Hong SJ, Jo YJ, Jeon SW, Cho YK, Lee KJ, et al. Updated guidelines 2012 for gastroesophageal reflux disease. Korean J Gastroenterol 2012;60(4):195-218.   DOI
43 Li Y. Analysis of the therapeutic effect of BanxiaXiexin Decoction on reflux esophagitis. Contemporary Medical Symposium 2018;16(4):211-2.
44 Tang RZ, Fu XY, Liang SQ, Chen FL, Li X, Liang WG. Treatment of Reflux Esophagitis with BanxiaXiexin Decoction. Modern Hospitals 2018;18(6):910-2.
45 Chen JM, Feng HS, Chen CX. Analysis of Cost-effectiveness of Banxiaxiexin Decoction in Treating Ｒeflux Esophagitis and Evaluation of Adverse Drug Adverse Ｒeaction. Pharmacy Today 2018;28(4):273-5.
46 Yang H, Liang XM. To analyze the clinical effect of BanxiaXiexin Decoction in the treatment of reflux esophagitis and the improvement of symptom score. Journal of Clinical Medical 2018;5(84):60.
47 Liu Qian. The Clinical Value of Modified BanxiaXiexin Decoction in Treating Reflux Esophagitis. World composite medicine 2018;4(2):7-9.
48 Li D, Gu ZJ. Therapeutic effect of BanxiaXiexin Decoction on gastroesophageal reflux disease. Shaanxi Journal of Traditional Chinese Medicine 2017;38(7):903-4.
49 Gu HT. Clinical analysis of BanxiaXiexin Decoction on 58 cases of gastroesophageal reflux disease. Guide of China Medicine 2017;15(29):192-3.
50 Gao WW. BanxiaXiexin Decoction in the treatment of 67 cases of gastroesophageal reflux disease. Journal of Emergency in Traditional Chinese Medicine 2010;19(2):212-3.   DOI
51 Chang YJ. Clinical effect of BanxiaXiexin Decoction on reflux esophagitis. Gansu Science and Technology 2019;35(12):107-8.
52 Wang H. Clinical Study on Treatment of Cold and Heat Miscellaneous Gastroesophageal Reflux Disease with BanxiaXiexin Decoction and Western Medicine. Smart Healthcare 2019;3(5):103-4.   DOI
53 Yun HR, Jung HY, Park HJ, Bae SC. Cost-effectiveness analysis of proton pump inhibitors and ranitidine in the treatment of gastroesophageal reflux disease. Korean J Med 2002;62(5):504-12.
54 Pan S, Lan QQ. Clinical research on the effect of Cold and Warming Method treating on Refluz Esophagitis and the psychological state and sleep qulaity of Reflux esophagitis patients. Liaoning Journal of Traditional Chinese Medicine 2011;38(3):479-80.
55 Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101(8):1900-20.   DOI
56 Jung H, Hong SJ, Jo YJ, Jeon SW, Cho YK, Lee KJ, et al. Updated guidelines 2012 for gastroesophageal reflux disease. Korean J Gastroenterol 2012;60(4):195-218.   DOI
57 Hunt R, Armstrong D, Katelaris P, Afihene M, Bane A, Bhatia S, et al. World gastroenterology organisation global guidelines: GERD global perspective on gastroesophageal reflux disease. J Clin Gastroenterol 2017;51(6):467-78.   DOI
58 Park CH, Lee SK. Gastroesophageal Reflux Disease. Korean J Gastroenterol 2019;73(2):70-6.   DOI
59 Odsuka K. Explanation I Sumptomatical Practice of Kampo-Medicine. Wonju: Euibanseolim; 2013, p. 356-555.
60 Fitoshi S. Pathophysiology로 이해하는 내과학 6권. 서울: 도서출판 정담; 2002, p. 54-5.
61 Moon JJ, Ahn GS, Kim SH, Park JH, Kim DH, Choi DY, et al. ShangHanLunJengHae. Seoul: Publication HanEuiMunHwaSa; 2010, p. 317-9.
62 Lee SI. ShinGobangchancha. Seoul: Publication Gunja; 2012, p. 267-8.
63 한의과대학방제학교수 共編著. 方劑學. 서울: 대성문화사; 1993, p. 112-3, 116-7.
64 Naito T, Itoh H, Uasunaga F, Takeyama M. Hange-shashin-to raises levls of smatostatin, motilin, and gastrin in the plasma of healthy subjects. Biol Pharm Bull 2002;25(3):327-31.   DOI
65 Jang MW. Lim SW. Experimental study for Effect of Banhasasim-tang on Mice with Reflux esophagitis. Korean J Orient Int MED 2013;34(4):362-74.
66 Feng YC. Therapeutic effect of BanxiaXiexin Decoction on 32 cases of reflux esophagitis. Inner Mongolia J Tradit Chin Med 2016.
67 Huang FZ. Treatment of 64 cases of reflux esophagitis with qigesan and Banxiaxiexin Decoction. Guangming Tradit Chin Med 2016;31(23):3461-2.
68 He H, Han XF. Clinical observation on BanxiaXiexin Decoction in the treatment of non-erosive reflux disease. Zhejiang J Tradit Chin Med 2016;51(1):27-8.
69 Chen J. Effect of BanxiaXiexin Decoction in the Treatment of Reflux Esophagitis. China health standard management 2016;7(36):120-3.
70 顔正華. 中藥學. 中國: 人民術生出版社; 1991, p. 134, 178, 594, 721, 721.
71 黃泰康. 常用中藥成分與藥理手冊. 中國: 中國醫藥科技出版社; 1994, p. 178.
72 焦樹德. 用藥心得十講. 서울: 醫聖堂; 2001, p. 94.
73 Lee JE, Park JH, Cho HS, Kim JC, Oh SW, Lee SH, et al. A Case Report of Gastroesophageal Reflux Disease (GERD) with Hiatal Hernia. Korean J Orient Int Med 2005;26(1):244-51.
74 Kim HJ, Lim SY, Kwak MA, Kim DJ, Byun JS. Effects of Yijintang-gamibang on Reflux Esophagitis Induced by Pylorus and Forestomach Ligation in Rat. Korean J Orient Int Med 2010;31(1):128-41.
75 Hwang GY, Kim DJ, Byun JS. Effects of Yijintang-gamibang Extracts on Reflux Esophagitis. Korean J Oriental Psysiology & Pathology 2006;23(4):1073-9.
76 Choi BH, Kim DJ, Byun JS. Suppressive Effects of Yijintang-gamibang on Reflux Esophagitis. Korean J Oriental Psysiology & Pathology 2010;31(5):64-81.
77 Park K, Kwak MA, Kim DJ, Byun JS. Protective Effects of Yijin-tang-gamibang Aqueous Extracts on Reflux Esophagitis Mediated by Antioxidant Defense Systems. Korean J Oriental Psysiology & Pathology 2010;24(3):416-25.
78 Lee ST, Kwak MA. Effects of Individual Herbal Components of Yijintang-gamibang in the Rat Reflux Esophagitis. Korean J Orient Int Med 2013;34(2):165-77.
79 Lee YJ, Park JH, Rho SS. Effects on Rats with Reflux Esophagitis Treated with LoniceraeFlos Extract. Korean J Orient Int Med 2010;24(6):970-5.
80 Sun Q. Application and effect of BanxiaXiexin Decoction in the treatment of reflux esophagitis. Health way 2016;15(12):2229-30.
81 Lin L. Clinical observation on 32 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. Heilongjiang Journal of Traditional Chinese Medicine 2016;3:19.
82 Wang GQ. Efficacy Observation of Banxiaxiexin Soup Modified Treatment of Reflux Esophagitis. China & Foreign Medical Treatment 2016;1:150-1.
83 Wang HT. Effect of BanxiaXiexin Decoction on gastroesophageal reflux. The Medical Forum 2016;20(12):1670-1.
84 Wang JP, Zhou WT, Gu RY, Song GH, Liu HM. Clinical observation of BanxiaXiexin Decoction in the treatment of gastroesophageal reflux disease. Journal of Emergency in Traditional Chinese Medicine 2016;25(9):1828-9.
85 Lim MH. Clinical effect of BanxiaXiexin Decoction on gastroesophageal reflux disease. Journal of North Pharmacy 2016;13(10):93-4.
86 Wang ZB. Analysis of the therapeutic effect of BanxiaXiexin Decoction Combined with cisapride on reflux esophagitis. Digest World Latest Med Inf 2018;18(53):175-6.
87 Lu J, Liang CH. Effect of BanxiaXiexin Decoction Combined with Jianfang and Rabeprazole on reflux esophagitis. Contemporary Medical Symposium 2019;17(6):182-3.
88 Zhao XY. Effect of BanxiaXiexin Decoction Combined with omeprazole in the treatment of febrile reflux esophagitis. Family medicine 2018;12:381-2.
89 Zhang XC. Clinical Observation on BanxiaXiexin Decoction Combined with Omeprazole in the Treatment of Intermingled Heat and Cold Reflux Esophagitis. Guangming Tradit Chin Med (CJGMCM) 2018;33(18):2746-7.
90 Wu YB. Observation on the curative effect of integrated traditional Chinese and Western Medicine on gastroesophageal reflux disease. J Pract Tradit Chin Med 2018;34(4):467-8.
91 Lee JY, Seo BI, Roh SS. Improving effect of ArtemisiaeCapillarisHerba extract in reflux esophagitis rats. Kor J Herbol 2016;31(6):37-44.   DOI
92 Kim DJ, Rho SS. Effect on Acute reflux Esophagitis by Evodiae Fructus Aquous Extract Kor J Herbol 2012;27(1):51-8.   DOI
93 Lee JA, Park HJ, Kim SH, Kim MJ, Kim KJ, Shin MR, et al. Evaluation of Evodiae Fructus Extract on the Chronic Acid Reflux Esophagitis in Rats. Kor J Herbol 2019;34(2):15-23.   DOI
94 Kim SH, Roh SS, Lee JA, Shin MR, Lee AR, Koo JS, et al. Improving Effects on Rats with Chronic Acid Reflux Esophagitis Treated of CoptidisRhizoma Extract. Kor J Herbol 2019;34(1):117-24.   DOI
95 Shim MH, Kim ES, Lee YS. Suppressive Effects of UlmiPumilae Cortex Extracts on the Reflux Esophagitis in Rat. J Physiol & Pathol Korean Med 2016;30(4):257-65.   DOI
96 Wang T. To observe the clinical effect of Banxiaxiexin decoction in treatment of gastroesophageal reflux disease. Inner Mongolia J Tradit Chin Med 2015;12:12-3.
97 Tang L, Liu X, Li XY. Clinical effect of BanxiaXiexin Decoction on gastroesophageal reflux syndrome of phlegm dampness syndrome. Internal medicine 2016;11(5):778-80.
98 Xia BL. Clinical analysis of BanxiaXiexin Decoction in the treatment of reflux esophagitis. Mod Diagn Treat 2015;26(15):3404-5.
99 Dai BH, Zou LM. Clinical effects of the BanxinaXiexin decoction on gastroesophageal reflux disease. Clinical Journal of Chinese Medicine 2015;7(17):117.
100 Shou HC. Efficacy of the BanxiaXiexin decoction on gastroesophageal reflux disease. Clinical Journal of Chinese Medicine 2015;7(22):102-3.
101 Meng FZ, An XL, Xu JC. Clinical observation on treating reflux esophagitis with the BanxiaXiexin decoction plus Rabeprazole. Clinical Journal of Chinese Medicine (CJCM) 2018;7(26):87-8.
102 Sun YF. The Influence of Pinellia Heart-Draining Decoction on Efficacy and the Expressions of Ghrelin and VIP (vasoactineintrestinal peptide) in Patients with Non-erosive Reflux Disease. Henan Tradit Chin Med 2018;38(11):1639-42.
103 Su YF. Therapeutic effect of BanxiaXiexin Decoction on 43 cases of gastroesophageal reflux disease. Journal of Chengde Medical College 2018;35(1):40-2.
104 Liu HD. Clinical observation on 43 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction and Western Medicine. Chinese Journal of Ethnomedicine and Ethnopharmacy 2018;27(3):98-9.
105 Ha J, Kong KH, Jee HC, Beak TH. A Bibliographycal Study on the Relation of the Spleen, Stomach and the Liver. Korean J Orient Int Med 2010;22(4):675-81.
106 Lim TH, Park HS. 2 Case Reports of Gastroesophageal Reflux Disease Diagnosed as SoyanginMangeum. J SasnagConsitut Med 2015;27(2):297-306.
107 Kim YH, Kim SY, Hwang MW. A Case Study of Taeumin Patient with Gastro-esophageal reflux disease (GERD) who Treated Successfully with Yeoldahanso-tang (Reduohanshao-tang). J of SasnagConsitututional Medicine 2011;23(1):132-8.
108 Lee JS. Effect of Banhasasimtang Granule on Gastric Emptying in Rats. Dept. of Clinical Chinese Medicine Graduate School, Kyunghee University 2006.
109 Song CH, Baek TH. A Comparative Study of SepiaeOs, Arcae Concha, Ostreae Concha and Esomeprazole in a Mouse Model of Reflux Esophagitis. J Korean Med 2018;39(2):92-105.   DOI
110 Yoon SH. A Clinical Case Report of Endoscopic Reflux Esophagitis with Gastric Dysmotility Treated with Korean Traditional Medical Therapy. Korean J Orient Int Med 2016;37(4):669-77.   DOI
111 Lee SH, Baik TH. Comparative Study on the Effects of Pinelliaternata, Zingiber officinale and Sobanhatang on Reflux Esophagitis. J Korean Med 2019;40(2):17-34.   DOI
112 Kwon OJ, Lee AR, Roh SS. Improving Effects on Rats with Reflux Esophagitis Treated with Combined Extract of Young persimmon fruit and Citrus peel. Kor J Herbal 2016;31(1):25-31.   DOI
113 Kim KH, Lee JH, Cho CK, Yoo HW, Lee YW. The Literatual Study of Yijin-tang-gamibang Effects on Reflux Esophagitis. Institute of Korean medicine, Daejeon University 2013;22(1):119-28.
114 Li HP. Therapeutic effect of BanxiaXiexin Decoction on gastroesophageal reflux disease. J MED Theor & Orac 2015;28(19):2636-7.
115 Guo FX. Therapeutic effect of BanxiaXiexin Decoction on reflux esophagitis of liver stomach stagnant heat type. Guide of China Medicine 2014;12(32):276-7.
116 Jiang LQ. 30 cases of gastroesophageal reflux disease treated with traditional Chinese Medicine. Chinese Medicine Modern Distance Education of China 2014.
117 Kim MY, Shin YO, Lee JY, Lee AR, Shin SH, Kwon OJ, et al. Improving Effect of a Combined Extract of Rhei Rhizoma and Glycyrrhizae Rhizoma through Anti-oxidative Stress in Reflux Esophagitis rats. Kor J Herbol 2015;30(4):37-44.   DOI
118 Shin MK, Kim ES, Kim TR, Lim HC, Lee YS. Effects of Jwa Kum-Whan on Reflux Esophagitis in Rats. Korean J Orient Int Med 2016;37(3):495-7.
119 Jeon SY, Kim WB, Seok EJ, Song SY, Jeong JG, Lee SI. An analysis of clinical studies on Banha-Sasim-Tang. Herbal Fomula Science 2018;26(3):267-81.
120 Ahn SB, Lee GY, Hwang HH, Jeong MJ, Jang IH, The Effect of Banhasasim-tang in the Treatment of Chemotherapy-induced Symptoms: A systemic Review. J Int Korean Med 2019;40(4):663-74.   DOI
121 Park JW, Ko SJ, Han GJ, Yeo IK, Ryu BH, Kim JS. The effects of banha-sasim-tang on dyspeptic symptoms and gastric motility in cases of functional dyspepsia; a randomized, double-blind, placebo-controlled, and two-center trial. Evid Based Complement Alternat Med 2013;2013:265035.
122 Yoon SH, Ryu BH, Ryu KW, Kim JS. Evaluation for therapeutic effectiveness of Banshwasashim-tang in functional dyspepsia. Korean J Orient Int Med 2003;24(3):329-36.
123 Li JL. Clinical Observation on 113 Cases of Gastroesophageal Reflux Treated with BanxiaXiexin Decoction. Clinical Journal of Chinese Medicine (CJCM) 2014;6(3):109-10.
124 Kang XQ, Kang Z, Liu L. Clinical manifestations of BanxiaXiexin Decoction in the treatment of reflux esophagitis. Guide of China Medicine 2014;12(4):183-4.
125 Chen YX. Clinical evaluation of the efficacy of BanxiaXiexin decoction on 58 cases with gastroesophageal reflux. Clinical Journal of Chinese Medicine 2014;6(12):20-1.
126 Wang JY. Influences of modified BanxiaXiexin Tang on symptoms and quality of life in patients with non-erosive reflux disease. Chinese Journal of Basic Medicine in Traditional Chinese Medicine 2014;20(11):1562-4.
127 Zhou JF. Treating 30 cases of senile reflux esophagitis with the BanxiaXiexin decoction. Clinical Journal of Chinese Medicine (CJCM) 2013;5(17):92-3.
128 Liu ZY. 68 cases of Reflux Esophagitis Treated with BanxiaXiexin Decoction. J Shaanxi Coll Tradit Chin Med 2013;36(3):51.
129 Zhang JW. Clinical effect of BanxiaXiexin Decoction on gastroesophageal reflux disease. Dept. of Clinical Chinese Medicine Graduate School, Beijing University of Chinese medicine 2013.
130 Ye MB. Observation of BanxiaXiexin Decoction on gastroesophageal reflux disease. Journal of Qiqihar University of Medicine 2013;34(5):671-2.
131 Ruan SR. Clinical observation on treating reflux esophagitis with the BanxiaXiexin decoction plus Cisapride. Clinical Journal of Chinese Medicine (CJCM) 2015;7(22):68-9.
132 Zhou SN. The curative effect of BanxiaXiexin Decoction in the treatment of cold and heat mixed reflux esophagitis. Dept. of Clinical Chinese Medicine Graduate School, Liaoning University of Traditional Chinese Medicine 2017.
133 Guo KS, Zhang HY, Li N, Liu YS, Wei LW, Lu YP. Study on the effect of BanxiaXiexin Decoction Combined with proton pump inhibitor in gastroesophageal reflux disease. Modern regimen 2017;5:11.
134 Chen YF. Clinical analysis of BanxiaXiexin Decoction Combined with western medicine in the treatment of reflux esophagitis. Chinese Community Doctors (Medical Major) 2016;3:10.
135 Cao Y. Clinical study of Mosapride combined with BanxiaXiexin Decoction in the treatment of gastroesophageal reflux disease. J Pract Tradit Chin Med 2016;32(1):54-5.
136 Zhang LJ. A clinical study on treating gastroesophageal reflux disease with Mosapride plus the BanxiaXiexin decoction. Clinical Journal of Chinese Medicine 2016;8(11):50-2.
137 Lin QY. Clinical observation of BanxiaXiexin Decoction Combined with western medicine in the treatment of reflux esophagitis. J Sichuan Tradit Chin Med 2015;33(7):109-11.
138 Liu SX. 49 cases of gastroesophageal reflux disease treated with BanxiaXiexin Decoction and Mosapride. Henan Tradit Chin Med 2014;32(12):2411-2.
139 Liu MG. BanXiaXieXinTang in Treating 50 Cases of Reflux Esophagitis. Western Journal of Traditional Chinese Medicine 2014;27(10):98-9.
140 Tan LH. Clinical observation on treating gastroesophageal reflux disease with BanxiaXiexin decoction. Clinical Journal of Chinese Medicine (CJCM) 2014;6(16):103-4.
141 Cho TK, Lee C, Lee HJ, Yim YK. The Anti-emetic Effect of Banhasasim-tang Intravenous Herbal Acupuncture in MTX-induced Rat-Pica Model. J of Korean Med 2017;38(1):34-5.   DOI
142 Park GH, Choi SW, Park SJ, Joo JC, Park HS. Three Case Reports of Peptic Ulcer Patients Treated with Banhasasim-tang. Korean J Oriental Psysiology & Pathology 2012;26(6):940-6.
143 Han IS, Choi JH, Lim SW. A Study on the Defence Effect of Banhasasim-tang for White Rat's Acute Duodenal Injury. J Korean Oreintal Med 2002;23(3):188-9.
144 Lee GK, Cui X, Lim JP. Effect of the Concurrent Administration of Banhasasim-tang with Cimetidine on Gastric Ulcer in Rats. Korean J Oriental Psysiology & Pathology 2012;16(3):572-6.
145 Shin MK, Hwang HJ, Kim SC, Byun JS. Effect of Banhasasim-tang on the Cardiac Toxicity and clinical symptom induced by Doxorubicin. Herbal formula science 2002;10(1):131-42.
146 Hwang HJ, Shin MK, Kwak MA, Lee YH, Byun JS, Kim SC. Effect of Banhasasim-tang on the Hepatic and Splenic Toxicity induced by Doxorubicin. J of Kor Oriental Oncology 2002; 8(1):9-21.
147 Ju WS, Park HJ, Yun BG, Jun SY, Park SD. Effect of Banhasasimtang on carbon tetrachloride induced hepatoxicity in rats. Kor J Herbal 1999;14(2):51-9.
148 Gi SO, Lee SB, So HS, Kim HR, Lee YR, Lee GS, et al. Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Nephrotoxicity in Mouse Model. Korean J Oriental Psysiology & Pathology 2018;32(5):328-32.
149 Choi GY, Sun SH, Kim BW, Lee SJ, Oh HS, Han IS, et al. Literature Review on Syndrome Differentiation and Herbal Medicine of Reflex Esophagitis - Focusing on Chinese Journals. Korean J Orient Med 2011;32(1):75-86.