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http://dx.doi.org/10.22246/jikm.2020.41.3.350

The Therapeutic Efficacy of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis  

Kim, Eun Hye (Dept. of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong)
Yoon, Jee-Hyun (Dept. of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong)
Lee, Jee Young (Dept. of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong)
Yoon, Seong Woo (Dept. of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong)
Publication Information
The Journal of Internal Korean Medicine / v.41, no.3, 2020 , pp. 350-361 More about this Journal
Abstract
Objective: This study aimed to report the therapeutic effect of acupuncture on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The articles were sourced from databases including PubMed, EMBASE, Cochrane Library, CNKI, CiNii, WHO ICTRP, JSOM, KMBASE, KISS, NDSL, and OASIS as of July 2019. The main search keywords were peripheral neuropathy and acupuncture, and only randomized controlled trials using acupuncture for therapeutic purposes were included. Cochrane's risk of bias was used to assess the risk of bias, and the Review Manager 5.3 program was used for meta-analysis. Results: Six studies with a total 394 participants were included. When combined treatment of acupuncture and usual care was compared with usual care alone, quality of life improved more significantly in the combination treatment group (SMD=-2.71, 95% CI: -5.01 to -0.41, P=0.02, I2=97%). The CIPN pain score was lower among the combination treatment group, but not to a significant degree (SMD=-2.55, 95% CI: -5.14 to 0.04, P<0.05, I2=98%). There were no severe side effects in any studies. Conclusion: Acupuncture combined with usual care may be considered to safely relieve CIPN pain and improve quality of life for cancer patients. However, as there are few randomized controlled trials studying the effect of acupuncture on CIPN, further well-designed research is needed.
Keywords
CIPN; acupuncture; chemotherapy; peripheral nervous system diseases; neuropathy; cancer; systematic review; meta-analysis;
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