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http://dx.doi.org/10.22246/jikm.2020.41.1.1

Protective Effect of Corni Fructus Extracts on MIA-induced Animal Model of Osteoarthritis: Effect of Corni Fructus Extracts on OA  

Baek, Kyungmin (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Korean Medicine Hospital of Daegu Haany University)
An, Yu-min (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Korean Medicine Hospital of Daegu Haany University)
Shin, Mi-Rae (Dept. of Herbology, College of Korean Medicine, Daegu Haany University)
Kim, Min Ju (Dept. of Herbology, College of Korean Medicine, Daegu Haany University)
Lee, Jin A (Dept. of Herbology, College of Korean Medicine, Daegu Haany University)
Ro, Seong-Soo (Dept. of Herbology, College of Korean Medicine, Daegu Haany University)
Publication Information
The Journal of Internal Korean Medicine / v.41, no.1, 2020 , pp. 1-13 More about this Journal
Abstract
Objectives: Osteoarthritis (OA) is a chronic and degenerative joint disease characterized by progressive degeneration of articular cartilage. Inflammation is a recognized and important factor of OA progression. The present study was designed to investigate the protective effect of Corni Fructus water extract (CFW) on a monosodium iodoacetate (MIA)-induced rat model of OA. Methods: Osteoarthritis was induced by injection of MIA (50 µL; 80 mg/mL) into the knee joint cavity of rats. After an adaptation period for seven days, the rats were divided into 4 groups (n=8/group): normal, control, indomethacin-treated (5 mg/kg), and CFW-treated (200 mg/kg) groups. The rats were treated orally for 14 days. Pain was evaluated by determining hind paw weight distribution. For biochemical analyses, we measured the changes in reactive oxygen species (ROS) and peroxynitrite (ONOO-) in the knee joint. The presence of anti-oxidant proteins and inflammatory proteins was determined by western blotting. Results: The administration of CFW significantly improved the hind paw weight distribution. The ROS and ONOO- levels of knee joint were significantly decreased in the CFW group. CFW inhibited the production of inflammatory mediators, such as COX-2, and inflammatory cytokines, including IL-6 and IL-1β, via the NF-κB signaling pathway. The expression of anti-oxidant enzymes, such as catalase and GPx-1/2 also increased significantly. Conclusions: The findings indicate that CFW has a therapeutic and protective effect on OA by suppression of inflammation. Therefore, CFW could represent a potential and effective candidate for OA treatment.
Keywords
monosodium iodoacetate; osteoarthritis; Corni Fructus; inflammation; NF-${\kappa}Bp65$;
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Times Cited By KSCI : 9  (Citation Analysis)
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