Browse > Article
http://dx.doi.org/10.22246/jikm.2019.40.6.1318

Management of Blood Glucose in Diabetes Mellitus Using Modified Jawonjihwang-tang: A Retrospective Case Series of 76 Patients  

Jeong, Yong-wook (Jega Medical Clinic of Korean Medicine)
Jeon, Sang-woo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
Lee, Gi-hyang (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
Kang, Su-bin (Dept. of Neuropsychiatry, College of Korean Medicine, Woo-Suk University)
Jeong, Min-jeong (Dept. of Pediatrics, College of Korean Medicine, Woo-Suk University)
Kim, Hong-jun (Dept. of Prescription, College of Korean Medicine, Woo-Suk University)
Jang, In-soo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
Publication Information
The Journal of Internal Korean Medicine / v.40, no.6, 2019 , pp. 1318-1324 More about this Journal
Abstract
Objectives: The purpose of this study was to evaluate the effectiveness of the management of blood glucose in diabetes mellitus using modified Jawonjihwang-tang in a Korean medical clinic, retrospectively. Methods: From 2006 to 2018, 150 patients diagnosed with diabetes who visited a Korean medical clinic were treated with Korean medicine. Then, 81 of them were prescribed Jawonjihwang-tang. Five cases who changed the formula during the procedure were excluded; therefore, 76 cases were finally selected. Their therapeutic effects were evaluated by the variance in glycated hemoglobin (HbA1c). Results: After administration of Jawonjihwang-tang, most patients exhibited a decreased level of HbA1c, and 24 patients had normalized the level of HbA1c. The HbA1c level of all patients decreased from 9.1±2.2 to 7.8±2.2 significantly (p<0.001). Conclusions: It is concluded that Jawonjihwang-tang may control blood glucose in diabetes patients. However, more prospective randomized clinical trials are warranted to verify this conclusion.
Keywords
diabetes mellitus; Jawonjihwang-tang; glycated hemoglobin; herbal medicine; Korean medicine;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Park SH. Study on change of the pattern identification of diabetes mellitus in Chinese traditional medicine recently - search Chinese traditional medical papers from 2003-2010. Journal of physiology &pathology in Korean Medicine 2011;25(2):176-84.
2 Kim YH. Cheongganguigam. Gyeonggi-do: Seongbosa; 2001, p. 339.
3 Mugabo Y, Zhao S, Seifried A, Gezzar S, AlMass A, Zhang D, et al. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic beta-cells and hepatocytes. Proc Natl Acad Sci USA 2016;113(4):430-9.
4 Zhao S, Mugabo Y, Ballentine G, Attane C, Iglesias J, Poursharifi P, et al. Alpha/beta-hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes. Cell Rep 2016;14(12):2872-88.   DOI
5 Ying B, Ruyuan Z, Yimiao T, Rui L, Beibei C, Hao Z, et al. Catalpol in diabetes and its complications: a review of pharmacology, pharmacokinetics, and safety. Molecules 2019;24(18):3302.   DOI
6 Choi KS. Effects of coated liposome from discorea rhizoma extract (DRE) on hypoglycemic, serum insulin, and lipid levels in streptozotocin-induced. Korean J Food & Natr 2013;26(2):310-7.   DOI
7 Kim OK. Antidiabetic and antioxidative effects of corni fructus in streptozotocin-induced diabetic rats. JKOCS 2005;22(2):157-67.
8 Huang YQ, Yang QF, Wang H, Xu YS, Peng W, Jiang YH. Long-term clinical effect of Tangyiping granules on patients with impaired glucose tolerance Chin J Integr Med 2016;22(9):653-9.   DOI
9 Shin HY, Lee JY, Kim JE, Lee SM, Yoon HJ, Kim HR, et al. Cause-of-death statistics in 2016 in the Republic of Korea. J Korean Med Assoc 2018;61(9):573-84.   DOI
10 Korean diabetes association. Diabetes fact sheet in Korea 2018. May 14 2018. http://www.diabetes.or.kr/pro/news/admin.php?category=A&code=admin&number=1546&mode=view.
11 Kim DH, Park SH, Lee JH, Lee HY, Cho MK, Cho JY, et al. Recent research trends in Korean medicine treatment of diabetes mellitus-focusing on domestic articles from 2008 to 2013. J Int Korean Med 2013;34(3):240-55.
12 Gallagher EJ, Le RD, Bloomgarden Z. Review of hemoglobin A(1c) in the management of diabetes. J Diabetes 2009;1(1):9-17.   DOI
13 Diabetes guideline committee. Treatment guideline for diabetes 2019. Seoul: Korean diabetes association;2019, p. 1-86.
14 UKPDS Group. UK prospective diabetes study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients. Metabolism 1990;39(9):905-12.   DOI
15 Park TS, Baek HS, Park JH, General principles for diabetes mellitus management. J Korean Med Assoc 2008;51(9):806-12.   DOI
16 Jeon JY, Kim DJ. Glycemic targets in patients with diabetes. J Korean Med Assoc 2017;60(11):889-92.   DOI
17 Kim SA, Kang HY, Park WS, Ohrr HC, Song JS, Yi SW, et al. Prevalence and management status of diabetes mellitus in Korea. Korean J Med 2005;68(1):10-17.
18 Murata GH, Shah JH, Hoffman RM, Wendel CS, Adam KD, Solvas PA, et al. Intensified blood glucose monitoring improves glycemic control in stable, insulin-treated veterans with type 2 diabetes: the diabetes outcomes in veterans study (DOVES). Diabetes care 2003;26(6):1759-822.   DOI
19 Duckworth WC, Abraira C, Moritz TE, Davis SN, Emanuele N, Goldman S, et al. The duration of diabetes affects the response to intensive glucose control in type 2 subjects: the VA diabetes trial. J Diabetes Complications 2011;25(6):355-61.   DOI
20 Kim GY, Park JB, Kim BW. Short-term Glycemic control and the related factor in association with compliance in diabetic patient. Journal of Preventive Medicine and Public Health 2000;33(3):349-63.
21 Cho NH. Prevalence of diabetes and management status in Korean population. Korean J Med 2005;68(1):1-3.
22 Pu R, Geng XN, Yu F, Liang HG, Shi LW. Liuwei dihuang pills (六味地黄丸) enhance the effect of western medicine in treating type 2 diabetes: a meta-analysis of randomized controlled trials. Chin J Integr Med 2013;19(10):783-874.   DOI
23 Xie W, Zhao Y, Zhang Y. Traditional Chinese medicines in treatment of patients with type 2 diabetes mellitus. Evid Based Complement Alternat Med 2011;2011:726723.
24 Lin L, Ni Q, Pang JL, Wei JP, Su CL, Yan XF. Therapeutic efficacy evaluation by a randomized controlled clinical research on traditional Chinese medical formulas, with herb modification according to syndrome differentiation in the treatment of 200 type 2 diabetic patients. Journal of Medical Research 2013;42(2):102-7.