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http://dx.doi.org/10.22246/jikm.2019.40.6.1026

A Retrospective Study on the Effect of Daeshiho-tang on the Lipid Profile in Patients with Uncontrolled Dyslipidemia by Statins  

Noh, Ji-won (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Jeong, Soo-min (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Kim, Dong-hyun (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Yoo, Jeong-hwa (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Ahn, Young-min (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Ahn, Se-young (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Lee, Byung-cheol (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.40, no.6, 2019 , pp. 1026-1034 More about this Journal
Abstract
Objective: This study was conducted to investigate the lipid-lowering effect and safety of Daeshiho-tang in patients with uncontrolled lipid levels by statins. Methods: We investigated patients who had an abnormal lipid profile even when taking statins and who were administered Daeshiho-tang at Kyung-Hee University Korean Medical Hospital for at least one day between January 2008 and December 2018. Their basal characteristics and examinations were reviewed retrospectively with respect to lipid profile, AST, ALT, GGT, BUN, and creatinine. The lipid profile was composed of total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol. Subgroup analysis was performed on each component of dyslipidemia. Results: Among 20 participants, there were 10 males and 10 females. The mean BMI was 23.52. Eighty five percent of the participants were diagnosed as having cerebral infarction. After the administration of Daeshiho-tang, total cholesterol and LDL cholesterol were significantly reduced, to 41.3 mg/dl and 33.95 mg/dl, respectively. In subgroup analyses, total cholesterol and LDL cholesterol were significantly decreased, to 63 mg/dl and 54.6 mg/dl, respectively. Liver and kidney function showed no significant difference after taking Daeshiho-tang. Conclusions: Daeshiho-tang as a decoction or powder had significant lipid-lowering effects on total cholesterol and LDL cholesterol in patients with dyslipidemia. The lipid-lowering effect on total and LDL cholesterol increased in patients with hypercholesterolemia and hyper-LDL-cholesterolemia, respectively. Based on the minimal changes in the liver and kidney function test, Daeshiho-tang would be safe enough to be used in clinics.
Keywords
Daeshiho-tang; dyslipidemia; total cholesterol; LDL cholesterol; statin;
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Times Cited By KSCI : 10  (Citation Analysis)
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1 보건복지부 질병관리본부. 2016 국민건강통계 I, 국민건강영양조사 제 7기 1차년도(2016). 청주:질병관리본부; 2017.
2 Lee SR, Ock MY, Kim HA. Comparison of Adverse Events between High-intensity and Moderate- to Low-intensity Statin Group. Korean J Clin Pharm 2018;28(4):293-9.   DOI
3 Maningat P, Gordon BR, Breslow JL. How do we improve patient compliance and adherence to long-term statin therapy? Current Atherosclerosis Reports 2013;15(1):291.   DOI
4 이장천, 이은. 시호 추출물이 고지방식이를 급여 한 흰쥐의 혈청지질 및 항산화계에 미치는 영향. 대한한의학방제학회지. 2003;11(1):151-9.
5 Kim KS, Cha MH, Lee SW, Yoon YS. A Study on the Inhibitory Effects of Scutellariae Radix on Fat Accumulation. Korea Journal Oriental Medicine 2003;9(2):45-54.
6 이영종. 대황 전탕액 분획이 고지방식이 투여 흰쥐의 혈중 지질 함량에 미치는 영향. 대한본초학회지. 2000;15(2):1229-765.
7 Yang HK, Kim YS, Bae HS, Cho KH, Shin JE, Kim NJ, et al. Rhei Rhizoma and Chunghyuldan inhibit pancreatic lipase. Natural Product Sciences 2003;9(1):38-43.
8 Lee JM, et el. Effect of Seeds Extract of Paeonia Lactiflora on Antioxidative System and Lipid Peroxidation of Liver in Rats Fed High-Cholesterol Diet. Journal of nutrition and health 2003;36(8):793-800.
9 Kweon TW, Kim YK, Kim KM. Schisandra Fructus Butanol Fraction Reduces Serum Total Cholesterol and Triglyceride Levels in Hyperlipidemic Mice. J Int Korean Med 2018;39(6):1225-43.   DOI
10 Park SH, Sihn EH, Park SJ, Han JH. Ginsenoside Contents and Hypocholesterolemic Effects of a By-Product in Ginseng Radix. Korea J Oriental Physiology & Pathology 2005;19(2):459-65.
11 Park SW, Seo YJ, Choi HJ, Lew JH. Dyslipidemic Effect of Pravastatin and Herbal Medicine in Rats. J Int Korean Med 2017;38(3):327-35.   DOI
12 Kim SH. Statin and the risk of new-onset diabetes mellitus. J Korean Med Assoc 2017;60(11):901-11.   DOI
13 Lee JH, Lim SM, An JJ, Jo HK, Kim YS, Seol IC, et al. The Effects of Ssanggang-tang on Rat with Induced Hyperlipidemi. Korean J Oriental Int Med 2008;29(2):432-42.
14 Kim BC, Park CS, Park CG, Lee EJ. The Experimental Study on the Effects of Dansamyeum on Hyperlipidemia. Korean J Oriental Int Med 2000;21(1):126-34.
15 Jeong SH, Lee KT, Ann HS, Lee JY, Choi JW, Kim DK. Hypolipidemic and Antixidative Effects of Bangpoongtongsungsankamibang on Diet-Induced Obesity Rats. Korean Journal of Pharmacognosy 2006;37(3):190-5.
16 Kang SY, Kwon HS, Keum HS, Kang SJ, Park CS, Park CG, et al. The Experimental Study on the Effect of Chungsanggyuntong-tang on Hyperlipidemia. Korean J Oriental Int Med 2000;21(3):409-16.
17 Kim MN, Kim HK, Ahn YK, Park HJ, Jeong MH, Cho JG, et al. Comparing high-intensity versus low-to moderate-intensity statin therapy in Korean patients with acute myocardial infarction. J Lipid Atheroscler 2014;3(2):97-104.   DOI
18 Jones PH, Nair R, Thakker KM. Prevalence of dyslipidemia and lipid goal attainment in statin-treated subjects from 3 data sources; a retrospective analysis. JAHA 2012;1(6):e001800.
19 蔡仁植. 傷寒論譯詮. 서울: 高文社; 1995, p. 86, 108, 118.
20 Hee Jung, JC Kang. Effects of Daeshihotang -sosonggitang-gagambang on liver injury or rats induced ccl4 and d-galactosamine. Korean J Orient Int Med 2000;21(2):267-74.
21 Kim Y, So HS, Kim SJ, Youn MJ, Lee JH, Kim NS, et al. Antiinflammatory effect of Daesiho, a Korean traditional prescription for cerebral infarct patients. Phytother Res 2008;22(6):829-35.   DOI
22 Choi HM, Kim SJ, Moon SO, LeeJ B, Lee HY, Kim JB. et al. Effects for the new formulation of Daesiho-tang on adipocyte development and differentiation in 3T3-L1. Kor J Herbol 2018;33(2):69-77.   DOI
23 Yeo UH, Jo HJ, Kim HH. Effects of DaeSiHo-Tang extract on hypertension and arterial contraction. Korean J Oriental Physiology & Pathology 2005;19(6):1573-9.
24 Park CS, Park CG, Han SD, Park SD. A Experimental Study on the Effect of Kami -Daesihotang on Hyperlipidemia & Hypertension J Int Korean Med 1998;19(2):159-84.
25 Song MY, Kim EK, Kong JC, Lee JH, Shin BC, Ryu DG, et al. Inhibitory effect of daesiho-tang extracts on high-fat diet-induced obesity. J Oriental Rehab Med 2008;18(3):41-9.
26 Hussain A, Yadav MK, Bose S, Wang JH, Lim D, Song YK, et al. Daesiho-Tang is an effective herbal formulation in attenuation of obesity in mice through alteration of gene expression and modulation of intestinal microbiota. PLoS One 2016;11(11):e0165483.   DOI
27 Kim CH, Kweon YM, Lee YT, Park SD. The preventive effect of Daeshiho-tang on liver damage induced by acetaminophen in the rats. Korean J Orien Med Prescription 2004;12(2):139-54.
28 한국지질동맥경화학회진료지침위원회. 이상지질혈증 치료지침. 제 4판. 서울: 도서출판 아카데미아; 2018, p. 5-28.