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http://dx.doi.org/10.22246/jikm.2019.40.3.312

Effect of Herbal Medicine on Hepatitis C: a Systematic Review and Meta-analysis  

Kang, Eun-jin (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-Eui University)
Kim, Kyong-lim (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-Eui University)
Kim, Kyoung-min (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-Eui University)
Publication Information
The Journal of Internal Korean Medicine / v.40, no.3, 2019 , pp. 312-330 More about this Journal
Abstract
Objectives: The present study aimed to provide clinical evidence on the effect of herbal medicine on the treatment of hepatitis C using a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: This study included RCTs that verified the effects of herbal medicine for the treatment of hepatitis C. A literature search of English, Chinese, and Korean databases was performed, and the selected literature was assessed to investigate the risk of bias. Results: The analysis included 14 RCTs. The total effective rate was the most commonly used outcome measure. The meta-analysis revealed that the total effective rate and total bilirubin difference were higher and that the recurrent rate was lower in the herbal medicine group than in the western medicine group (RR: 1.20, 95% CI: 1.06-1.35, p=0.003, I2=52; MD: 0.52, 95% CI: -0.62 to 1.66, p=0.37, I2=0; RR: 0.35, 95% CI: 0.11-1.09, p=0.07, I2=0). The included RCTs had relatively poor quality and a small sample size. Conclusion: Treatment with herbal medicine was found to be partially effective in treating hepatitis C. The included RCTs had relatively poor quality and a small sample size. This study can serve as a foundation for further clinical studies on the development of treatment methods for hepatitis C based on herbal medicine.
Keywords
hepatitis C; herbal medicine; randomized controlled trial; meta-analysis; systematic review;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Assosiation of Korean Medicine professors for Internal medicine of Liver system. Korean internal medicine of Liver system. Seoul: Nado publishing; 2016, p. 270-98.
2 Ning BQ, Mao DW, Zhang RZ, Wang TS. Observation of Chaishao Liujunzi Decoction on Treating Spleen Deficiency Syndrome of Chronic Hepatitis C Liver. Journal of Liaoning University of TCM 2017;19(7):84-6.
3 Zhao HJ. Observation on the effect of compound Xiaochaihu decoction in the treatment of chronic hepatitis C. Henan Medical Research 2017;26(20):3725-6.
4 Chen J, Li YC, Han XY, Miao YX, Liu ZM, Du ZH, et al. Clinical Study on Treatment of Hepatitis C with Bingganling. Hebei Journal of Traditional Chinese Medicine 1998;20(3):137-8.
5 Jiang YH. Treatment of 20 Cases of Hepatitis C with Yizhu Decoction. Journal of Nanjing University of Traditional Chinese Medicine 1999;15(4):256.
6 Xiao HQ, Luo RY, Wu YF, Deng TT. Clinical Observation on 32 Cases of Chronic Hepatitis B Treated by Jianpi Huoxue Formula. New Journal of Traditional Chinese Medicine 2005;38(11):33-5.   DOI
7 Li XX, Xiao HQ, Luo RY. Treatment of Chronic Hepatitis C by Jianpi Bushen Therapy: A Clinical Observation of 20 Cases. New Journal of Traditional Chinese Medicine 2006;38(11):33-5.   DOI
8 Dai XP, Gu WH. Treatment of 36 Cases of Chronic Hepatitis C with Liver Depression and Spleen Deficiency by Xiaochaihu Decoction. Zhejiang Journal of Traditional Chinese Medicine 2008;43(5):272.   DOI
9 Li DH, Li YG, Li DY. Clinical Study on Wuling Binggan Powder in Treating Hepatitis C. Information on Traditional Chinese Medicine 2011;28(1):70-1.   DOI
10 Batey RG, Bensoussan A, Yang YF, Bollipo S, Hossain MA. Preliminary Report of a Randomized, Double-blind Placebo-controlled Trial of a Chinese Herbal Medicine Preparation CH-100 in the Treatment of Chronic Hepatitis C. Journal of Gastroenterology and Hepatology 1998;13(1):244-7.   DOI
11 Mollison L, Totten L, Flexman J, Beaman M, Batey R. Randomized Double Blind Placebo-controlled Trial of a Chinese Herbal Therapy(CH-100) in Chronic Hepatitis C. Journal of Gastroenterology and Hepatology 2006;21(1):1184-8.   DOI
12 Seo SH, Oh SY, Lee JS, Cho WK, Kim TS, Ma JY. Effects of Soshiho-tang on Hydrogen Peroxide-induced Oxidative Damage in Hepatocytes. Korean J Orient Int Med 2011;32(4):487-96.
13 Batey R, Cao Q, Pang G, Clancy RL. Effects of CH-100, a chinese herbal medicine, on acute concanavalin A-mediated hepatitis in control and alcohol-fed rats. Alcohol Clin Exp Res 2000;24(6):852-8.   DOI
14 Lee SH, Jung JY, Park SM, Jegal KH, Byun SH, Cho IJ, et al. Hepatoprotective effect of Paeoniae radix via Nrf2 activation. Kor J Herbol 2016;31(1):33-40.   DOI
15 Jeong SH. Epidemiology of Hepatitis C Virus Infection in Korea. The Korean Journal of Medicine 2015;88(6):630-4.   DOI
16 Dan LL, Anthony SF, Dennis LK, Stephen LH, J Larry J, Joseph L. Harrison's principles of internal medicine. 18th edition. New york: McGraw-Hill medical; 2012, p. 2537-88.
17 Kim YS. Updated Treatment of Chronic Hepatitis C. The Korean Journal of Medicine 2017;92(1):24-35.   DOI
18 Kim BK, Jang ES, Kim JH, Park SY, Ahn SV, Kim JH, et al. Current status of and strategies for hepatitis C control in South Korea. Clinical and Molecular Hepatology 2017;23(3):212-8.   DOI
19 The Korean Association for the Study of the Liver(KASL). Guidelines for viral hepatitis C prevention and control 2017. Seoul: Jin publishing; 2017, p. 5-24.
20 Kim YS. Updated treatment of chronic hepatitis C. The Korean Journal of Medicine 2017;92(1):24-35.   DOI
21 Choi SH, Chang MW, Park SA, Lim SM, An JJ, Jo HK, et al. Two case report of Chunggan puls for Hepatitic C patient and Alcoholic Hepatitis patient with Cerebral-infarction. The Journal of Herbal Formula Science 2008;16(2):243-54.
22 Wang HM, Yang L, Cao CY, Sun YQ, Gao P, Wang ZG, et al. Effect of Yiqi Shenpi Method on Clinical Efficacy and TCM Syndromes of Chronic Hepatitis C. Clinical Journal of Traditional Chinese Medicine 2014;26(6):578-81.
23 Gu LP. Twenty-One Cases with Hepatitis C Treated Based on Syndrome Differentiation of Traditional Chinese Medicine. Henan Traditional Chinese Medicine 2015;35(11):2655-6.
24 Wang BY, Yuan XX, Zhang YL, Clinical Observation on Treatment of Chronic Hepatitis C with Gene Type I High Viral Load by Qishen Erlian Decoction. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases 2015;25(4):222-4.
25 Hou XL. Clinical Study on Self-made Yiqi Jiedu Huayu Decoction for Treatment of Refractory Hepatitis C. Chinese Journal of Information on TCM 2015;22(9):33-6.
26 Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, et al. NECA's guidance for undertaking systemic reviews and meta-analyses for intervention. Seoul: National Evedence-based Healthcare Collaboration Agency; 2011, p. 159-65.
27 Kim SH, Hong SH, Park DI. A case of adverse effects during Interferon plus ribavirin treatments for chronic hepatitis C. The Jouranl of Korean Acupuncture and Moxibustion Medicine Society 2003;20(1):244-53.
28 Kim SM, Lee JH, Woo HJ. The effect of injinchunggan -tang on Hepatitis C virus infection. J Korean Oriental Med 2001;22(1):53-62.