Browse > Article
http://dx.doi.org/10.22246/jikm.2017.38.6.1085

Case Series of Refractory Gastroesophageal Reflux Disease Treated with Lijin-tang-gamibang  

Ha, Na-yeon (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital)
Han, Ga-jin (Soram Korean Medicine Hospital)
Kim, Dae-jun (Dept. of Korean Internal Medicine, College of Korean Medicine, Daegu Haany University)
Ko, Seok-jae (Dept. of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University)
Park, Jae-woo (Dept. of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Jin-sung (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital)
Publication Information
The Journal of Internal Korean Medicine / v.38, no.6, 2017 , pp. 1085-1095 More about this Journal
Abstract
Objectives: The purpose of this study was to investigate the efficacy of Lijin-tang-gamibang on refractory gastroesophageal reflux disease (GERD). Methods: This before-and-after study compared the first medical examination and examination at the end of medical treatment. Twelve refractory GERD patients who visited the Department of Digestive Diseases of Kyung Hee University Korean Medicine Hospital from August 14th, 2017 to October 14th, 2017, were treated with Lijin-tang-gamibang for four consecutive weeks. The clinical characteristics of refractory GERD and the efficacy of herbal medical treatment was assessed by questionnaires, the Nepean Dyspepsia Index-Korean version (NDI-K), the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Numerical Rating Scale (NRS), the Korean version of the Perceived Stress Scale (KPSS-10), the Qi Stagnation Questionnaire (QSQ), the Spleen Qi Deficiency Questionnaire (SQDQ), and the Patient Global Impression of Change (PGIC). Prolonged effects were reported upon the follow-up telephone survey two weeks after treatment. Results: After treatment with the herbal medicine Lijin-tang-gamibang, the clinical characteristics of 12 refractory GERD patients were improved, especially in terms of the most common symptoms of acid regurgitation and heartburn. Each symptom score of NDI-K, KGSRS, NRS, SQDQ, and PGIC showed significant advances. Prolonged effects were reported in NDI-K, NRS and PGIC questionnaires two weeks after treatment. Conclusions: These results suggest that Lijin-tang-gamibang is an effective treatment for refractory GERD.
Keywords
refractory gastroesophageal reflux disease; GERD; Ligin-tang-gamibang; herbal medicine; case series;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Jung HK, Hong SJ, Jo YJ, Jeon SW, Cho YK, Lee KJ, et al. Updated guidelines 2012 for gastroesophageal reflux disease. Korean J Gastroenterol 2012;60(4):195-218.   DOI
2 Nam SJ, Park SC, Lee SJ. Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Korean J Med 2016;91(3):257-63.   DOI
3 Lee YC. Management of refractory GERD. Korean J Med 2010;78(3):301-8.
4 Heo J. Dongui Bogam. Seoul: Beobinmoonhwasa; 2002, p. 1126-66, 1210-4.
5 Kim HJ, Lim SY, Kwak MA, Kim DJ, Byun JS. Effects of Yijintang-gamibang on Reflux Esophagitis Induced by Pylorus and Forestomach Ligation In Rat. J Int Korean Med 2010;31(1):128-41.
6 Kim BS, Lim HY, Oh JH, Kim DW, Choi BH, Hur JI, et al. Seven Cases of Non-Erosive Gastroesophageal Reflux Disease Who were Treated by Lijintang-Gamibang and Acupuncture. J Int Korean Med 2005;26(4):926-34.
7 Kim N, Lee SW, Cho SI, Park CG, Yang CH, Kim HS, et al. The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Aliment Pharmacol Ther 2008; 27(2):173-85.   DOI
8 Kim JH, Kim BJ, Kim SW, Kim SE, Kim YS, Sung HY, et al. Current Issues on Gastroesophageal Reflux Disease. Korean J Gastroenterol 2014; 64(3):127-32.   DOI
9 Han GJ, Leem JT, Lee NL, Kim JS, Park JW, Lee JH. Development of a Standard Tool for Pattern Identification of Gastroesophageal Reflux Disease (GERD). J Int Korean Med 2015;36(2):122-53.   DOI
10 Lew GW, Jang IG, Park DW, Lew BH, Yoon SH. Clinical Study of Dansambohyultang on Tan-San and Jo-Jap. Kyung Hee Medical 1986; 2(4):89-95.
11 Kim DH, Kim HM, Lew JH, Um JY, Kim SH, Yang JH, et al. Korean Medicine Pharmacology. Seoul: Sinilsangsa; 2006, p. 49-53, 115-21, 243-6, 279-82, 561-2, 586, 613-9.
12 Park K, Kwak MA, Kim DJ, Byun JS. Protective Effects of Yijin-tang-gamibang Aqueous Extracts on Reflux Esophagitis Mediated by Antioxidant Defense Systems. Korean J Oriental Physiology & Pathology 2010;24(3):416-25.
13 Lee EH, Chung BY, Suh CH, Jung JY. Korean versions of the Perceived Stress Scale (PSS-14, 10 and 4): psychometric evaluation in patients with chronic disease. Scand J Caring Sci 2015; 29(1):183-92.   DOI
14 Talley NJ, Haque M, Wyeth JW, Stace NH, Tytgat GN, Stanghellini V, et al. Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index. Aliment Pharmacol Ther 1999; 13(2):225-35.   DOI
15 Cho YK, Choi MG, Kim SH, Lee IS, Kim SW, Chung IS, et al. The Effect of Mosapride on Quality of Life in Functional Dyspepsia. Korean J Gastroenterol 2004;43(3):160-7.
16 Svedlund J, Sjodin I, Dotevall G. GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1998;33(2):129-34.   DOI
17 Kwon SS, Jung HK, Hong JH, Park HS. Diagnostic Validity of the Korean Gastrointestinal Symptom Rating Scale(KGSRS) in the Assessment of Gastro-Esophageal Reflux Disease. Ewha Med J 2008;31(2):73-80.   DOI
18 Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24(4):385-96.   DOI
19 Terasawa K. A Western medicine practitioner's clinical oriental medicine. Seoul: Jibmoondang; 1998, p. 41-58.
20 Choi IY, Hang CH, Choi DJ, Jung SH, Shin GJ. A Comparision of Controlled and Uncontrolled Hypertension Groups Regarding Comprehensive Diagnosis of Qi Blood Water and Quality of Life. J Int Korean Med 2010;31(4):880-91.
21 Oh HW, Lee JW, Kim JS, Song EY, Shin SW, Han GJ, et al. Study on the Development of a Standard Instrument of Diagnosis and Assessment for Spleen Qi Deficiency Pattern. J Korean Med 2014;35(1):157-70.   DOI
22 Yang SY, Lee OY, Bak YT, Jun DW, Lee SP, Lee SH, et al. Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea: a population-based study. Dig Dis Sci 2008;53(1):188-93.   DOI