Browse > Article

Prevalence of HBsAg Positive and Abnormal Hepatic Enzyme among College Students by Health Examination in a Korean Medicine Hospital  

Ko, Heung (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University)
Kim, Ki-tae (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University)
Shin, Seon-mi (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University)
Publication Information
The Journal of Internal Korean Medicine / v.36, no.4, 2015 , pp. 470-477 More about this Journal
Abstract
Objectives: Given current vaccinations against the hepatitis B virus and changes in dietary lifestyles, the status of liver disorders, especially in the younger population, is different than it was in the past. This study aimed to discover the prevalence of the HBsAg positive and abnormal hepatic enzyme among college students.Methods: The study analyzed the medical examinations of 2,646 college students that were performed at Semyung University from March to September 2013.Results: A total of 11 out of 2,646 students (0.4%) showed as positive for the hepatitis B antigen, while 23.8% of students had the serum HBs antibody. A total of 212 students (8.0%) showed abnormally elevated serum levels of ALT, with significant differences between men and women. The prevalence of the abnormal serum ALT and its average value significantly increased according to an increase of BMI score, especially in male students.Conclusions: This study showed the importance of obesity as a causative factor in liver disorders, especially in the young generation. This finding will be useful for the development of therapeutics using Korean medicine in the future.
Keywords
liver; heptic disorder; hepatitis B virus ALT; obesity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Han MH, Kim SJ. Apolipoprotein E Polymorphism and Plasma Lipid Levels in Obese Children. Korean Journal of Pediatrics 2000;43:679-85.
2 Freedman DS, Burke GL, Harsha DW, Srinivasan SR, Cresanda JL, Weber LS, et al. Relationship of changes in obesity to serum lipid and lipoprotein in childhood and adolescence. JAMA 1985;254:515-20.   DOI
3 Kim MJ, Kim W, Hong YJ, Son BK, Pai SH, Chang KJ, et al. The Prevalence of Obesity and Underweight in Adolescents in Incheon Area and the Relationship between Serum Cholesterol Level and Obesity. Korean Journal of Pediatrics 2002;45(2):174-83.
4 Na JH, Cho HM, Chung KT, Choi SW, Park MJ, Sohn SJ. Sero-Prevalence of Hepatitis B Virus in University Students. J Agri Med & Community Health 2006;31(3):245-53.
5 Han CW, Kim SY, Min KS, Lee JH, Lee SH, Youn YS. Incidence of Liver Function Test Abnormality among Patients Hospitalized in an Oriental Hospital. J Korean Oriental Med 2010;31(2):109-13.
6 대한간학회. 비알코올 지방간질환 진료 가이드라인. 초판. 서울: 진기획; 2013, p. 1, 7, 8.
7 Ministry of Health & Welfare. National Health Statistics. 2013, p. 1.
8 송재철, 김길수. 체감의이인탕이 비만유도 흰쥐의 체중, 지방조직, 혈액변화, leptin과 Uncoupled protein에 비치는 영향. 대한한방비만학회지 2001;1(1):85-10.
9 문제혁, 이상준, 박정덕. 일개 철강 사업장에서 대사증후군의 위험요인과 γ-GTP와의 관련성. 대한산업의학회지 2007;19(1):17-25.
10 김상훈, 이지나, 홍윤철. 출퇴근 소요시간이 남자 근로자의 혈중 Gamma-glutamyltransferase에 미치는 영향. 대한산업의학회지 2002;14(4):418-25.
11 박승하, 김병익, 유태우, 김정욱, 조용균, 성인경, 등. 건강검진 수진자에서 비알코올성 지방간 및 간기능 장애: 인슐리 저항성과의 관계. 대한소화기학회지 2003;41(5):366-73.
12 손혜숙. 여성에서 경도 간기능 이상과 비만과의 관련성. 인제의학 2002;23(3):507-12.
13 장영석, 김승기, 서영성, 김대현, 신동학, 허정육. 비만 환자의 체중 감량과 유지에 영향을 주는 요인. 계명의대논문집 1998;17(1):100-10.
14 전국한의과대학 간계내과학 교수. 간계내과학. 4판. 서울: 나도출판사; 2015, p. 65-55, 265-3, 311, 325, 782.
15 김금룡. 서울 및 경기도 지역 주민에서의 B형 간염 항원에 대한 조사보고. 대한바이러스학회지 1981;11(1):35-40.
16 나지현, 조형민, 정권태, 최성우, 박민정, 손석준. 일부 대학생의 B형 간염 표면항원과 표면항체 양성률. 농촌의학, 지역보건학회지 2006;31(3):245-53.
17 최진섭, 성인화. 사람 혈청내 B형과 C형 간염 바이러스에 대한 항체분포. 대한바이러스학회지 1997;27(2):129-35.
18 장지연, 정수진, 김순기, 손병관, 홍영진, 홍광선. 인천 지역 초, 중, 고등학생의 B형 간염 바이러스 표면항원 양성률에 대한 조사연구. 소아감염 2003;10(2):153-8.
19 서경, 박숙경, 김영택, 박옥. 한국 임산부의 B형 간염 표면항원 양성률. 대한산부회지 2005;48(9):2119-24.
20 Petersen KM, Bulkow LR, McMahon BJ, Zanis C, Getty M, Peters H, et al. Duration of Hepatitis B Immunity in Low Risk Children Receiving Hepatitis B Vaccinations from Birth. The Pediatric Infectious Disease Journal 2004;23(7):650-5.   DOI
21 이귀녕, 이종순. 임상병리파일. 초판. 서울: 의학문화사: 1990, p. 228-9.
22 Braillon A, Capron JP, Herve MA, Degott C, Quenum C. Liver in obesity. Gut 1985;26:133-9.   DOI
23 Nasrallah SM, Wills CE Jr, Galambos JT. Hepatic morphology in obesity. Dig Dis Sci 1981;26:325-7.   DOI
24 Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver : a follow-up study. Journal of Hepatology 1995;22:1714-9.   DOI
25 Lee RG. Nonalcoholic steatohepatitis : a study of 49 patients. Hum Pathol 1989;20:594-8.   DOI
26 Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994;107:1103-9.
27 허준. 동의보감. 2판 서울: 남산당; 2004, p. 20.