Browse > Article

Case Study: Regression of a Residual Tumor and Prolongation of Overall Survival with Allergen-removed Rhus verniciflua Stokes after Chemoradiotherapy in Locally Advanced Non-small Cell Lung Cancer  

Kim, Kyung-suk (Dept. of Medical Consilience, Graduate School of Dan-Kook University)
Publication Information
The Journal of Internal Korean Medicine / v.36, no.2, 2015 , pp. 200-206 More about this Journal
Abstract
Objectives: The purpose of this study is to report the possibility of treatment of locally advanced non-small cell lung cancer with Traditional Korean Medicine based allergen-removed Rhus verniciflua Stokes (ARVS) following chemoradiotherapy. Methods: A patient with locally advanced non-small cell lung cancer (stage IIIB) felt chest discomfort, fatigue, and anxiety after chemoradiotherapy. To prevent recurrence, he opted to receive Traditional Korean Medicine. Results: After treatment with ARVS, the size of the residual primary cancer and a metastatic lymph node decreased, without new cancerous regions. The patient has maintained good performance and has shown prolonged overall survival. Conclusions: This report suggests that ARVS may play a therapeutic role in the treatment of locally advanced non-small cell lung cancer after chemoradiotherapy. Further studies will be needed to determine the effect of ARVS on locally-advanced unresectable non-small cell lung cancer.
Keywords
allergen-removed Rhus verniciflua Stokes; aRVS; locally advanced non-small cell lung cancer; chemoradiotherapy;
Citations & Related Records
연도 인용수 순위
  • Reference
1 정의민, 김혜미, 정종수, 이진수, 김경석, 윤성우. 감마나이프 시술 후 옻나무 추출물 투여로 전이성 뇌종양 소퇴 및 생존기간이 연장된 1례. 대한한의학회지 2009;30(5):157-62.
2 Lee SH, Kim KS, Choi WC, Yoon SW. Successful outcome of advanced pulmonary adenocarcinoma with malignant pleural effusion by the standardized rhus verniciflua stokes extract: a case study. Explore 2009 Jul-Aug;5(4):242-4.   DOI
3 이진수, 박형준, 채진, 김경석, 정현식, 이상헌, 등. 항암화확요법과의 순차적, 그리고 병행적 요법으로서의 aRVS 투여로 장기 생존과 좋은 삶의 질을 유지한 전이성 비소세포폐암 증례보고. 대한한방내과학회지 2011;32(1):129-35.
4 Cheon SH, Kim KS, Kim S, Jung HS, Choi WC, Eo WK. Efficacy and safety of Rhus verniciflua stokes extracts in patients with previously treated advanced non-small cell lung cancer. Forsch Komplementmed 2011;18(2):77-83.
5 Fournel P, Robinet G, Thomas P, Souquet PJ, Lena H, Vergnenegre A, et al. Randomized phase Ⅲ trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Français de Pneumo-Cancérologie NPC 95-01 Study. J Clin Oncol 2005 Sep 1;23(25):5910-7.   DOI
6 Choi W, Jung H, Kim K, Lee S, Yoon S, Park J, et al. Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center. J Biomed Biotechnol 2012:874276.
7 The World Health Organization(WHO). The World Health Report. 2003.
8 Perez CA, Pajak TF, Rubin P, Simpson JR, Mohiuddin M, Brady LW, et al. Long-term observations of the pattern of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy: report by the Radiation Therapy Oncology Group. Cancer 1987;59:1874-81.   DOI
9 Bejak A, Temin S, Franklin G, Giaccone G, Govindan R, Johnson ML, et al. Definitive and Adjuvant Radiotherapy in Locally Advanced Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline. J Clin Oncol 2015 JUN 20;33(18):2100-5.   DOI
10 Ahn SJ, Chung WK, Nah BS, Nam TK, Kim YC, Park KO. Outcomes after radiotherapy in inoperable patients with squamous cell lung cancer. J Korean Soc Ther Radiol Oncol 2001; 19:216-23.
11 배기채, 김성훈. 폐암의 변증과 치방에 관한 문헌적 고찰. 대전대학교 한의학연구소 논문집 1997: 243-64.
12 Eom SK, Kim KS. On estimation of indication, property and processing of Rhus Verniciflua Stokes. Journal of Korean Medical Classics 2008;21(2): 28-37.
13 통계청 국가통계포털 사망원인통계 2012.
14 Petrovich Z, Stanley K, Cox JD, Paig C. Radiotherapy in the management of locally advanced lung cancer of all cell types: final report of randomized trial. Cancer 1981;48:1335-40.   DOI
15 Furuse K, Fukuoka M, Kawahara M, Nishikawa H, Takada Y, Kudoh S, et al. Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with mytomycin, vindesine, and cisplatin in unresectable stage Ⅲ non-small-cell lung cancer. J clin Oncol 1999;17:2692-99.
16 Sause W, Kolesar P, Taylor S IV, Johnson D, Livingston R, Komaki R, et al. Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Easten Cooperative Oncology Group, and Southwest Oncology Group. Chest 2000;117:358-64.   DOI
17 전국한의과대학 본초학교실. 본초학. 서울: 영림사; 1991, p. 439.
18 Lee JD, Huh JE, Jeon G, Yang HR, Woo HS, Choi DY, et al. Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int Immunopharmacol 2009 Mar;9(3):268-76.   DOI
19 Lee J, Chae J, Lee S, Kim K, Eo W, Kim S, et al. The efficacy and safety of standardized allergen-removed Rhus verniciflua extract as maintenance therapy after first-line chemotherapy in patients with advanced non-small cell lung cancer. Am J Chin Med 2013;41(4):773-87.   DOI
20 Lee HK, Kwon HC, Lee SY, Kim JS. Treatment outcome of locally advanced non-small cell lung cancer. Radiation Oncology Journal 2006; 24(4):237-42.
21 Jang HS, Kook SH, Son YO, Kim JG, Jeon YM, Jang YS, et al. Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta 2005;1726(3):309-16.   DOI
22 Kim JH, Kim HP, Jung CH, Hong MH, Hong MC, Lee SD, et al. Inhibition of cell cycle progression via p27Kip1 upregulation and apoptosis induction by an ethanol extract of Rhus verniciflua stokes in AGS gastric cancer cells. Int J Mol Med 2006;18(1):201-8.