Browse > Article

The Effects of Jehasuogamibang on Antioxidation Activity and Dietary Hyperlipidemia-induced Mice  

Youn, Hyeon-Deok (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
Jo, Hyun-Kyung (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
Yoo, Ho-Ryong (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
Seol, In-Chan (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
Kim, Yoon-Sik (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
Publication Information
The Journal of Internal Korean Medicine / v.35, no.3, 2014 , pp. 244-261 More about this Journal
Abstract
Objectives: This experiments were performed to determine the effects of the Jehasuogamibang (製何首烏加味方: JHGB) on antioxidationactivity and hyperlipidemia induced by a hypercholesterolemic diet in mice. Methods: After treatment with JHGB expert safety in cytotoxicity and toxicity of Human fibroblast cells and liver and kidney, effect on Reactive Oxygen Species, serum total cholesterol, LDL-cholesterol, triglyceride, glucose, HDL-cholesterol, lipid peroxid of liver tissue, significantly increased SOD and catalase. Results: 1. JHGB showed safety in cytotoxicity and toxicity of human fibroblast cells and liver and kidney. 2. JHGB showed significant inhibitory effect on reactive oxygen species. 3. JHGB significantly decreased serum total cholesterol, LDL-cholesterol, triglyceride, and glucose, and significantly increased serum HDL-cholesterol. 4. JHGB significantly decreased lipid peroxide of liver tissue and significantly increased SOD and catalase. Conclusions: These results suggest that Jehasuogamibang is effective in antioxidationactivity and dietary hyperlipidemia-induced mice.
Keywords
Hyperlipidemia; Antioxidation Activity; Jehasuogamibang;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Jain KS, Kathiravan MK, Somani RS, Shishoo CJ. The biology and chemistry of hyperlipidemia. Bioorg Med Chem 2007;15(14):4674-99.   DOI   ScienceOn
2 http://kosis.kr/metadata/main.jsp?surv_id=19&curYear=2008, 통계청. 사망원인통계. 2008.
3 전국한의과대학 심계내과학교실. 한방순환신경내과학. 서울: 군자출판사; 2010, p. 184-9.
4 Mark H Beets. Robert Berkow. 머크 매뉴얼 17th. 서울: 한우리; 2003, p. 214-7.
5 신규성. Power internal medicine. 서울: 군자출판사; 2000, p. 300-17.
6 김광원, 서정돈, 이홍규, 박의현, 박정의, 박영배, 외. 고지혈증과 동맥경화. 서울: 의학; 2003, p. 3-8.
7 Walsh JM, Pignone M. Drug treatment of hyperlipidemia in women. JAMA 2004;291(18):2243-52.   DOI   ScienceOn
8 Farnier M, Davignon J. Current and future treatment of hyperlipidemia: the role of statins. Am J Cardiol 1998;82(4B):3J-10J.   DOI   ScienceOn
9 Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesteril concentration lower risk of ischemic heart disease?. BMJ 1994;308:367-72.   DOI   ScienceOn
10 Jeon KJ. Chung NS, Ahan SG, Ha JW, Lim SJ, Jang YS, Shim WH, Cho SY, Kim SS, Lee SH, Shin MJ. Studies on the efficacy and safety of Atovastatin in hypercholesterolemic (LDL-cholesterol) patients. Korean Circulation K 1999;29:1309-16.   DOI
11 Scandinavian Sinvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease. the Scandinavian Sinvastatin Survival Study(4S). Lancet 1994;344:1383-9.
12 楊維傑. 黃帝內徑靈樞譯釋. 서울: 일중사; 1991, p. 296, 397, 416, 611-2.
13 방혜정. 고지혈증에 대한 한의학적 고찰. 동서의학 1995;20:25-36.
14 Daniel J. Rader, Helen H. Hobbs. Harrison's Principles of Internal medicine. Section 3 Disorders of Intermediary Metabolism. 16th edition. Seoul: MIP; 2006, p. 2038-40, 2058, 2500-12.
15 黃春林. 心血管科專病中醫臨床診治 北京: 人民衛生出版社; 2007, p. 124.
16 박정의. 관상동맥경화증 위험인자의 역학연구. 한국지질학회지 제14차 추계학술대회 1997;101-8.
17 김치정. 고지혈증. 대한내과학회지 2002;62:44-57.
18 신현호. 고지혈증의 약물요법. 한국지질학회 제 1차 동맥경화와 고지혈증 Workshop 1994;41-9.
19 이귀녕. 임상병리파일. 서울: 의학문화사; 2000, p. 107-9, 124-9, 635-7, 919-22, 931-4.
20 서울대학교의과대학. 내분비학. 서울: 서울대학교출판사; 2005, p. 261.
21 Paaladinesh Thavendiranathan P, Bagai A, Brookhart AM, Choudhry MK. Primary prevention of cardiovascular diseases with statin theraphy. A meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:2307-13.   DOI   ScienceOn
22 Giugliano D. Dietry antioxidants for cardiovascular prevention. Nutr Metab Cardiovasc Dis 2000;10(1):38-44.
23 黃文東. 實用中醫內科學. 上海: 人民衛生出版社; 1986, p. 414-22.
24 趙永康. 高脂血證治法審析. 中醫雜誌 1988;29(7):66.
25 Halliwell B, Gutteridge JMC, Cross CE. Free radicals, actioxidants, and human disease : Where are we now? J Lab Clin Med 1992;119:598-620.
26 Enterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med 1991;11:81-128.   DOI   ScienceOn
27 Bedosa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen ${\alpha}1$ gene expression is associated with lipid peroxidation in hapatocellular injury : A link to tissue fibrosis? Hepatology 1994;19;1262-71.
28 이소연, 신유정, 박종혁, 김승모, 박치상. 경옥고의 성분 분석 및 추출물별 항산화효능비교. 대한본초학회지 2008;23(2):123-36.
29 Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF-${\alpha}$ and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995;96:2461-8.   DOI   ScienceOn
30 Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 1995;21:1304-9.
31 Stocker R, Frei B. Endogenous antioxidant defences in human blood plasma (in Oxidative Stress and Antioxidants). Orlando, FL: Academic Press Ltd; 1991, p. 213-42.
32 Deisseroth A, Dounce AL. Catalase physical and chemical properties, mechanism of catalysis, and physiological role. Physiological reviews 1970;50:319-75.
33 Araujo FB, Barbosa DS, Hsin CY, Maranhao RC, Abdalla DS. Evaluation of oxidative stress in patients with hyperlipidemia. Atherosclerosis 1995;117(1):61-71.   DOI   ScienceOn
34 Yang RL, Shi YH, Hao G, Li W, Le GW. Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index. J Clin Biochem Nutr 2008;43(3):154-8.   DOI   ScienceOn
35 Arca M, Natoli S, Micheletta F, Riggi S, Di Angelantonio E, Montali A, Antonini TM, Antonini R, Diczfalusy U, Iuliano L. Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. Free Radic Biol Med 2007;42(5):698-705.   DOI   ScienceOn
36 Racek J, Rusnakova H, Trefil L, Siala KK. The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia. Physiol Res 2005;54(1):87-95.
37 이경민, 서정철, 한상원. 황기약침액의 NO, DPPH 소거 및 IL-4 억제효과. 대한침구학회지 2003;20(2):184-94.
38 대한병리학회. 병리학. 서울: 고문사; 1994, p. 112-22, 125-9, 591-3, 1218-20.
39 전미혜. 오적산이 자궁근종세포의 사멸과 cell apoptosis에 미치는 영향. 대구한의대학교대학원 2003.
40 강호영, 권병석, 김강주, 김덕룡, 김영호, 박주홍, 외. KUBY 면역학. 서울: 월드사이언스; 2006, p. 31.
41 Martin MJ. Serum cholesterol, blood pressure, and mortality : implicaions from a cohort of 361662 men. Lancet 1986;2:933-9.