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Experimental Study on the Antidepressant Effects of Magnolia Officinalis Extracts  

You, Ju-Yeon (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University)
Woo, Chan (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University)
Jeong, Hye-Ryon (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University)
Choi, Jung-Hoon (Hamsoa Oriental Medical Clinic)
Lee, Un-Jung (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University)
Publication Information
The Journal of Internal Korean Medicine / v.34, no.3, 2013 , pp. 256-266 More about this Journal
Abstract
Objectives : The purpose of this study was to investigate the protective effects of Magnolia Officinalis extracts on the animal model of depression induced by immobilization stress. Methods : The subjects were divided into 4 groups : normal, saline solution-administered during immobilization stress, 200 mg/kg of magnolia extracts-administered (magnolia extract 200), and 400 mg/kg of magnolia extracts- administered (magnolia extract 400). During 2 days of immobilization stress treatment, they underwent forced swimming test (FST) and tail suspension test (TST). The number of serotonin (5-HT) immunostained nuclei in the dorsal raphe nucleus regions was measured by immunohistochemistry. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) in blood were measured. Results : In FST, magnolia-administered groups showed significantly decreased immobilization. In TST, the magnolia extract 400 group showed decreased immobilization. The stress group showed significantly decreased number of 5-HT immunostained nuclei in the dorsal raphe nucleus regions, while magnolia extract 400 group showed increased number of 5-HT immunostained nuclei. Stress group showed decrease in serum level of SOD and GPX, while the magnolia extract 200 group showed increase in serum level of SOD and GPX. Conclusions : These results suggest potent effectiveness of magnolia extracts in the treatment of depression.
Keywords
antidepressant; Magnolia Officinalis; forced swimming test; tail suspension test;
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Times Cited By KSCI : 4  (Citation Analysis)
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