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Effect of Jichul-hwan Extract on Gastric Contractility in Conscious Rats  

Kang, Kyung (Dept. of Gastroenterology, College of Korean Medicine, Kyung-Hee University)
Yoon, Sang-Hyub (Dept. of Gastroenterology, College of Korean Medicine, Kyung-Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.34, no.2, 2013 , pp. 147-154 More about this Journal
Abstract
Objectives : The aims of this study was to find out whether Jichul-hwan (JCH) extract has an effect on gastric contractility in conscious rats by using a force transducer implanted in the body of the stomach. Methods : The force transducer (model: F-081S, Starmedical, JAPAN) was implanted to the exterior wall of the stomach body in rats. The gastric contractility was measured 30 minutes before and after administration of JCH (110.1 mg/kg). The control group was administrated with normal saline instead of JCH to compare the effect of JCH. The gastric contractility of the control group (normal saline: NS) was also measured 30 minutes before and after administration of NS. Results : The ratio of gastric contractility between before and after medication by JCH was $1.707{\pm}0.731$, and with NS was $0.701{\pm}0.541$. The gastric motility increased by JCH was significantly higher than NS. Conclusions : JCH extract increases gastric contractility in conscious rats. We could expect that this drug would be effective in the treatment of functional dyspepsia or post-surgical gastroparesis.
Keywords
Jichul-hwan; force transducer; conscious rats; gastric contractility;
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