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Effect of partial pyloric obstruction on body weight, gastric juice, gastric surface area and gastric edema in normal intact rats and/or vagotomized rats  

Seon, Jong-Ki (Dept. of Gastroenterology, School of Oriental Medicine, Kyung-Hee University)
Yoon, Sang-Hyub (Dept. of Gastroenterology, School of Oriental Medicine, Kyung-Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.33, no.1, 2012 , pp. 26-38 More about this Journal
Abstract
Objectives : The aim of this study was to investigate the effect of partial pyloric obstruction on body weight, gastric juice, gastric surface area and gastric edema in normal intact and/or vagotomized rats. Methods : Partial pyloric obstruction was performed by wrapping a non-absorbable rubber ring (D:6 mm, W:4 mm, T:1 mm) around the 1st portion of the duodenum. Vagotomy was performed by resecting the branches around the esophagogastric junction. Pre-post body weight differential, fasting gastric juice volume, gastric surface area and gastric edema were measured at 8 weeks and 20 weeks. For the effect of pyloric reperfusion the rubber ring was removed after 8 weeks and then an additional 12 weeks of observation was performed to the end of the 20-week experimental period. Results : In the initial 8 weeks observation, the effect of pylorus obstruction and/or vagotomy was significantly remarkable in the pylorus obstructed and vagotomized group; slowdown of weight gain, increase of fasting gastric juice volume, dilatation of gastric surface area and severe gastric edema were shown. In the remaining 12 weeks observation, the effect of reperfusion was significantly remarkable in the ring-removed antral dilated group; recovery of weight gain, decrease of gastric surface area and decrease of gastric edema were shown. However, gastric juice volume was not significantly different from the other group. Conclusions : Partial pyloric obstruction plays a aggravating role and the vagus nerve plays a protective role in body weight, gastric juice, gastric surface area, and gastric edema. Furthermore, pyloric valve dysfunction as an aggravating factor strengthened in defect of the vagus nerve. These results suggest that patients with both functional pyloric outlet obstruction and hypofunction of vagus nerve need to be diagnosed in good time and treated properly.
Keywords
partial pyloric obstruction; vagotomy; body weight; gastric surface area; gastric juice; gastric edema;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Hausken T, Berstad A. Wide gastric antrum in patients with non-ulcer dyspepsia. Effect of cisapride. Scand J Gastroenterol 1992;27:427-32.   DOI
2 King PM, Pryde A, Heading RC. Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux. Gut 1987;28:545-8.   DOI
3 Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945;5:43.
4 김진석, 윤상협. 내소산의 정상 및 위유문부 혹장 흰쥐의 위 운동성에 대한 효능. 대한한방내과학회지 2008;29(1):117-29.
5 박상종, 이풍렬, 김지은, 김영호, 손희정, 김재준, 등. 기능성 소화불량증에서 위하수의 임상적 의의. 대한내과학회지 1999;57(3):298-303.
6 Malbert CH, Mathis C, Laplace JP. Vagal control of transpyloric flow and pyloric resistance. Dig Dis Sci 1994;39(12):24-7.   DOI
7 Gu C, Ke M, Wang Z. Temporal and spatial relationship of pylorus to antroduodenal motility in functional dyspepsia. Chin Med J 1998;111(10):906-9.
8 Tack J, Jones MP, Karamanolis G, Coulie B, Dubois D. Symptom pattern pathophysiological correlates of weight loss tertiary-referred functional dyspepsia. Neurogastroenterol Motil 2010;22(1):29-35, e4-5.
9 van der Burg JM, Winqvist A, Aziz NA, Maat-Schieman ML, Roos RA, Bates GP, et al. Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice. Neurobiol Dis 2011;44:1-8.   DOI
10 許浚. 東醫寶鑑. 서울: 동의보감출판사; 2005, p. 198-202.
11 Parise P, Rosati R, Locatelli A, Ceolin M, Tatum RP, Braghetto I. Barett's esophagus: surgical treatments. Ann NY Acad Sci 2011;1232:175-95.   DOI
12 Hiroto M, Jiro W, Hirokazu F, Tadayuki O, Toshihiko T, Jun S, et al. Current understanding of pathogenesis of functional dyspepsia. J gastroenterol hepatol 26. 2011;3:57-60.
13 이수연, 최창환, 이현웅, 도미영, 이승현, 한상표, 등. 건강 검진자에서 기능성 소화불량증 아형에 따른 빈도 및 연관인자. 대한소화관운동학회지 2007;13(1):31-7.
14 홍인아, 윤상협. 기능성 소화불량증 환자의 위장관 부교감 신경, 위유문부의 기능 및 임상양상에 대한 조사(한방병원 내원 환자를 중심으로). 대한한방내과학회지 2008;29(3):666-74.
15 Bortolotti M, Bolondi L, Santi V, Sarti P, Brunelli F, Barbara L. Patterns of gastric emptying in dysmotility-like dyspepsia. Scand J.Gastroenterol 1995;30:408-10.
16 정용재, 윤상협. 비폐색성 위 전정부 확장이 있는 흰쥐의 위 수축력, 체중 및 위 형태 복원에 대한 苓桂朮甘湯과 補中益氣湯의 효능. 대한한방내과학회 2010;31(4):857-69.
17 Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labo G. Measurement of gastric emptying time by real-time ultrasonography. Gastroenterology 1985;89:752-9.   DOI
18 Pallotta N, Pezzotti P, Corazziari E. Relationship between antral distension and postprandial symptoms in functional dyspepsia. World J Gastroenterol 2006;12(43):6982-91.   DOI
19 Riezzo G, Chiloiro M, Guerra V, Borrelli O, Salvia G, Cucchiara S. Comparison of gastric electrical activity and gastric emptying in healthy and dispeptic children. Dig Dis Sci 2000;45(3):517-24.   DOI
20 Loreno M, Bucceri AM, Catalano F, Muratore LA, Blasi A, Brogna A. Pattern of gastric emptying in functional dyspepsia. An ultrasonographic study. Dig Dis Sci 2004;49:404-7.   DOI
21 Avenhaus W, Kemper B, von Bally G, Donschke W. Gastric wall elasticity assed by dynamic endoscopy: ex vivo investigations in the porcine stomach. Gastrointest Endosc 2001;54(4):496-500.   DOI
22 Egorov V, Schastlivtev I, Prut E, Baranov A, Turusov R. Mechanical properties of the human gastrointenstinal tract. J Biomech 2002;35(10):1417-25.   DOI
23 Ricci R, Bontempo I, La Bella A, De Tschudy A, Corazziari E. Dyspeptic symptoms and gastric antrum distribution. An ultrasonographic study. Ital J Gastroenterol 1987;19:215-7.
24 James AN, Ryan JP, Crowell MD, Parkman HP. Regional gastric contractility alterations in a gastroparesis mouse model: effects of cholinergic and serotonergic stimulation. Am J physiol gastrointest Liver Physiol 2004;287:G612-9.   DOI
25 Andrews PLR, Bingham S. Adaptation of the mechanisms controlling gastric motility following chronic vagotomy in the ferret. Exp physiol 1990;75:811-25.   DOI
26 Kallmunzer B, Schwab S, Kollmar R. Mild hypothermia of 34degreesC reduces side effects of rt-PA treatment after thromboembolic stroke in rats. Exp Transl Stroke Med 2012;4(1):3.Epub ahead of print.   DOI