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Influence of Herbal Medicines which include Ginseng Co-administration on the PT INR in Patients Taking Warfarin : 10 Case Series  

Kwon, Seung-Won (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Park, Joo-Young (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Byeon, Hyung-Sik (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Yoon, Seung-Kyu (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Seo, Yu-Ri (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Jung, Woo-Sang (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Moon, Sang-Kwan (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Cho, Ki-Ho (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Kim, Young-Suk (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.31, no.3, 2010 , pp. 675-687 More about this Journal
Abstract
Objective : Interaction of warfarin with herbal medicines still remains controversial. The aim of this study was to examine the effect of herbal medicines which contain ginseng on PT INR in patients being treated with warfarin. Method : We studied patients who take herbal medicines which contain ginseng with warfarin during their hospitalization. We retrospectively investigated the effect of herbal medicines which contain ginseng. 10 patients were assigned to receive one of the following adjuncts: Group A (n=4) that received Bojungikkitang-gagam, Group B (n=2) that received Ukgunjatang-gagam, and Group C (n=4) that received Shihogyeji-tang, Gamiondam-tang, Gwininaanshim-tang, and Saengpe-san together. We then investigated changes of PT INR in each group. Result : In group A, there were diminutions of PT INR in 3 cases, and increment in 1 case. In group B, there were increments of PT INR in both cases. In group C, there were increments of PT INR in 3 cases and there was no big change in 1 case. Conclusion : In this study, we found that the interaction of combined herbal medicine is very complicated. So, we must study further more study about interactions of combined herbal medicine on PT INR.
Keywords
Ginseng Radix; Warfarin; Combined therapy; Prothrombin Time; Herbal medicine;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Kim EJ, Lee SH, Kim LD, Yun SP, Rhee JW, et al. Influence of Herbal Medicine Coadministration on the INR in Stroke Patients Taking Warfarin. J Korean Oriental Med. 2004;25(2):165-72.   과학기술학회마을
2 吳謙等編. 標點․索引御纂․醫宗金鑑. 法仁文化社; 2006, p. 403, 597, 605, 617, 1154, 1155.
3 Yuan CS, Gang W, Dey L, Karrison T, Nahlik L, et al. Brief communication: American Ginseng Reduces Warfarin's Effect in Healthy Patients. A randomized controlled trial. Ann Intern Med. 2004;141:23-7.   DOI   ScienceOn
4 Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health-Syst Pharm. 1997;54:692-3.
5 Cheng TO. Interaction of herbal medicine with coumadin. J Emerg Med. 2000;18:122.
6 Rosada MF. Thrombosis of a prosthetic aortic valve disclosing a hazardous interaction between warfarin and a commercial ginseng product. Cardiology. 2003;99:111.   DOI   ScienceOn
7 Cheng TO. Warfarin danshen interaction. Ann Thorac Surg. 1999;67:894.   DOI
8 Cheng TO. Herbal remedies. Am Fam Phys 1999;60:1661.
9 Yu CM, Chan JCN, Sanderson JE. Chinese herbs and warfarin potentiation by 'Danshen'. J Intern Med. 1997;241:337-9.   DOI   ScienceOn
10 Ellis GR, Stephens MR. Minerva. BMJ. 1999; 319:652.   DOI   ScienceOn