Browse > Article

Effect of Sunhwangigagambang(SHG) on Hyperlipidemia in SD Rats Induced by High Cholesterol Diet  

Kim, Dong-Hyun (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Lim, Seung-Min (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Ahn, Jung-Jo (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Jo, Hyun-Kyung (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Yoo, Ho-Ryong (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Kim, Yoon-Sik (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Seol, In-Chan (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
Publication Information
The Journal of Internal Korean Medicine / v.31, no.3, 2010 , pp. 526-538 More about this Journal
Abstract
Objective : This study was performed to investigate the effect of Sunhwangigagambang(SHG) on hyperlipidemia in SD rats induced by high cholesterol diet. Method : After treatment with SHG, cytotoxicity, body weight, liver weight, AST, ALT, ALP, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, albumin, total protein in serum, malondialdehyde, and gene expression for ACAT and HMG-CoA reductase in hepatic tissue were analyzed. Result : 1. SHG didn't show any cytotoxicity in both human fibroblast cell line and SD rats. 2. SHG significantly inhibited the increase of liver weight by high cholesterol diet compared to the control group. 3. SHG significantly ameliorated the increase of total cholesterol, LDL-cholesterol, and triglyceride and reduction of HDL-cholesterol compared to the control group. 4. SHG significantly reduced glucose level in serum compared to the control group. 5. SHG significantly reduced malondialdehyde in hepatic tissue compared to the control group. 6. SHG significantly down-regulated gene expression of ACAT and HMG-CoA reductase compared to the control group. Conclusion : These results suggest that SHG might be effective in treatment and prevention of hyperlipidemia.
Keywords
Sunhwangigagambang(SHG); Hyperlipidemia; HMG-CoA reductase; Cholesterol;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 裵晟漢, 南昌圭. 四物湯및 構成藥物이 家兎의 收縮血管에 미치는 影響. 대한한방내과학회지. 2000;21(1):23-30.
2 Hunt JV, Smith CCT Wolff SP. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes. 1990;39:1420-4.   DOI   ScienceOn
3 Austin MA, Rodriguez BL, McKnight B, McNeely MJ, Edwards KL, Curb JD et al. Low-density lipoprotein particle size, triglycerides, and highdensity lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men. The American Journal of Cardiology. 2000; 86(4):412-6.   DOI   ScienceOn
4 Spector AA, Fletcher JE, Ashbrook JD. Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants. Biochemistry. 1971;10(17): 3229-32.   DOI   ScienceOn
5 Ryu SY, Lee YS, Park J, Kang MG, Kim KS. Relations of plasma highsensitivity C-reactive protein to various cardiovascular risk factors. J Korean Med Sci. 2005;20(3):379-83.   DOI   ScienceOn
6 Gills PJ, Robinson C, Rathgeb KA. Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis implications for drug discovery. Atherosclerosis. 1990;83:177-85.   DOI
7 박원환. 白鼠의 高脂血症病態誘發에 관한 實驗的硏究. 동의병리학회지. 1995;10:21-43.
8 Grundy SM, Cleeman JI, Merz NB, Brewer BB Jr, Clark LT, Hunninghake DB. NCEP report; Implications of recent clinical trials for the NCEP Adult Treatment Panel III guidelines. Circulation. 2004;110:227-39.   DOI   ScienceOn
9 章眞如. 風火痰瘀論. 北京: 人民衛生; 1986, p.5-7.
10 전국한의과대학병리학교실. 한방병리학. 서울:一中社; 2004, p. 81-95.
11 김창민, 신민교, 안덕균, 이경순 외. 중약대사전. 서울: 정담; 1997, p. 887-95, 1678-85, 5164-70.
12 김종중, 문정석, 정주현, 문영희. 고지방 식이 및 참당귀의 엑기스 투여가 흰쥐 관상동맥벽의 탄력섬유에 미치는 형태학적 연구. 朝鮮醫大論文集. 1983;8(1):139-52.
13 全國韓醫科大學本草學敎授. 本草學. 서울: 영림사;2000, p. 302-4, 409-10, 423-5, 427-8, 448-51, 467-8, 536-7, 580-3.
14 Metz SA. Altered arachidonic acid synthesis and lipid peroxidation in diabetes mellitus; possible roles in leukocyte dysfunction and other cellular defects. Med Hypotheses. 1983;12(4):341-57.   DOI   ScienceOn
15 김장락, 홍대용, 박성학. 뇌혈관질환의 위험요인에 대한 환자-대조군 연구. 예방의학회지. 1995;28(2):473-86.
16 D'Agostino RB, Russell MW, Huse DM, Ellison RC, Silbershatz H, Wilson PWF et al. Primary and subsequent coronary risk appraisal; New results from the Framingham study. American Heart Journal. 2000;139:272-81.   DOI
17 대한내과학회. 해리슨 내과학. 제17판. 서울: 도서출판 MIP; 2006, p. 1559-64.
18 方惠貞, 貞宜洙, 洪律喜, 姜允皓. 高脂血症에 對한 韓醫學的考察. 東西醫學. 1995;20(1):25-36.
19 차관배, 안정조, 조현경, 유호룡, 김윤식, 설인찬. 降脂通脈飮이 항산화 활성과 高脂血誘發白鼠에 미치는 影響. 대한한방내과학회지. 2008;29(3):703-15.   과학기술학회마을
20 이재휘, 임승민, 안정조, 조현경, 김윤식, 설인찬 등. 雙降湯이 高cholesterol 食餌로 誘發된 高脂血症白鼠에 미치는 影響. 대한한방내과학회지.2008;29(2):432-42.   과학기술학회마을
21 정명헌, 임종훈, 오형수. 한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 실험적 고지혈증에 미치는 영향. 생약학회지. 1998;29(4):300-11.
22 박소애, 조현경, 유호룡, 김윤식, 설인찬, 안정조. 加味地黃湯이 高脂血症關聯因子에 미치는 영향. 대한한방내과학회지. 2009;30(2):338-54.   과학기술학회마을
23 신흥묵. 豨簽의 혈관이완 효능과 항산화 동태에 관한 연구. 대한한의학회지. 2000;21(1):77-83.
24 노환성, 고우경, 양현옥. 박건구, 조영환, 박형섭. 고지혈증 랫트를 이용한 작약의 수종 용매 추출물에 의한 항고지혈 효과. 약제학회지. 1997;27(2):145-51.
25 신규성. Power 내과. 제8판. 서울: 군자; 2009, p.410-29.
26 김상현. 이상지질혈증의 최신 진료 지침. 2006 지질동맥경화아카데미. 2006:250-64.
27 Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels; The Framingham Study. JAMA. 1986; 256(20):2835-8.   DOI   ScienceOn
28 Jacobs DR, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA. High density lipoprotein cholesterol as a predictor of cardiovascualr disease mortality in men and women; The follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1990;131(1):32-47.   DOI
29 한기훈. 중성지방은 죽상경화를 일으키는가?. 대한내분비학회지. 2009;24(3):151-5.   DOI   ScienceOn
30 Thavendiranathan P, Bagai A, Brookhart MA, Choudhry NK. Primary prevention of cardiovascular diseases with statin theraphy; A meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166:2307-13.   DOI   ScienceOn