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http://dx.doi.org/10.5658/WOOD.2018.46.6.692

Plant Extracts Inhibiting Biofilm Formation by Streptococcus mutans without Antibiotic Activity  

Ham, Youngseok (Department of Forest Products and Biotechnology, Kookmin University)
Kim, Tae-Jong (Department of Forest Products and Biotechnology, Kookmin University)
Publication Information
Journal of the Korean Wood Science and Technology / v.46, no.6, 2018 , pp. 692-702 More about this Journal
Abstract
Streptococcus mutans causes oral diseases, including tooth decay, by producing a biofilm called plaque. Therefore, inhibition of biofilm formation is essential for maintaining oral health. Plants produce a variety of secondary metabolites, which act as starting sources for the discovery of new bioactive chemicals that inhibit biofilm formation of S. mutans. Previous studies have reported on chemicals with antibiotic activity for the inhibition of biofilm formation by S. mutans. In this study, nine plant extracts from Melonis Pedicellus, Agastachis Herba, Mori Cortex Radicis, Diospyros kaki leaves, Agrimoniae Herba, Polygoni Multiflori Radix, Lycopi Herba, Elsholtziae Herba, and Schizonepetae Spica were screened for the inhibition of biofilm formation from a plant extract library. The water-soluble compounds of the extracts did not affect cell growth but selectively inhibited biofilm formation. These results suggest that the selected plant extracts constitute novel biofilm formation inhibitors, with a novel biological mechanism, for improving oral hygiene.
Keywords
biofilm; plaque; Streptococcus mutans; plant extract; Mori Cortex Radicis;
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