Browse > Article
http://dx.doi.org/10.5658/WOOD.2017.45.3.317

Evaluation of Biological Activity on Hawthorn Tree (Crataegus pinnatifida) Extracts  

Min, Hee-Jeong (Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University)
Kim, Young-Kyoon (Department of Forest Products & Biotechnology, Kookmin University)
Bae, Young-Soo (Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.45, no.3, 2017 , pp. 317-326 More about this Journal
Abstract
The wood and bark of Hawthorn tree (Crataegus pinnatifida Bunge) were immersed with 70% aqueous acetone for 3 days. After filtering, the wood extracts were fractionated with n-hexane, chloroform ($CHCl_3$), n-butanol (n-BuOH) and $H_2O$, and the bark extracts were fractionated with n-hexane, $CHCl_3$, ethylacetate (EtOAc) and $H_2O$. Then antioxidative and anti-inflammatory activities were evaluated on each fraction. Antioxidative activity indicated high activity in the n-butanol soluble fraction of wood and in the EtOAc soluble fraction of bark. Especially, the EtOAc soluble fraction of bark showed much higher antioxidative value compared to the controls, buthylated hydroxytoluene (BHT) and ${\alpha}$-tocopherol. In the anti-inflammatory activity, all of the tested fractions except the $H_2O$ soluble fraction of wood showed high inhibitory effect on nitric oxide (NO) production. Based on the above results, the extracts of hawthorn tree may be applied for one of the natural biomass sources that can be used as an antioxidant and an anti-inflammatory substance.
Keywords
Hawthorn tree (Crataegus pinnatifida Bunge); wood; bark; biological activity; antioxidative activity; anti-inflammatory activity;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Aviram, M. 2000. Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radical Research 33(suppl.): 85-97.
2 Bickers, D.R., Athar, M. 2006. Oxidative stress in the pathogenesis of skin disease. Journal of Investigative Dermatolohy 126: 2565-2575.   DOI
3 Blois, M.S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200.   DOI
4 Duan, Y., Kim, M.A., Seong, J.H., Lee, Y.G., Kim, D.S., Chung, H.S., Kim, H.S. 2014. Impacts of various solvent extracts from Wild Haw (Crataegus pinnatifida Bunge) pulpy on the antioxidative activites. Journal of the East Asian Society of Dietary Life 24(3): 392-399.
5 Hong, S.S., Hwang, J.S., Lee, S.A., Han, X.H., Hwang, J.S., Lee, K.S. 2002. Inhibitors of monoamine oxidase activity from the fruits of Crataegus pinnatifida Bunge. Korean Journal of Pharmacognosy 33(4): 285-290.
6 Jurikova, T., Sochor, J., Rop, O., Mlcek, J., Balla, S., Szekeres, L., Adam, V., Kizek, R. 2012. Polyphenolic profile and biological activity of chinese hawthorn(Crataegus pinnatifida Bunge) fruits. Molecules 17: 14490-14509.   DOI
7 Kim, H.S., Duan, Y., Kim, M.A., Jang, S.H. 2014. Contents of antioxidative components from pulpy and seed in Wild Haw (Crataegus pinnatifida Bunge). Journal of Environmental Science International 23(11): 1791-1799.   DOI
8 Kang, I.H., Cha, J.H., Lee, S.W., Kim, H.J., Kwon, S.H., Ham, I.H., Hwang, B.S., Whang, W.K. 2005. Isolation of anti-oxidant from domestic Crataegus pinnatifida Bunge leaves. Korean Journal of Pharmacognosy 36(2): 121-128.
9 Kao, E.S., Wang, C.J., Lin, W.L., Yin, Y.F., Wang, C.P., Tseng, T.H. 2005. Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo. Journal of Agricultural Food Chemistry 53(2): 430-436.   DOI
10 Kim, H.K., Kim, Y.E., Do, J.R., Lee, Y.C. and Lee, B.Y. 1995. Antioxidatives activity and physiological activity of some Korean Medicinal Plants, Korean Journal of Food Science and Technology 27(1): 213-217.
11 Kim, Y., Lee, Y.S., Hahn, J.H., Choe, J., Kwon, H.J., Ro, J.Y., Jeoung, D. 2008. Hyaluronic acid targets CD44 and inhibits FcepsilonRI signaling involving PKCdelta, Rac1, ROS, and MAPK to exert anti-allergic effect. Molecular Immunology 45(9): 2537-2547.   DOI
12 Lim, D.K., Choi, U., Shin, D.H. 1996. Antioxidant activity of ethanol from Korean Medicinal Plants. Korean Journal of Food Science and Technology 28(1): 83-89.
13 Novo, E., Parola, M. 2008. Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair 1: 1-58.   DOI
14 Park, S.J., Shin, E.H., Lee, J.H. 2012. Biological activities of solvent fractions from methanolic extract of Crataegi fructus. The Korean Journal of Food and Nutrition 25(4): 897-902.   DOI
15 Wei, W., Li, X.Y., Zhang, H.Q., Wu, S.G. 2004. Antiinflammatory and immunopharmacolohy. 1st ed. Beijing : Renminweishengchubanshe: 10-17.
16 Williams, G.M., Iatropoulos, M.J., Whysner, J. 1999. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. Food and chemical Toxicology 37: 1027-1038.   DOI